Analysis of Risk Factors for Lower-limb Deep Venous Thrombosis in Old Patients after Knee Arthroplasty

Kang, Jian; Jiang, Xu

doi:10.4103/0366-6999.156782

Cited by 32 publications

(37 citation statements)

References 24 publications

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“…In our study, we had the similar conclusion and also found in multivariate analysis that age, malignant tumor, hypertension were independent risk factors of DVT. Patients with older age are often associated with vascular sclerosis, high blood viscosity and poor venous valve function, this lead to a high rate of lower limb DVT when combined with reduced activity postoperatively 13. The influence of malignant tumor and hypertention on DVT was also confirmed by some clinical studies 14-16.…”

Section: Discussionmentioning

confidence: 91%

Risk factors for deep venous thrombosis of lower limbs in postoperative neurosurgical patients

Chen

et al. 2016

Pak J Med Sci

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Objectives:To detect the risk factors for deep venous thrombosis (DVT) in patients after neurosurgery.Methods:Three hundred and seventy-six patients treated in the department of neurosurgery of our hospital from February 2013 to November 2015 were reviewed retrospectively. The clinical data including age, gender, hospital stay, operation time, occupation type, hypertension, coronary heart disease, diabetes, smoking status, drinking status, postoperative exercises, malignant tumor, and postoperative hormone or dehydrating agent were collected.Results:In this study, 52 patients were included in the DVT group and 295 patients in the Non-DVT group. There was significant difference in age, hypertension, occupation type, malignant tumors, operation time, smoking status, and postoperative exercises between the two groups (p<0.05). However, there was no significant difference in gender, drinking status, coronary heart disease, diabetes, hospital stay, and postoperative hormone or dehydrating agent (p>0.05). In multivariate analysis, age, malignant tumor, hypertension were independent risk factors, while physical labour and postoperative exercises were protective factor for DVT.Conclusion:The postoperative patients with older age, malignant tumor or hypertension should be paid high attention to prevent DVT, and postoperative exercises should be selected as precautionary measures.

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Section: Discussionmentioning

confidence: 91%

Risk factors for deep venous thrombosis of lower limbs in postoperative neurosurgical patients

Chen

et al. 2016

Pak J Med Sci

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“…After screening title/abstract and full‐text information, 728 were excluded because of duplicated publications, and 1610 were excluded because the data they provided was not available or unrelated to our topic. Finally, 23 articles that met the inclusion criteria were included in this meta‐analysis . The flow chart of the search strategy is shown in Figure .…”

Section: Resultsmentioning

confidence: 99%

“…All studies reported data on the incidence of VTE . The pooled estimates, using a random‐effect model, indicated that the incidence of VTE in patients who underwent surgery for fractures below the hip was 21% (95%CI: 17%, 24%; P = 0·000) (Figure ).…”

Section: Resultsmentioning

confidence: 99%

Incidence and risk factors for venous thromboembolism following surgical treatment of fractures below the hip: a meta‐analysis

Tan

et al. 2016

International Wound Journal

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Venous thromboembolism (VTE) is a common complication after surgical treatment of fractures, which is associated with significant morbidity and mortality. Identifying the risk factors for VTE is important for preventive strategies to reduce the incidence of VTE. Therefore, we conducted a meta-analysis to evaluate the incidence of VTE and the risk factors influencing the development of VTE in patients who underwent surgery for fractures below the hip. PubMed, Embase, Web of Science, SinoMed (Chinese BioMedical Literature Service System, China) and CNKI (National Knowledge Infrastructure, China) databases were systematically searched to identify cohort or case-control studies that investigated the incidence and risk factors for VTE following surgical treatment of fractures below the hip. VTE risk ratios (RRs) were pooled by use of a fixed-effect model or a random-effect model, depending on the heterogeneity among the included studies. Heterogeneity between the studies was assessed by I statistics. Twenty-three studies with a total of 191 294 patients who met the inclusion criteria were included in this meta-analysis. Our results demonstrated that age (≥60 years) (RR = 1·85, 95% confidence interval (CI): 1·34, 2·55; P = 0·000), previous VTE(RR = 5·25, 95% CI: 2·77, 9·96; P = 0·000), heart failure (RR = 1·74, 95% CI: 1·34, 2·27; P = 0·000), current smoking status (RR = 1·23, 95% CI: 1·07, 1·41; P = 0·004), hypertension (RR = 1·62, 95% CI: 1·27, 2·06; P = 0·000), hyperlipidaemia (RR = 2·16, 95% CI: 1·79, 2·62; P = 0·000), diabetes mellitus (RR = 1·46, 95% CI: 1·27, 1·68; P = 0·000), obesity (RR = 1·58, 95% CI: 1·35,·1·85; P = 0·000), multiple fractures (RR = 2·14, 95% CI: 1·00, 4·60; P = 0·050), varicose veins (RR = 3·07, 95% CI: 1·12, 8·47; P = 0·030), prolonged operation time (weighted mean differences (WMD) = 1·22, 95% CI: 0·63, 1·81; P = 0·000) and prolonged bed rest time (WMD = 3·12, 95% CI: 2·96, 3·29; P = 0·000) were associated with an increased risk of developing VTE. The other variables, including age (<60 years), previous smoking, immobility, pregnancy, cancer, open fractures and combination with trauma were not identified as significant risk factors for VTE. Almost all the risk factors mentioned above are in line with the known risk factors for VTE following surgery for fractures below the hip. Thus, surgeons should pay close attention to patients with these medical conditions in order to reduce the incidence of VTE following surgical treatment of fractures below the hip.

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“…In a study by Kang et al [17] DVT was detected by B-mode ultrasonography performed 7 days after TKR in 175/1025 patents aged >75 years. Diabetes (P = 0.014), high body mass index (BMI) (P = 0.003) and hyperomocysteinemia (P < 0.001) were significantly more frequent in the thrombus group.…”

Section: Pathophysiologymentioning

confidence: 99%

Prophylaxis of Venous Thromboembolism in Knee Replacement Surgery

Rostagno¹,

Carulli²,

Cartei³

et al. 2016

Prog Orthop Sci

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Venous thromboembolism (VTE) is still a frequent and sometimes severe complication after knee replacement surgery. Both pharmacological and non-pharmacological measures have been widely used to decrease VTE risk. Non pharmacological treatment include measures directed to decrease the effects of blood stasis, intermittent pneumatic compression device (IPCD) and graduated compression stockings, and mechanical devices. Pharmacological prophylaxis of venous thromboembolism (VTE) is associated with a more significant decrease in the incidence of deep venous thrombosis (DVT) and related complications after knee arthroplasty however anticoagulation may increase the risk of postoperative bleeding and related complications, in particular the need for re-intervention. Aim of present review was to suggest practical approach to DVT prophylaxis in patients undergoing knee arthroplasty. Although parenteral drugs (low dose unfractionated heparin, low molecular weight heparin and fondaparinux) are the more frequently employed agents, limited compliance may be a concern. Recent studies suggest that direct oral anticoagulants, antithrombin and anti Xa agent, might be a useful alternative although safety may limited by an higher rate of local bleeding.

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Analysis of Risk Factors for Lower-limb Deep Venous Thrombosis in Old Patients after Knee Arthroplasty

Cited by 32 publications

References 24 publications

Risk factors for deep venous thrombosis of lower limbs in postoperative neurosurgical patients

Risk factors for deep venous thrombosis of lower limbs in postoperative neurosurgical patients

Incidence and risk factors for venous thromboembolism following surgical treatment of fractures below the hip: a meta‐analysis

Prophylaxis of Venous Thromboembolism in Knee Replacement Surgery

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