Analysis of population characteristics related to the total effective xenoestrogen burden: A biomarker of xenoestrogen exposure in breast cancer

Fernández, Mariana F.; Santa‐Marina, Loreto; Ibarluzea, Jesús; Expósito, José; Aurrekoetxea, Juan José; Torné, Pablo; Laguna, Juan Carlos; Rueda, A; Pedraza, Vicente; Olea, Nicolás

doi:10.1016/j.ejca.2007.03.010

Cited by 26 publications

(17 citation statements)

References 41 publications

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“…Industrial areas release environmental pollutants containing endocrine disruptors that affect women's health (Fernandez et al . ). Environmental chemical pollutants such as metals, dioxins, phthalates and Bisphenol‐A are known to cause breast cancer, uterus myoma, endometriosis, menstrual problems, infertility, abortion and early menopause (Mendola et al .…”

Section: Introductionmentioning

confidence: 97%

Development and validation of the pro‐environmental behaviour scale for women's health

Kim

2017

Journal of Advanced Nursing

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Section: Introductionmentioning

confidence: 97%

Development and validation of the pro‐environmental behaviour scale for women's health

Kim

2017

Journal of Advanced Nursing

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“…In addition, theoretically, functional tests can give estimates of total exposure to estrogenic activity or other forms of endocrine disruption; however, these methods are not yet well developed for use in biological samples. The MCF-7 cell proliferation assay has been used to measure estrogenic activity in extracts of adipose tissue in breast cancer cases and controls (Fernandez et al 2007). The development of methods to conduct this assay in blood, and to distinguish endogenous and exogenous estrogen signals, would allow integrated assessments of exposure to xenoestrogens.…”

Section: Resultsmentioning

confidence: 99%

“…Rather than measuring the level of an individual chemical, these methods can integrate effects of multiple agents and do not depend on a priori knowledge of each potentially relevant chemical. For example, some studies have sought to measure total exposure to exogenous estrogenic chemicals in adipose by using a functional in vitro assay for estrogenic activity (Fernandez et al 2007; Rasmussen et al 2003), and others have proposed a method to measure protein adducts formed by all reactive electrophiles (Rappaport et al 2012) or measures of oxidative stress and DNA damage (e.g., Arlt and Schwerdtle 2011). …”

Section: Discussionmentioning

confidence: 99%

New Exposure Biomarkers as Tools for Breast Cancer Epidemiology, Biomonitoring, and Prevention: A Systematic Approach Based on Animal Evidence

Rudel

Ackerman

Attfield

et al. 2014

Environ Health Perspect

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Background: Exposure to chemicals that cause rodent mammary gland tumors is common, but few studies have evaluated potential breast cancer risks of these chemicals in humans.Objective: The goal of this review was to identify and bring together the needed tools to facilitate the measurement of biomarkers of exposure to potential breast carcinogens in breast cancer studies and biomonitoring.Methods: We conducted a structured literature search to identify measurement methods for exposure biomarkers for 102 chemicals that cause rodent mammary tumors. To evaluate concordance, we compared human and animal evidence for agents identified as plausibly linked to breast cancer in major reviews. To facilitate future application of exposure biomarkers, we compiled information about relevant cohort studies.Results: Exposure biomarkers have been developed for nearly three-quarters of these rodent mammary carcinogens. Analytical methods have been published for 73 of the chemicals. Some of the remaining chemicals could be measured using modified versions of existing methods for related chemicals. In humans, biomarkers of exposure have been measured for 62 chemicals, and for 45 in a nonoccupationally exposed population. The Centers for Disease Control and Prevention has measured 23 in the U.S. population. Seventy-five of the rodent mammary carcinogens fall into 17 groups, based on exposure potential, carcinogenicity, and structural similarity. Carcinogenicity in humans and rodents is generally consistent, although comparisons are limited because few agents have been studied in humans. We identified 44 cohort studies, with a total of > 3.5 million women enrolled, that have recorded breast cancer incidence and stored biological samples.Conclusions: Exposure measurement methods and cohort study resources are available to expand biomonitoring and epidemiology related to breast cancer etiology and prevention.Citation: Rudel RA, Ackerman JM, Attfield KR, Brody JG. 2014. New exposure biomarkers as tools for breast cancer epidemiology, biomonitoring, and prevention: a systematic approach based on animal evidence. Environ Health Perspect 122:881–895; http://dx.doi.org/10.1289/ehp.1307455

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“…84 Chlorinated BPA has been detected in human adipose and placental tissues, dichlorinated BPA being the most abundant form. 85,86 Also, halogenated analogs of BPA, such as brominated and chlorinated BPAs, are produced today as flame retardants. The highly produced tetrabromobisphenol A (TBBPA) can be dehalogenated by microorganisms in contaminated sediments from streambeds to form BPA.…”

Section: Discussionmentioning

confidence: 99%

Gestational bisphenol A exposure and testis development

Williams

Bondesson

Krementsov

et al. 2014

Endocrine Disruptors

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Virtually all humans are exposed to bisphenol A (BPA). Since BPA can act as a ligand for estrogen receptors, potential hazardous effects of BPA should be evaluated in the context of endogenous estrogenic hormones. Because estrogen is metabolized in the placenta, developing fetuses are normally exposed to very low endogenous estrogen levels. BPA, on the other hand, passes through the placenta and might have distinct adverse consequences during the sensitive stages of fetal development. Testicular gametogenesis and steroidogenesis begin early during fetal development. These processes are sensitive to estrogens and play a role in determining the number of germ stem cells, sperm count, and male hormone levels in adulthood. Although studies have shown a correlation between BPA exposure and perturbed reproduction, a clear consensus has yet to be established as to whether current human gestational BPA exposure results in direct adverse effects on male genital development and reproduction. However, studies in animals and in vitro have provided direct evidence for the ability of BPA exposure to influence male reproductive development. This review discusses the current knowledge of potential effects of BPA exposure on male reproductive health and whether gestational exposure adversely affects testis development.

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Analysis of population characteristics related to the total effective xenoestrogen burden: A biomarker of xenoestrogen exposure in breast cancer

Cited by 26 publications

References 41 publications

Development and validation of the pro‐environmental behaviour scale for women's health

Development and validation of the pro‐environmental behaviour scale for women's health

New Exposure Biomarkers as Tools for Breast Cancer Epidemiology, Biomonitoring, and Prevention: A Systematic Approach Based on Animal Evidence

Gestational bisphenol A exposure and testis development

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