Analysis of rimantadine hydrochloride by near-ir spectroscopy

Титова, А. В.; Арзамасцев, А. П.; Gretskii, S. V.

doi:10.1007/s11094-009-0344-6

Cited by 5 publications

(2 citation statements)

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“…Because of these potential risks, AMA has been banned in livestock farming by USA and China since 2005 [ 6 , 7 ]. So far, lots of assays have been reported for the detection of AMA, including near-infrared spectroscopy [ 8 , 9 ], HPLC-MS/GC-MS [ 6 , 10 , 11 , 12 , 13 , 14 , 15 , 16 ], micellar electrokinetic chromatography (MEKC) [ 17 ], capillary electrophoresis [ 18 , 19 ], and potentiometry [ 20 , 21 ]. However, those methods normally require complicated, expensive equipment and labor-intensive sample preparation procedures.…”

Section: Introductionmentioning

confidence: 99%

A Highly Selective and Strong Anti-Interference Host-Guest Complex as Fluorescent Probe for Detection of Amantadine by Indicator Displacement Assay

et al. 2018

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Amantadine (AMA) and its derivatives are illicit veterinary drugs that are hard to detect at very low concentrations. Developing a fast, simple and highly sensitive method for the detection of AMA is highly in demand. Here, we designed an anthracyclic compound (ABAM) that binds to a cucurbit[7]uril (CB[7]) host with a high association constant of up to 8.7 × 108 M−1. The host-guest complex was then used as a fluorescent probe for the detection of AMA. Competition by AMA for occupying the cavity of CB[7] allows ABAM to release from the CB[7]-ABAM complex, causing significant fluorescence quenching of ABAM (indicator displacement assay, IDA). The linear range of the method is from 0.000188 to 0.375 μg/mL, and the detection limit can be as low as 6.5 × 10−5 μg/mL (0.35 nM). Most importantly, due to the high binding affinity between CB[7] and ABAM, this fluorescence host-guest system shows great anti-interference capacity. Thus, we are able to accurately determine the concentration of AMA in various samples, including pharmaceutical formulations.

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Section: Introductionmentioning

confidence: 99%

A Highly Selective and Strong Anti-Interference Host-Guest Complex as Fluorescent Probe for Detection of Amantadine by Indicator Displacement Assay

et al. 2018

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“…coupled to either mass spectrometric detection or after derivatization prior to detection . Less demanding pharmaceutical quality control applications can be performed by batch spectrofluorimetry , near‐IR spectroscopy , and CE with simple indirect detection .…”

Section: Introductionmentioning

confidence: 99%

Determination of rimantadine in human urine by HPLC using a monolithic stationary phase and on-line post-column derivatization

2013

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In the present study, we propose the first HPLC method coupled to postcolumn derivatization for the determination of rimantadine in human urine samples. The analyte and amantadine (internal standard) were isocratically separated using an RP monolithic stationary phase (100 × 4.6 mm id) with a mobile phase consisting of CH3OH/phosphate buffer (25 mmol/L, pH 3.0) at a volume ratio of 50:50. Postcolumn derivatization involved on-line reaction with o-phthalaldehyde (20 mmol/L) and N-acetyl-cysteine (5 mmol/L) at alkaline medium (100 mmol/L borate pH 11.0). Spectrofluorimetric detection at λ(ex)/λ(em) = 340/455 nm enabled the selective and sensitive determination of rimantadine in urine samples at a range of 50-500 ng/mL with an LOD of 5 ng/mL. Human urine samples were analyzed successfully after SPE using hydrophilic-lipophilic balanced RP cartridges (30 mg/mL, Oasis HLB). Recoveries ranged between 89.7 and 102.7%.

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A combined study on structures and vibrational spectra of the antiviral rimantadine using SQMFF and DFT calculations

Iramain

Hidalgo

Sundius

et al. 2022

Heliyon

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Analysis of rimantadine hydrochloride by near-ir spectroscopy

Abstract: The possibility of using near-IR spectroscopy and discriminant analysis for the identification of rimantadine hydrochloride substance and determination of the substance and tablet manufacturers has been studied.

Cited by 5 publications

References 2 publications

A Highly Selective and Strong Anti-Interference Host-Guest Complex as Fluorescent Probe for Detection of Amantadine by Indicator Displacement Assay

A Highly Selective and Strong Anti-Interference Host-Guest Complex as Fluorescent Probe for Detection of Amantadine by Indicator Displacement Assay

Determination of rimantadine in human urine by HPLC using a monolithic stationary phase and on-line post-column derivatization

A combined study on structures and vibrational spectra of the antiviral rimantadine using SQMFF and DFT calculations

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