Analysis of polybrominated diphenyl ethers, hexabromocyclododecanes, and legacy and emerging phosphorus flame retardants in human hair

Tang, Bin; Zheng, Jing; Wang, Mei-Huan; Cai, Fengshan; Luo, Weikeng; Xu, Rong; Yu, Yunjiang

doi:10.1016/j.chemosphere.2020.127807

Cited by 21 publications

(5 citation statements)

References 39 publications

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“…The high DF of contaminants in hair demonstrated that both legacy and emerging contaminants are widely encountered in the environment. Median concentrations of ∑ 11 PFRs (196 ng/ g) in this study were significantly lower than in Qingyuan ewaste workers (816 ng/g) 17 and in the general population in the United States (1530 ng/g), Belgium (1712 ng/g), and paired mothers and children in Norway (310 ng/g). 24−26 Similarly, a higher proportion of PFAS relative to other contaminants indicates that PFAS, and particularly PFHxS and PFHxDA, are widespread chemicals.…”

Section: ■ Discussioncontrasting

confidence: 67%

“…Detection of PFRs, PFAS, and BPs. Human hair samples were prepared as described previously, 17 and additional details can be found in Text S2 and Table S3. PFRs, PFAS, and BPs were separated on a Kinetex Biphenyl 100A column and a Poroshell 120 EC-C18 column and analyzed using an AB SCIEX API 6500 Triple Quadrupole LC-MS/MS system with an Agilent 1260 series liquid chromatography system.…”

Section: ■ Methods and Materialsmentioning

confidence: 99%

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Quantitative Associations of Polluting Chemicals and Endogenous Biomolecules in Hair: An Observational Perspective from a Population-Based Study

Huang,

Liao,

Yang

et al. 2024

Environ. Sci. Technol. Lett.

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Hair is a valuable, non-invasive material for human biomonitoring. However, little is known about polluting contaminants in hair, particularly regarding the relationship between biocomponents and contaminant levels in hair. We measured the concentrations of 42 contaminants, including 11 phosphorus flame retardants (PFRs), 13 bisphenols (BPs), and 18 perfluoroalkyl and polyfluoroalkyl substances (PFAS), while simultaneously measuring the levels of keratin, melanin, and eight sphingolipids in hair samples. Long-chain sphingolipids (C20CER) were negatively associated with levels of PFRs, PFAS, and BPs, while C12CER and C14CER (short-chain) were positively associated with levels of PFRs and BPs. Furthermore, we observed an overall negative association between ∑7PFRs and endogenous biocomponents but a positive dose–effect relationship with ∑5BPs and biocomponents using Bayesian kernel machine regression models. Among the biocomponents, C20CER and C14CER contributed the most to the negative and positive associations, respectively. Specifically, a change in Ln C20CER (Z-score) concentration from the 25th to 75th percentile was associated with a decrease in ∑7PFRs of 47.0%-SD (−61.8%, −32.3%) when other biocomponents were at their median values. These findings provide new insights into the relationships between biocomponents and contaminants in hair, which is an essential step for the advancement of hair as a biomonitoring material.

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Section: ■ Discussioncontrasting

confidence: 67%

Section: ■ Methods and Materialsmentioning

confidence: 99%

Quantitative Associations of Polluting Chemicals and Endogenous Biomolecules in Hair: An Observational Perspective from a Population-Based Study

Huang,

Liao,

Yang

et al. 2024

Environ. Sci. Technol. Lett.

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“…According to several studies, deactivated orisil and silica by water can eliminate interfering substances. [33][34][35] As shown in Fig. 1, the baseline was smooth and the BDE-28 and BDE-47 chromatographic peaks could be distinguished clearly, when the deactivated silica gel was introduced.…”

Section: Sample Puricationmentioning

confidence: 92%

Determination of 25 polybrominated diphenyl ethers in Chinese mitten crab ecosystems by gas chromatography-mass spectrometry

Zhang¹,

Song²,

Wang³

et al. 2023

Anal. Methods

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“…Legacy BFRs, including polybrominated diphenyl ethers and biphenyls (PBDE, PBB, TBBPA), and hexabromocyclododecanes (HBCD) have been restricted due to their persistence, bioaccumulation, and toxicity [1]. Approximately 30 novel BFRs have recently emerged and their use is increasing [2][3][4][5]. Of note is the BFR 1,2-dibromo-4-(1,2 dibromoethyl) cyclohexane (TBECH), which has been shown to act an endocrine disruptor within the thyroid and gonadal axes [3,6, for review see 7], an embryotoxic agent [8,9], and a potential obesogen [10].…”

Section: Introductionmentioning

confidence: 99%

Electrical activity of osphradial neurons of the greater pond snail Lymnaea stagnalis is modulated by the brominated flame retardant 1,2-dibromo-4-(1,2 dibromoethyl) cyclohexane

Enns,

Tomy,

Fry

2024

Preprint

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Objective 1,2-dibromo-4-(1,2 dibromoethyl) cyclohexane (TBECH) is a brominated flame retardant used as a chemical additive in commercial and industrial manufacturing to reduce product flammability. TBECH has previously been shown to be an endocrine disruptor of the gonadal and thyroid axes, however, its neurotoxic effects, including effects on electrical excitability of neurons, are understudied. Therefore, we investigated the potential of TBECH to modulate electrical activity of neurons from the chemosensory osphradial organ of Lymnaea stagnalis using a suction electrode and extracellular recording.Results Application of TBECH caused a variable response in osphradial nerve spike activity, whereby some recordings showed increased action potential firing and some showed decreased firing. This resulted no significant change in mean action potential frequency after TBECH treatment compared to control (n = 6 separate experiments). However, using semi-automated spike sorting analysis to identify individual spike types from each recording revealed that the frequency of some spike types increased and some decreased within each nerve recording, and that TBECH caused significant modulation of activity. These findings indicate that TBECH may represent an acutely neurotoxic environmental contaminant that has potential to interfere with neural signaling in animals.

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Analysis of polybrominated diphenyl ethers, hexabromocyclododecanes, and legacy and emerging phosphorus flame retardants in human hair

Cited by 21 publications

References 39 publications

Quantitative Associations of Polluting Chemicals and Endogenous Biomolecules in Hair: An Observational Perspective from a Population-Based Study

Quantitative Associations of Polluting Chemicals and Endogenous Biomolecules in Hair: An Observational Perspective from a Population-Based Study

Determination of 25 polybrominated diphenyl ethers in Chinese mitten crab ecosystems by gas chromatography-mass spectrometry

Electrical activity of osphradial neurons of the greater pond snail Lymnaea stagnalis is modulated by the brominated flame retardant 1,2-dibromo-4-(1,2 dibromoethyl) cyclohexane

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