Analysis of prenatal and postnatal risk factors of retinopathy of prematurity in a tertiary care hospital in South India

Rao, Krishna; Purkayastha, Jayashree; Hazarika, Manali; Chaitra, R; Adith, K Mithun

doi:10.4103/0301-4738.119347

Cited by 28 publications

(9 citation statements)

References 14 publications

(18 reference statements)

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“…328 These results have been replicated in multiple subsequent studies, both for the risk of incident ROP and of treatment-requiring ROP. 6,10,11,13,14,17,18,21,47,57,65,75,77,94,102,109,114,122,125,135,138,143,147,152,157,174,202,204,216,228,231,233,236,240,246,255,263,266,271,276,282,283,285,308,311,312,315,335,337,348,362,367,371,373,378,391,398,405,406,410,412,418…”

Section: Major Risk Factorsmentioning

confidence: 99%

“…269 IVH occurs in 25–30% of all preterm infants <1,500 g. 344 For unclear reasons, IVH has repeatedly been associated with ROP and appears in many of the articles reviewed. 12,14,23,35,58,68,76,122,174,220,235,266,272,311,336,337,387,395,398,405,414,415 An epidemiologic analysis of 2,950 infants in Turkey revealed that any IVH was associated with greater risk of ROP. 23…”

Section: Alternative Risk Factorsmentioning

confidence: 99%

See 1 more Smart Citation

Retinopathy of prematurity: a review of risk factors and their clinical significance

Kim

Port

Swan

et al. 2018

Survey of Ophthalmology

419

337

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Retinopathy of prematurity (ROP) is a retinal vasoproliferative disease that affects premature infants. Despite improvements in neonatal care and management guidelines, ROP remains a leading cause of childhood blindness worldwide. Current screening guidelines are primarily based on two risk factors: birth weight and gestational age; however, many investigators have suggested other risk factors, including maternal factors, prenatal and perinatal factors, demographics, medical interventions, comorbidities of prematurity, nutrition, and genetic factors. We review the existing literature addressing various possible ROP risk factors. Although there have been contradictory reports, and the risk may vary between different populations, understanding ROP risk factors is essential to develop predictive models, to gain insights into pathophysiology of retinal vascular diseases and diseases of prematurity, and to determine future directions in management of and research in ROP.

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Section: Major Risk Factorsmentioning

confidence: 99%

Section: Alternative Risk Factorsmentioning

confidence: 99%

Retinopathy of prematurity: a review of risk factors and their clinical significance

Kim

Port

Swan

et al. 2018

Survey of Ophthalmology

419

337

View full text Add to dashboard Cite

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“…The incidence of ROP reported in India varies between 2.4% and 42% among screened infants, with study population varying from less than 32 to 34 weeks and birth weight less than 1,500 to 2,000 g. [4][5][6][7][8][9][10][11][12][13][14][15] The special neonatal care units (SNCUs), which are the cornerstone of sick and LBW neonates in India report a 15% incidence of sight-threatening (ST ROP), that is, ROP requiring intervention. 6 Globally the reported incidence is between 15.2% and 42.7%.…”

Section: Discussionmentioning

confidence: 99%

“…2 Since ROP was first described over 75 years ago, there have been a conglomerate of papers that identify distinct putative risk factors and interventions to prevent ROP. [3][4][5][6][7][8][9][10][11][12][13] Previous studies from the authors' reported various risk factors of which significant ones were prematurity, low birth weight (LBW), and lack of antenatal steroids. 14,15 Multiple We hypothesized that clinical stability provided by KMC would lead to a reduction in any stage of ROP and severity of ROP in neonates who receive effective KMC during a hospital stay.…”

Section: Introductionmentioning

confidence: 99%

Effect of Kangaroo Mother Care on Retinopathy of Prematurity in Neonates Less Than 1,800 g or Below 34 Weeks of Gestation

