Analysis of reactivation of hepatitis B virus in the treatment of B cell non-Hodgkin’s lymphoma in Hokkaido

Hepatitis B virus reactivation with rituximab-containing regimen

“…Our results involving a survey at a hematology institute in Hokkaido showed that reactivation only developed when rituximab was used. This result is consistent with another study by Yeo et al [31] that suggested that rituximab increases the chance of HBV reactivation more than chemotherapy alone [14,31] . Rituximab is more likely to induce HBV reactivation in combination with chemo-or steroid-therapies, since it alone increases the chance of HBV reactivation.…”

“…Reactivation is often associated with the chemotherapy given for lymphomas and is probably influenced by steroids [26,30] . Upon the introduction of rituximab, it was initially debated whether rituximab alone or combined with chemotherapy could induce HBV reactivation and our subsequent study, as well as work by Yang et al [22] , reported HBV reactivation after rituximab alone, suggesting that rituximab itself, without chemotherapy, can induce HBV reactivation [14,22] . Although rituximab is more likely to induce HBV reactivation in combination with chemo-or steroidtherapies, since it alone can induce HBV reactivation, caution must be exercised in its use [14] .…”

“…One such complication is the reactivation of hepatitis B virus (HBV), an important problem that was sometimes observed with chemotherapy treatments even before the introduction of rituximab [8][9][10][11][12] . The deleterious effects of HBV reactivation in rituximab-containing chemotherapy regimens have been reported and the effect of lamivudine treatment in the prevention of HBV reactivation is also well documented [13][14][15][16][17] . Several issues remain, including the optimal timing and the treatment length of preventive lamivudine and the follow-up range of patients who are responsive to this treatment.…”

Effect of Antiviral Prophylaxis Strategy for Chemotherapy-Associated Hepatitis B Reactivation in Non-Hodgkin’s Lymphoma Patients with Hepatitis B Virus Infection: A Retrospective Cohort Study

“…But it is also interesting to note that a larger proportion in patients having rituximab-containing regimens received routine antiviral prophylaxis, and that likely contributed to the result. Since the initial use of rituximab in the clinic, a number of cases of HBV reactivation after rituximab administration have been reported previously [26,27]. Moreover, it has been suggested that rituximab may augment the risk of reactivation compared to chemotherapy alone [12,28,29].…”

GENNO-INZhENERNYE BIOLOGIChESKIE PREPARATY I VIRUSNYY GEPATIT V U BOL'NYKh REVMATOIDNYM ARTRITOM

“…Было установлено, что реактивация ВГВ была связа-на с применением ритуксимаба как в виде монотерапии, так и в сочетании с другими химиопрепаратами. Из 829 больных HBsAg был обнаружен у 50, причем 25 из них по-лучали ритуксимаб (5 -в виде монотерапии) [42].…”