Analysis of Posttransplant Diabetes Mellitus Prevalence in a Population of Kidney Transplant Recipients

Bonato, V.; Barni, Roberto; Cataldo, Dorica; Collini, Andrea; Ruggieri, Giuliana; Bartolomeis, Carmine De; Dotta, Francesco; Carmellini, Mario

doi:10.1016/j.transproceed.2008.05.045

Cited by 40 publications

(32 citation statements)

References 4 publications

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“…In the present study, pretransplant BMI itself was not associated with the incidence of NODAT; however, several studies have previously reported this relationship (Cosio et al 2005;Joss et al 2007;Bonato et al 2008). It has already been reported that weight gain between time of transplantation and 3 months to 1 year after transplantation was not a risk factor for NODAT (Gourishankar et al 2004;Kuypers et al 2008;Roland et al 2008).…”

Section: Discussioncontrasting

confidence: 52%

“…In fact, lifestylechange intervention was reported to be highly effective for preventing type 2 diabetes in the general population (Helmrich et al 1991;Tuomilehto et al 2001;Knowler et al 2002). Body mass index (BMI) is the most frequently used diagnostic indication of obesity, and higher pretransplant BMI has been reported to be an independent risk factor of NODAT (Cosio et al 2005;Rodrigo et al 2005;Bonato et al 2008). However, the effect of increase in BMI on the incidence of NODAT has not yet been established.…”

Section: Introductionmentioning

confidence: 99%

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Posttransplant Increase of Body Mass Index is Associated with New-Onset Diabetes Mellitus after Kidney Transplantation

Tokodai

Amada

Kikuchi

et al. 2013

Tohoku J. Exp. Med.

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New-onset diabetes after transplantation (NODAT) is a serious complication after kidney transplantation. Obesity was widely identified as a modifiable risk factor for NODAT. Body mass index (BMI) is the most frequently used diagnostic indication of obesity, and higher pretransplant BMI has been reported to be an independent risk factor of NODAT. However, the influence of posttransplant increase in BMI on the development of NODAT during outpatient follow-up has not been established. This is a single-centered retrospective study in Japan. We identified 158 consecutive patients who received living donor kidney transplantation in Sendai Shakaihoken Hospital from September 2000 to December 2009. Of these, 101 patients were included in this study. NODAT was defined based on the American Diabetes Association definitions. Fifteen patients developed NODAT with a median follow-up period of 27 (3-109) months. Of these 15 patients with NODAT, 13 patients were diagnosed after the first year of transplantation, with a median follow-up of 29 months, and 2 patients were diagnosed at 3 months after transplantation. Recipient age (HR: 1.06 [1.01-1.13]) and increase in BMI (HR: 1.12 [1.01-1.26]) proved to be independent risk factors of NODAT in multivariate logistic analysis after adjustments for pretransplant 2-hour OGTT level, pretransplant BMI, and use of tacrolimus. This is the first study showing the association between an increase in BMI and the development of NODAT. The increase in BMI might be a risk factor for NODAT. These findings underline the importance of routine BMI measurements in medical practice.

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Section: Discussioncontrasting

confidence: 52%

Section: Introductionmentioning

confidence: 99%

Posttransplant Increase of Body Mass Index is Associated with New-Onset Diabetes Mellitus after Kidney Transplantation

Tokodai

Amada

Kikuchi

et al. 2013

Tohoku J. Exp. Med.

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“…24 The pattern of body fat distribution especially intra-abdominal fat or waist-tohip ratio have been found to be important risk factors for NODAT than total body weight or BMI. 19 …”

Section: Modifiable Risk Factors Obesitymentioning

confidence: 99%

New-Onset Diabetes after Transplant (NODAT)

Maskey

2015

Kathmandu Univ. Med. J.

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New onset diabetes mellitus after transplantation (NODAT) is a well known complication following solid organ transplantation and has been reported to occur in 4% to 25% of renal transplant recipients, 2.5% to 25% of liver transplant recipients, hepatitis C virus (HCV) infection between 40% and 60% and 2% to 53% of all solid organ transplants. This variation in the reported incidence may be because of lack of a universal agreement on the definition of NODAT, the duration of followup, and the presence of modifiable and non-modifiable risks factors. Moreover, reduced patient survival and accelerated graft loss have been reported with NODAT. In our country also there is increasing in number of kidney transplants patients and along with that there is chance of development of NODA. It is better to detect the NODATS early. So in this article I tried to presents an overview of the literature on the current diagnostic criteria for NODAT and discuss suggested risk factors for the development of NODAT, its potential pathogenic mechanisms, and its impact on post-transplant outcomes after solid organ transplantation.

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“…Во многих исследованиях показано, что избыточ-ный вес и ожирение связаны с развитием ПТСД [30]. Анализ базы USRDS показал, что индекс массы тела более 30 кг/м 2 является одним из самых значимых фак-торов риска развития ПТСД (относительный риск 1,85, p<0,0001), для реципиентов с ИМТ от 25 до 29,9 кг/м 2 от-носительный риск равен 1,39, р<0,0001 [31].…”

Section: метаболический синдромunclassified

Post-transplantation diabetes mellitus: an overview

et al. 2015

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© Сахарный диабет, 2015Вопросы патогенеза осттрансплантационный сахарный диабет (ПТСД) -частое осложнение после транс-плантации солидных органов. Пациенты с развившимся ПТСД имеют повышенный риск острого отторжения, инфекций, кардиоваскулярных событий, снижения долгосрочной выживаемости [1]. В США ме-дицинские затраты на реципиента почечного трансплан-тата с развившимся ПТСД увеличиваются на $21 500 [2].

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Analysis of Posttransplant Diabetes Mellitus Prevalence in a Population of Kidney Transplant Recipients

Cited by 40 publications

References 4 publications

Posttransplant Increase of Body Mass Index is Associated with New-Onset Diabetes Mellitus after Kidney Transplantation

Posttransplant Increase of Body Mass Index is Associated with New-Onset Diabetes Mellitus after Kidney Transplantation

New-Onset Diabetes after Transplant (NODAT)

Post-transplantation diabetes mellitus: an overview

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