Analysis of primary oral and oropharyngeal squamous cell carcinoma in inhabitants of Beijing, China—a 10-year continuous single-center study

Abstract

Background: This study aimed to describe some of the characteristics of the inhabitants of Beijing with oral and oropharyngeal squamous cell carcinoma (OSCC) who had received treatment at the Stomatology Hospital of Peking University and to analyze the survival rate and the prognostic factors of patients following surgical treatment. Methods: Data for 603 consecutive cases with primary OSCC between 2004 and 2013 were obtained from the Stomatology Hospital of Peking University. Clinical data including age, sex, living district, primary tumor site, TNM stage, history of drinking and smoking, pathological differentiation, treatment, and survival were retrospectively analyzed. Results: The male:female ratio was 1.1:1. The frequency of site involvement in descending order was tongue (34.3%), gingiva (25.0%), buccal mucosa (13.8%), oral floor (9.0%), oropharynx (8.5%), lip (6.3%) and palate (3.2%). Female OSCC patients tended to be significantly older than men with OSCC (P < 0.05). The percentage of patients with TNM stage III-IV OSCC was 52.4%. The results revealed that 65.3% of male patients and only 6.3% of female patients smoked or drank. The overall 5-year survival rate was 64%. Female patients had a worse prognosis than male patients. Among the patients who received surgery, tumor size and lymph node involvement were independent prognostic factors. Smoking and drinking were not prognostic factors. Conclusion: Among the Beijing inhabitants who were diagnosed with OSCC and treated in our hospital in the past 10 years, more than half were in the advanced stage, and the cancer stage was the main prognostic factor of oral cancer. Therefore, the recognition of oral cancer should be strengthened, and early detection and treatment of OSCC should be achieved to improve the survival rate.

Epidemiology and survival outcomes of lip, oral cavity, and oropharyngeal squamous cell carcinoma in a southeast Brazilian population

“…( 1 ) (HR: 1.82; 95% CI, 1.18-2.78) for OSCC. Individuals diagnosed with lip SCC (HR: 1.97; 95% CI, 1.32-2.95), OSCC (HR: 2.19; 95% CI, 1.88-2.55), and OPSCC (HR: 2.51; 95% CI, 2.09-3.00) with advanced-stage (stages III-IV) tumours were more likely to die than patients with early-stage disease, which was an important independent determinant of OS, corroborating the findings reported in earlier studies ( 7 , 8 , 15 , 22 , 27 ).…”

“…When lip SCC was exclusively analysed, previous studies reported that the lower lip was the most commonly affected site ( 10 , 15 , 23 ), similar to our findings. In the oral cavity, according to previous reports ( 7 , 9 , 14 , 22 ) and our results, the tongue (excluding the base of the tongue) was the most commonly affected subsite. However, in India and surrounding countries, the most frequent subsite of OSCC was the buccal mucosa, as a repercussion of the habit of chewing tobacco ( 24 ).…”

Hormone receptors AR, ER, PR and growth factor receptor Her-2 expression in oral squamous cell carcinoma: Correlation with overall survival, disease-free survival and 10-year survival in a high-risk population

“…Long-term survival analysis allows the assessment of several clinicopathologic parameters over the period of time, and to evaluate their changing influence on patient mortality. A single-centre study of China has reported a decrease in survival rate from 71% at 3-year, to 64% at 5-year and 54% at 10-years for OSCC [ 30 ].…”

The Ratio of Preoperative Serum Biomarkers Predicts Prognosis in Patients With Oral Squamous Cell Carcinoma

“…According to previous studies, the prognosis of OSCC is highly heterogeneous, with an overall 5-year survival rate of approximately 64%, and the median survival duration for patients with locoregionally recurrent or metastatic OSCC is 8~10 months (31,32). Oral malignancies progress through four stages; in the early stage (stages I and II), the 5-year survival rate is approximately 80%.…”