Analysis of Respiratory Movement of Lung Tumors on a Large Sample: Patterns and Factors Influencing Precise ITV Definition

Abstract

and progesterone receptor status, HER2 and ki67 (cut-off of 20%), cancer subtypes were as follows: luminal A, 147 pts (58.6%); luminal B-HER2 pos, 23 pts (9.2%); luminal B-HER2 neg, 24 pts (9.6%); HER2 pos, 21 pts (8.4%); basal, 23 pts (9.2%), undetermined, 13 pts (5.2%). Four patients failed in the ipsilateral breast after a median time of 3.2 yrs (range: 1.7-5.7 yrs) for a 5-yr IBTR-free survival of 98.7+0.7%. No clear trends or associations were detected between IBTR and age, grading, tumor subtype, pT or pN stage. Four patients developed distant metastases and, of them, 2 died of disease. Five-yr DM-free survival is 98.1 + 0.1%. Five patients developed a contralateral breast cancer, 4 infiltrative and 1 ductal carcinoma in situ after a median time of 3.8 yrs (range: 0.8-6.7 yrs). Five-yr CBRT-free survival is 98.7 + 0.7%. Thirteen patients developed a second primary tumor (which was lethal in 3) and 3 additional patients died of intercurrent disease. Five-yr overall and progression free survival are 96.7 + 1.3 and 91.6 + 1.9%, respectively. Conclusion: We demonstrated remarkably high local control rates with an 11-fx schedule irrespective of known adverse predictive factors.