Analysis of polycyclic aromatic hydrocarbon intake in the US adult population from NHANES 2005–2014 identifies vulnerable subpopulations, suggests interaction between tobacco smoke exposure and sociodemographic factors

Gearhart-Serna, Larisa; Tacam, Moises; Slotkin, Theodore A.; Devi, Gayathri R.

doi:10.1016/j.envres.2021.111614

Cited by 10 publications

(4 citation statements)

References 32 publications

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“…The present findings strongly indicate an association between smoking and urinary 1-OHP concentration, with an odds ratio of 6.94, which was statistically significant in women and men, and is in agreement with the findings of previous studies [12,13,35,36]. This is not surprising, because each cigarette contains 3.2-16.0 ng benzo(a)pyrene [37].…”

Section: Discussionsupporting

confidence: 93%

“…Fur-thermore, numerous studies have reported an increase in the incidence of cardiovascular and respiratory diseases among women and children who lived around smokers [46,47]. As a cohort study in the United States, Gearhart-Serna et al [36] indicated that smoking and secondhand smoke exposure accounted for the largest PAH intake, and that there were strong interactions between race/ethnicity and smoking or second-hand smoke, especially in vulnerable populations for high PAH exposure. From the perspectives of human and environmental health, it is necessary to conduct a tailored health promotion program, including strategies to reduce cooking oil fumes by improving ventilation devices and methods to avoid secondhand smoke.…”

Section: Discussionmentioning

confidence: 99%

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Factors Associated with Urinary 1-Hydroxypyrene and Malondialdehyde among Adults near a Petrochemical Factory: Implications for Sex and Lifestyle Modification

Huang

Lin

et al. 2022

IJERPH

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Background: The association between the biomarkers of environmental exposure, oxidative stress, and health-related behaviors in community residents living in an endemic viral hepatitis area and near petrochemical industrial complexes remains unclear. From a health promotion perspective, healthcare providers must know what to do for residents concerned about their health and living environment, especially for individual-level and modifiable risk factors. Therefore, we aimed to explore the factors associated with urinary 1-hydroxypyrene (1-OHP) and malondialdehyde (MDA). Methods: A community-based, cross-sectional study was conducted between July 2018 and February 2019 in western coastal Yunlin County, Taiwan. All participants lived within a 10 km radius of a large petrochemical complex and did not work in the factory. This study was conducted with the local hospital through annual community health screening. Biological samples were collected and biomarkers determined and quantified in the central laboratory of the collaborating hospital. Results: A total of 6335 adult residents completed the study. The mean age was 47.7 (SD = 16) years. Out of the total population, 56.4% were female, 30.1% had metabolic syndrome (MetS), and 16.8% and 14.3% had hepatitis B virus antigen (HBsAg) and hepatitis C virus antibody (anti-HCV) positivity, respectively. The median 1-OHP and MDA level was 0.11 and 0.9 μg/g creatinine with an interquartile range of 0.07–0.18, and 0.4–1.5, respectively. The MDA levels correlated with specific diseases. The multivariable ordinal logistic regression model revealed that female sex, smoking, betel nut use, HBsAg, and anti-HCV positivity were associated with higher 1-OHP levels. In men, MetS was associated with higher 1-OHP levels and regular exercise with lower 1-OHP levels. High MDA levels were associated with smoking, betel nut users, HBsAg, and anti-HCV positivity. Conclusions: The findings highlight the importance of initiating individualized health promotion programs for residents near petrochemical factories, especially for adults with substance-use and cardiometabolic risk factors. Furthermore, it is crucial to provide further treatment to patients with viral hepatitis.

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Section: Discussionsupporting

confidence: 93%

Section: Discussionmentioning

confidence: 99%

Factors Associated with Urinary 1-Hydroxypyrene and Malondialdehyde among Adults near a Petrochemical Factory: Implications for Sex and Lifestyle Modification

Huang

Lin

et al. 2022

IJERPH

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“…PAHs, a common family of chemicals, exist in coal, crude oil, and gasoline naturally and are produced by burning coal, oil, natural gas, wood, garbage, and tobacco ( 13 ). PAHs can also be made by the high temperatures in cooking and combined with or form small pellets in the environment ( 14 ).…”

Section: Introductionmentioning

confidence: 99%

“…Sun et al reported that exposure to heavy metal mixtures was positively correlated with immune responses, and there were synergistic and antagonistic effects of intermetallic interactions on immune responses (11). A study based on experiments with mice showed that interactions between heavy metals affected autoimmune diseases (12).…”

Section: Introductionmentioning

confidence: 99%

The single and mixed impacts of cadmium, cobalt, lead, and PAHs on systemic immunity inflammation index in male and female

Nie,

Hu,

Xian

et al. 2024

Front. Public Health

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BackgroundStudies on the association between mixed exposure to common pollutants such as cadmium (Cd), cobalt (Co), lead (Pb), and polycyclic aromatic hydrocarbons (PAHs) with Systemic Immune Inflammatory Index (SII), a novel hemocyte-based inflammatory marker, have not been reported. This study explored the relationship between co-exposure to Cd, Co, Pb, PAHs, and SII.MethodsIn this study, we used data from the National Health and Nutrition Examination Survey and enrolled adults with complete information on Cd, Co, Pb, PAHs, and SII. The linear regression was used to analyze the association of single pollutants with SII. Furthermore, a Bayesian Kernel Machine Regression analysis and a generalized weighted quantile sum regression analysis were used to analyze the association between mixed exposure to Cd, Co, Pb, and six PAHs and SII. We also separated males and females and analyzed the different effects of pollutants on SII, respectively.Results5,176 participants were included in the study. After adjusting for age, gender, race, education, smoking, drinking, physical activity, and sedentary, Cd, Co, 1-OHN, 2-OHN and 2-OHF were positive with SII in the total population. Compared with the 50th percentile, the joint effect of pollutants on SII was positive. In the total population, males, and females, the top contaminant with the highest effect weights on SII were Co, Cd, and 1-OHN, respectively. The result of interaction analysis showed that the low concentrations of Cd had an elevation effect on SII in males.ConclusionThis study found a positive association of mixed exposure to Cd, Co, Pb, and six PAHs with SII, which occurred mainly in females.

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Association between co-exposure of polycyclic aromatic hydrocarbons and chronic obstructive pulmonary disease among the US adults: results from the 2013–2016 National Health and Nutrition Examination Survey

Wen

Ben

Yang

et al. 2023

Environ Sci Pollut Res

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Analysis of polycyclic aromatic hydrocarbon intake in the US adult population from NHANES 2005–2014 identifies vulnerable subpopulations, suggests interaction between tobacco smoke exposure and sociodemographic factors

Cited by 10 publications

References 32 publications

Factors Associated with Urinary 1-Hydroxypyrene and Malondialdehyde among Adults near a Petrochemical Factory: Implications for Sex and Lifestyle Modification

Factors Associated with Urinary 1-Hydroxypyrene and Malondialdehyde among Adults near a Petrochemical Factory: Implications for Sex and Lifestyle Modification

The single and mixed impacts of cadmium, cobalt, lead, and PAHs on systemic immunity inflammation index in male and female

Association between co-exposure of polycyclic aromatic hydrocarbons and chronic obstructive pulmonary disease among the US adults: results from the 2013–2016 National Health and Nutrition Examination Survey

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