Field experience has demonstrated that infill well fractures tend to propagate towards the primary well, resulting in well-to-well interference, or so-called “frac-hits”. Frac-hits are a major concern in horizontal well refracturing because they adversely affect the productivity of both wells. This paper provides a 3D geomechanical study of the problem for the first time in order to better understand frac-hits in horizontal well refracturing and its mitigating solutions. To our knowledge, this is the only refracturing study focused on fracture mechanics and within the context of coupled proroelasticity using a single model. The modeling is based on the fully coupled 3D model, GeoFrac-3D, which is capable of simulating multistage fracturing of multiple horizontal wells. The model couples pore pressure to stresses, and makes it possible to create dynamic models of fracture propagation. The modeling results show that production from production well fractures leads to a nonuniform reduction of the reservoir pore pressure around the production well and in between fractures, leading to an anisotropic decrease of the total stress, potentially resulting in stress reorientation and/or reversal. The decrease in the total stress components in the vicinity of the production fractures creates an attraction zone for infill well hydraulic fractures. The infill well fractures tend to grow asymmetrically towards the lower stress zone. The risk of frac-hits and the impact on the “parent” and “infill” well production vary according to the reservoir stress regime, in situ stress anisotropy, and production time. By optimizing well and fracture spacing, fracturing fluid viscosity, and the timing of refracturing job, frac-hit problems can be minimized. The simulation results demonstrate that the risks of frac-hits can be potentially mitigated by repressurization of the production well fractures before fracturing the infill well.