Analysis of polymorphisms of genes associated with immune response and tissue remodeling in occupational chronic bronchitis

Akhmadishina, L. Z.; Korytina, G. F.; Кочетова, О. В.; Viktorova, Elena; Викторова, Т. В.

doi:10.1134/s1022795414110027

Cited by 5 publications

(3 citation statements)

References 33 publications

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“…For instance, SERPINA3 is one of the proteins in signal transduction pathways of the inflammatory response. A study of clinical relapsed ovarian tumors showed that the up-regulation of SERPINA3 was associated with disease progression and chemical resistance[16]. Moreover, another study showed that methylation of the 5' region may account for up-regulation of SERPINA3 in placental disease.…”

Section: Discussionmentioning

confidence: 99%

Clinical significance and role of up-regulation of SERPINA3 expression in endometrial cancer

Zhou¹,

Chen²,

Hui³

2019

WJCC

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BACKGROUND Serpin peptidase inhibitor, clade A member 3 (SERPINA3) belongs to the serpin family with an inhibitory activity against proteases. Its aberrant expression has been observed in a wide range of tumor cells. However, its clinical significance and biological function in endometrial cancer have been rarely studied. We designed a study to determine the levels of SERPINA3 and its significance in patients with endometrial cancer. AIM To investigate the clinical significance and role of SERPINA3 expression in endometrial cancer cells. METHODS Eighty endometrial tissue samples collected from patients with endometrial cancer were included in an observation group and 80 paraffin-embedded tissues samples collected from patients with normal endometrial tissues undergoing myomectomy were employed as a control group between January 2014 and December 2018. The expression of SERPINA3 mRNA was detected by quantitative polymerase chain reaction (PCR) for all endometrial tissues included in the study. RESULTS The positive expression rate of SERPINA3 protein in endometrial cancer cells was 71.25% in the observation group, which was significantly higher than that in the control group (31.25%; P < 0.05). There was no correlation between SERPINA3 protein in endometrial cancer cells and the age range at which women experienced menopause ( P > 0.05). However, it was associated with pathological grade, clinical stage, vascular invasion, and lymph node metastasis ( P < 0.05). Pathological grade, clinical stage, vascular invasion, and lymph node metastasis were independent prognostic factors for endometrial cancer. CONCLUSION The follow-up study of SERPINA3 can be used as a prognostic biomarker for endometrial cancer and as one of the targets for bio-targeted therapy for endometrial cancer.

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Section: Discussionmentioning

confidence: 99%

Clinical significance and role of up-regulation of SERPINA3 expression in endometrial cancer

Zhou¹,

Chen²,

Hui³

2019

WJCC

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“…Declining of proliferation and increasing the apoptosis of ASMCs in a rat model of allergic asthma can be caused by silencing of ADAM33 (20) . The genetic susceptibility to patients who get chronic bronchitis caused by smoking or aerosols and industrial dust can be enhanced by ADAM33 gene polymorphisms (21) .…”

Section: Discussionmentioning

confidence: 99%

Significant Association of Adam 33 Polymorphism with COPD in Javanese Population of Indonesia

Retno Ariza Soeprihatini Soemarwoto,

Jamsari,

Yanwirasti

et al. 2021

Indian Journal of Forensic Medicine & Toxicology

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Background: Chronic Obstructive Pulmonary Disease (COPD) is one of World health cases that is commonly known, which is triggered by the combination of environmental factors especially cigarette smoking and genetic factors. The association between A disintegrin and metalloprotease 33 (ADAM33) polymorphisms and COPD has been investigated and reported by other researchers. Objective: The main aim of this study is to identify the association between single nucleotide polymorphisms (SNPs) in ADAM 33 gene with COPD in the Javanese population in Lampung, Indonesia. Methods: A randomized cross-sectional study was used in this research. PCR-Sequencing method was involved to analyze the polymorphic for three SNPs (T1, T2, and Q-1) of the ADAM33 gene. Statistical analysis data was performed in descriptive and comparative as well as it was measured by parametric/non-parametric tests. Results: The results showed that the T2 GG, and T1AG genotypes in COPD group were significantly more frequent rather than in control group (p < 0.05). In case of allele, it was found that the T1G and T2G was higher in COPD group rather than in the control group (p = 0.440 and 0.131, respectively). Conclusion: The results clearly conclude that there was significant association between T1 and T2 polymorphisms of ADAM33 gene and COPD in the Javanese population of Lampung, Indonesia.

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“…In addition, rs1799750 in MMP1 was identified as associated with the mainly apical densitometric distribution of emphysema 124 , while the carriers of allele T of rs470358 are associated with the transference of gases in patients with COPD secondary to AATd 125 . Finally, polymorphisms in MMP1 have also been associated with the predisposition to occupational chronic bronchitis 126 .…”

Section: Genes Of Extracellular Mmps and Copdmentioning

confidence: 99%

Role of Genetic Susceptibility in Nicotine Addiction and Chronic Obstructive Pulmonary Disease

Pérez-Rubio

Córdoba-Lanús

Cupertino

et al. 2019

RIC

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Chronic obstructive pulmonary disease (COPD) is a leading cause of morbidity and mortality in developed countries. Although cigarette smoking is the major risk factor, only 10-20% of smokers develop COPD. The extent of cigarette smoking (pack-years and smoking duration) accounts for only 15% of the variation in lung function, indicating that differences in susceptibility to COPD must exist. We provide an overview of the complexity of nicotine addiction and COPD, with special attention to the involvement of genetic factors. The following aspects are discussed in the present article: (1) epidemiology in Mexico and (2) a review of the published literature on genetic association studies using the National Center for Biotechnology Information database of the United States as a search tool. COPD is unique among complex genetic diseases where an environmental risk factor is known and the level of exposure can be documented with some precision. The high morbidity and mortality associated with COPD and its chronic and progressive nature has prompted the use of molecular genetic studies to identify susceptibility factors for the disease. Biomedical research has a remarkable set of tools to aid in the discovery of genes and polymorphisms. We present a review of the most relevant genetic associations in nicotine addiction and COPD.

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Analysis of polymorphisms of genes associated with immune response and tissue remodeling in occupational chronic bronchitis

Cited by 5 publications

References 33 publications

Clinical significance and role of up-regulation of SERPINA3 expression in endometrial cancer

Clinical significance and role of up-regulation of SERPINA3 expression in endometrial cancer

Significant Association of Adam 33 Polymorphism with COPD in Javanese Population of Indonesia

Role of Genetic Susceptibility in Nicotine Addiction and Chronic Obstructive Pulmonary Disease

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