Singh,

Arya,

Chellani

et al. 2024

Journal of Neonatology

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Introduction KMC (Kangaroo Mother Care) is an established intervention to reduce mortality and morbidity in low birth weight (LBW) neonates. A multitude of risk factors and preventive strategies for ROP (retinopathy of prematurity) have been studied, however, the effect of KMC on ROP has not been reported. This study aims to study the effect of KMC on ROP in neonates with birth weights between 1,000 and 1,800 g. Methods The babies who received effective KMC (>6 hours per 24 hours for three consecutive days) were analysed in the intervention group and those with ineffective KMC were analysed in the control group. Variables significant in univariate analysis were entered into backward regression models in multivariate analysis. Odds ratios and 95% confidence intervals were calculated. P values < .05 are taken as significant. Results Of 783 neonates enrolled, 66 (8.4%) developed ROP (any stage). The incidence of ROP requiring intervention was 1.02%. Effective KMC reduced the risk of ROP by 95%, RR 0.05 (0.02–0.12) and number needed to treat = 5. The proportion of neonates with ROP in zone 1 and stage 3 was more in the ineffective KMC (42.4% vs. 1.5%) group than in the effective KMC group (51.5% vs. 0%) ( P < .001). Ineffective KMC, gestation <30 weeks, small for gestation, obstetric complications, asphyxia, sepsis, higher initial PEEP and lack of breastfeeding were significant risk factors for developing ROP. Conclusion KMC, an effective intervention to improve the mortality and morbidity in LBW neonates, was significantly associated with the reduction of any stage ROP and ROP needing intervention, potentially preventing a significant cause of childhood blindness.

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“…There is conflicting evidence on whether multiple pregnancy increases the risk of ROP[26] with some studies finding no difference[2728] whereas others have reported an increased risk. [2930] We did not find a significant difference in our study.…”

Section: Discussionmentioning

confidence: 99%

Comparison of retinopathy of prematurity incidence between Turkish citizens and Syrian refugees

Kimyon

Çelemler

Mete

et al. 2019

Indian J Ophthalmol

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Purpose: More than 3.5 million Syrians came to Turkey seeking refuge and over 470,000 Syrian infants were born since the start of the civil war in 2011. Our aim is to compare the incidence of retinopathy of prematurity (ROP) between Syrian refugees and Turkish citizens. Methods: This multicenter, retrospective study was conducted in Gaziantep University, Faculty of Medicine and Gaziantep Children's Hospital in Turkey. We included the data of patients who were screened for ROP between July 2015 and June 2017. Results: The above-mentioned data of 906 Turkish infants and 199 Syrian infants were included in this study. Mean gestational ages (GAs) were (32.9 ± 2.7) and (32.1 ± 2.8) weeks as well as mean birth weights (BWs) were (1937.5 ± 582.9) and (1696.8 ± 485.5) g, in Turkish and Syrian infants, respectively. GA and BW were significantly lower in Syrian infants while time spent in neonatal intensive care unit was significantly higher. The zone of ROP was lower in the Syrian infants in the first examination and for the most advanced ROP ( P = 0.001). Any stage ROP was present in 392 (43.3%) and 81 (40.7%) patients in Turkish and Syrian population, respectively ( P = 0.490). The number of patients who required treatment for ROP were 95 (10.5%) and 20 (10.1%) in Turkish and Syrian groups, respectively ( P = 0.882). Conclusion: Our findings showed that refugee infants had lower BW and GA than native population but the incidence of ROP did not differ between them. Psychosocial stress is an important risk factor for women at reproductive age as it increases the incidence of prematurity. Additional care and psychological support must be given to refugees during perinatal period to decrease the risk of premature birth.

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Analysis of prenatal and postnatal risk factors of retinopathy of prematurity in a tertiary care hospital in South India

Cited by 28 publications

References 14 publications

Retinopathy of prematurity: a review of risk factors and their clinical significance

Retinopathy of prematurity: a review of risk factors and their clinical significance

Effect of Kangaroo Mother Care on Retinopathy of Prematurity in Neonates Less Than 1,800 g or Below 34 Weeks of Gestation

Comparison of retinopathy of prematurity incidence between Turkish citizens and Syrian refugees

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