Analysis of Risk Factors for Nonoperative Vertebral Refracture after Vertebroplasty for Single-Segment Vertebral Fracture

Abstract

Objective: To analysis the risk factors of nonsurgical vertebral refracture by making retrospectively study about patients with osteoporotic vertebral compression fractures (OVCF) had accepted vertebroplasty.Methods: From June 2016 to December 2017, there were 161 cases of OVCF patients were treated with single-segment vertebroplasty in our department, and follow-up data including age, gender, bone density, bone cement volume, bone cement puncture route, bone cement leakage and vertebral refracture were collected.T-test and chi-square test were used to analyze the possible risk factors for postoperative vertebral refracture.Results: Among 161 patients treated with vertebroplasty, 19 of them had refracture. Among the refracture group, including 2 males and 17 females,bone density (-3.49 + 0.20) in the refracture group, and bone density (-2.95 + 0.57) in the nonrefracture group.The difference was statistically significant (t=-4.162,P<0.001).Eight patients in the refracture group had cement intervertebral leakage, 11 patients in the nonre-fracture group had cement intervertebral leakage,24 patients in the nonre-fracture group had cement intervertebral leakage, and 138 patients in the nonre-fracture group had cement intervertebral leakage. The difference was statistically significant (chi-square = 6.928,P= 0.008).However, there was no statistically significant difference in age, gender, bone cement content, fracture history, surgical method, surgical site, puncture route and other factors.Conclusions: Decreased bone density and intervertebral leakage of bone cement may be risk factors for postoperative nonoperative vertebral refracture. Therefore, reasonable antiosteoporosis treatment should be adhered to, and intervertebral leakage of bone cement should be minimized, to reduce the occurrence of postoperative refracture.