Analysis of risk factors associated with early multinodular recurrences after hepatic resection for hepatocellular carcinoma

Park, Jung Ho; Koh, Kwang Cheol; Choi, Myung Ja; Lee, Joon Hyoek; Yoo, Byung Chul; Paik, Seung Woon; Rhee, Jong Chul; Joh, Jae‐Won

doi:10.1016/j.amjsurg.2005.11.010

Cited by 100 publications

(74 citation statements)

References 20 publications

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“…In the present study, we found that vascular invasion, high Edmondson grade, large tumor size and high serum AFP levels were associated with early death. These data was mostly consistent with previous reports (Regimbeau et al 2004;Park et al 2006;Moriguchi et al 2012). Generally, there was a correlation between tumor differentiation and tumor size, and they both were predictors of microvascular invasion (Ker et al 2003).…”

Section: Discussionsupporting

confidence: 92%

“…Tumor thrombus tends to form in the portal vein, as it is the main outflow vessel of the tumor. It is generally accepted that HCC with portal vein tumor thrombi is associated with early intrahepatic recurrence and poor prognosis (Park et al 2006). Among the tumor-related factors that are typically associated with early death after hepatectomy, only poor tumor differentiation predicted an adverse outcome beyond 2 years after hepatectomy in logistic multivariate analysis.…”

Section: Discussionmentioning

confidence: 99%

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Postoperative Transarterial Chemoembolization Benefits Patients with High γ-Glutamyl Transferase Levels after Curative Hepatectomy for Hepatocellular Carcinoma: A Survival Stratification Analysis

Liu

Zhang

Qian

et al. 2012

Tohoku J. Exp. Med.

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Hepatocellular carcinoma (HCC) is the most common liver tumor in Asian countries, and hepatectomy is currently regarded as the optimal curative treatment for HCC; however, the postoperative outcome remains unsatisfactory. Aiming at further clarification of prognostic factors after hepatectomy, we adopted a detailed stratification on survival periods. A total of 428 HCC patients undergoing curative hepatectomy were firstly divided into two groups using 2-year survival as cutoff point. Multivariate analysis showed that tumor-related factors, including vascular invasion (P < 0.001), high Edmondson grade (P < 0.001), large tumor size (P < 0.001) and high serum alpha-fetoprotein level (P = 0.001), were significant determinants for early death within 2 years, while postoperative transarterial chemoembolization (TACE) was demonstrated a protective factor (P = 0.013). Then the 281 patients with survival > 2 years were divided into two subgroups according to survival or death during follow-up to examine the late death related factors. We found that high serum γ-glutamyl transpeptidase (GGT), indicating severity of underlying liver disease, was significantly linked to death in this stage (P = 0.006). In further comparison of survival rates between subgroups stratified by early-and late-death indictors, we found the long-term outcomes of patients with high serum GGT were poor, regardless of the factors related with primary tumor. Furthermore, postoperative TACE decreased late death rate of patients with high GGT levels. In conclusion, despite the overwhelmed effects of primary tumor in the early stage after hepatectomy, postoperative TACE is beneficial for HCC patients with poor liver status.

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Section: Discussionsupporting

confidence: 92%

Section: Discussionmentioning

confidence: 99%

Postoperative Transarterial Chemoembolization Benefits Patients with High γ-Glutamyl Transferase Levels after Curative Hepatectomy for Hepatocellular Carcinoma: A Survival Stratification Analysis

Liu

Zhang

Qian

et al. 2012

Tohoku J. Exp. Med.

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“…It is well known that vein invasion, multiple tumor nodes, poor cell differentiation, and TNM classification are highly correlated with invasion and metastasis and with a poor prognosis in patients who have HCC. [38][39][40][41] Our current study indicates that the up-regulated expression of PIRH2 is correlated with poor survival for patients with HCC. It is noteworthy that, whereas our univariate analysis indicated that high PIRH2 expression, multiple tumor nodes, and TNM classification were risk factors for prognosis in patients with HCC, our multivariate Cox regression analysis indicated that high PIRH2 expression and multiple tumor nodes were the only independent risk factors of prognosis for patients with HCC.…”

Section: Discussionmentioning

confidence: 98%

p53‐induced RING‐H2 protein, a novel marker for poor survival in hepatocellular carcinoma after hepatic resection

Wang

Yang

Guo

et al. 2009

Cancer

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Novel copolyacrylates containing various molar ratios of 5,10,15‐tri[p‐(9‐methoxy‐triethylenoxy)phenyl]‐20‐(p‐acryloxyphenyl)porphyrin units in the chains have been synthesized, and their chemical structure was determined by NMR and MALDI‐TOF mass spectrometry. Sensing response of the synthesized copolymers has been tested for trifluoroacetic and hydrochloric acids and nitrogen dioxide analytes. The reported sensing data indicate that porphyrin units are interacting with analytes in a reversible fashion. © 2010 Wiley Periodicals, Inc. J Polym Sci Part A: Polym Chem, 2011

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“…HCC is characterized by a high incidence of intrahepatic recurrence, including intrahepatic metastasis and multicentric occurrence, even after curative treatment (6)(7)(8)(9); therefore, most patients with recurrent HCC need to be treated repeatedly. Although hepatic resection and radiofrequency ablation (RFA) are recognized as curative treatments, many cirrhotic patients cannot repeatedly undergo curative treatments due to the deterioration of liver function after treatment.…”

Section: Sequelae Of Chronic Infection With Hepatitis B Virus (Hbv) Imentioning

confidence: 99%

Nucleotide Analogs for Patients with HBV-Related Hepatocellular Carcinoma Increase the Survival Rate through Improved Liver Function

et al. 2009

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Analysis of risk factors associated with early multinodular recurrences after hepatic resection for hepatocellular carcinoma

Cited by 100 publications

References 20 publications

Postoperative Transarterial Chemoembolization Benefits Patients with High γ-Glutamyl Transferase Levels after Curative Hepatectomy for Hepatocellular Carcinoma: A Survival Stratification Analysis

Postoperative Transarterial Chemoembolization Benefits Patients with High γ-Glutamyl Transferase Levels after Curative Hepatectomy for Hepatocellular Carcinoma: A Survival Stratification Analysis

p53‐induced RING‐H2 protein, a novel marker for poor survival in hepatocellular carcinoma after hepatic resection

Nucleotide Analogs for Patients with HBV-Related Hepatocellular Carcinoma Increase the Survival Rate through Improved Liver Function

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