Buckling of the plates is of great importance in design of structures. If the plate has a hole because of necessity, hole area and shape also affect the critical buckling loads. In this study, buckling analyses of perforated simply supported square plates with various perforation patterns and different loading types were investigated. Three different perforation patterns as circular, hexagonal and square with different orientations were considered. In order to investigate the slenderness ratio effect, samples were calculated with three different ratio values of 100, 20 and 10. The samples were loaded with four different in-plane loads to examine the effect of loading type. Analyses were performed by using a general purpose finite element program and critical buckling loads were determined depending on the orientation angles for square plate models with different hole perforations. The critical buckling load is independent from the orientation angle for circular perforated plates but depends on for hexagonal and square hole perforations. For these plates buckling analyses were performed for different orientation angles of 0 degrees to 90 degrees. The results show that the calculated critical buckling loads did not remain the same although the hole areas were the same.