Background: The aim of this report is to report the effect of Acupotomy on Guillain-Barre Syndrome. Methods: A 38-year-old male patient was diagnosed with Guillain-Barre syndrome and complained of facial paralysis, weakness in the legs, pain in the back of the neck, headaches, and dizziness. This patient received acupotomy treatment on the suboccipital muscles and T5 spinous process inferior part. Results: After five sessions of acupotomy treatment from March 10th to April 3rd, the patient's facial paralysis improved to the point where there was no problem with facial expressions. The Y-score also improved from a total score of 20 to 40. In addition, the MMT index for weakness in the legs improved from 4 to 5, and the patient's other symptoms also improved. The NRS for headaches and other symptoms decreased from 8 to 3, remaining only mild. Conclusion: This study suggests that acupotomy treatment may be effective in alleviating limb weakness, facial paralysis, headaches, and other pains in patients with Guillain-Barre syndrome.