Analysis of publications on paratuberculosis from 1995 to 2009  with emphasis on the period from 2005 to 2009

Kaevska, Marija; Hruška, K.

doi:10.17221/19/2010-vetmed

Cited by 6 publications

(1 citation statement)

References 16 publications

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“…Citations retrieved from all databases were imported into reference management software Procite v. 5.0.3 (ISI Researchsoft, 1995) and de-duplicated. Search verification was twofold; first, reference lists of review articles [6, 27–31] and three SRs published on M. paratuberculosis [21–23] were searched by hand. Second we identified all citations relevant to this SR during relevance screening for a scoping review on sources of M. paratuberculosis being conducted at the same time to identify any potentially missed citations.…”

Section: Methodsmentioning

confidence: 99%

The zoonotic potential ofMycobacterium aviumssp.paratuberculosis: a systematic review and meta-analyses of the evidence

et al. 2015

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This systematic review-meta-analysis appraises and summarizes all the available research (128 papers) on the zoonotic potential of Mycobacterium avium ssp. paratuberculosis. The latter has been debated for a century due to pathogenic and clinical similarities between Johne's disease in ruminants and Crohn's disease (108 studies) in humans and recently for involvement in other human diseases; human immunodeficiency virus (HIV) infection (2), sarcoidosis (3), diabetes mellitus type 1 (T1DM) (7) and type 2 (3), multiple sclerosis (5) and Hashimoto's thyroiditis (2). Meta-analytical results indicated a significant positive association, consistently across different laboratory methods for Crohn's disease [odds ratio (OR) range 4·26-8·44], T1DM (OR range 2·91-9·95) and multiple sclerosis (OR range 6·5-7·99). The latter two and the thyroiditis hypothesis require further investigation to confirm the association. Meta-regression of Crohn's disease studies using DNA detection methods indicated that choice of primers and sampling frame (e.g. general population vs. hospital-based sample) explained a significant proportion of heterogeneity. Other epidemiological studies demonstrated a lack of association between high-risk occupations and development of Crohn's disease. Due to knowledge gaps in understanding the role of M. paratuberculosis in the development or progression of human disease, the evidence at present is not strong enough to inform the potential public health impact of M. paratuberculosis exposure.

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