Analysis of polymorphisms of renin-angiotensin system and bradykinin receptor genes in children and adolescents with primary arterial hypertension

Abstract

We inspected 179 children and adolescents aged 9-17 years with primary arterial hypertension (AH) and 158 schoolchildren aged 7-17 years. All the hypertensive children underwent 24 hour ABPM. Family history of all the children was studied in particular of cardiovascular diseases. The 19-83G/A polymorphism of renin gene (REN), the M235T polymorphism of the angiotensinogen gene (AGT), the I/D polymorphism of angiotensin converting gene (ACE), the Al 166C polymorphism of angiotensin II type 1 receptor (AGTR1) gene, the C3123A polymorphism of angiotensin II type 2 receptor gene (AGTR2), I/D and T/С polymorphisms of the bradykinin receptor 2 gene (BKR2), were analyzed. We found out the significant increase of A allele and genotype AA of 19-83G/A polymorphism of gene REN frequencies of the children with stable AH in comparison with control group. In the group of children with stable hypertension - in comparison with the group of children, who has white coat hypertension and labile AH, we found out statistically significant prevalence of T allele the M235T polymorphism of the gene AGT. Distribution of I/D polymorphisms frequencies for ACE and BKR genes was similar in children and adolescents with primary AH compared to control group. The children with AH, who had relatives with coronary disease, had significant increase of A allele and genotype AA polymorphism A1166C of gene AGTR1 frequencies. We did not find out significant differences in distribution of A and С alleles of C3123A polymorphism of gene AGTR2 between the hypertensive children and control group. The males with AH had significant distribution difference of alleles polymorphism T58C gene BKR2 with allele С increase.