Analysis of risk factors for abdominal aortic aneurysm in a cohort of more than 3 million individuals

Kent, K. Craig; Zwolak, Robert M.; Egorova, Natalia; Riles, Thomas S.; Manganaro, A; Moskowitz, Alan J.; Gelijns, Annetine C.; Greco, Giampaolo

doi:10.1016/j.jvs.2010.05.090

Cited by 613 publications

(575 citation statements)

References 19 publications

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“…AAA and atherosclerosis share several risk factors, such as male sex, age, smoking and arterial hypertension (Forsdahl et al, 2009). In population -based studies, AAA is independently associated with pre -existing coronary arterial disease (CAD) (Golledge et al, 2006;Kent et al, 2010). The high prevalence of CAD among patients with AAA is well known, with an impact on short term survival after AAA repair (Falk et al, 1997).…”

Section: Introductionmentioning

confidence: 99%

Abdominal Aortic Aneurysm in Patients with Coronary Artery Disease: A Review Article

Elkalioubie¹,

Jude²,

Dupont³

2011

Diagnosis and Treatment of Abdominal and Thoracic Aortic Aneurysms Including the Ascending Aorta and the Aortic Arch

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Section: Introductionmentioning

confidence: 99%

Abdominal Aortic Aneurysm in Patients with Coronary Artery Disease: A Review Article

Elkalioubie¹,

Jude²,

Dupont³

2011

Diagnosis and Treatment of Abdominal and Thoracic Aortic Aneurysms Including the Ascending Aorta and the Aortic Arch

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“…The average concentration of Mg in serum of patients with CA was 21.26 ± 3.10 mg/L and did not differ significantly (p = 0.368) on the content of this element in the serum of healthy people: 20.62 ± 2.06 mg/L - One of the factors that eliminate the development of the aneurysm may be proper diet [6][7][8][9], including adequate supply of mineral components, which are essential factors in numerous metabolic processes functioning as coenzymes or biologically active substances. Mg is absorbed from diet in about 50%, and there are many factors causing the negative balance of this element in the body.…”

Section: Magnesium (Mg)mentioning

confidence: 97%

“…The single available scientific reports from recent years describe the effect of certain dietary factors on the risk of aneurysm, such as eating high-cholesterol, fatty meat, alcohol consumption, inadequate intake of fruits and vegetables and also smoking. According to the authors of these papers it results in an increased incidence of aortic and cerebral aneurysms [6][7][8][9].…”

Section: Introductionmentioning

confidence: 99%

Mineral Components in Aneurysms

Socha¹,

Borawska²

2012

Aneurysm

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We examined 4 groups:1. Patients with AAA (45 men and 5 women) aged 42-81 years, hospitalized at the Department of Vascular Surgery and Transplantology of Medical University of Bialystok, from which blood samples were taken. The samples of aortic wall and parietal thrombus were collected during surgery. The study included patients with an aneurysm diameter of 3.5 -15 cm. In 33% of patients occurred aneurysm rupture, in 37% was inflammatory aneurysm, and in 45% of patients femoral artery aneurysm coexisted; 2. Patients with CA (27 men and 43 women) aged 16 -73 years, hospitalized at the Department of Neurosurgery of Medical University of Bialystok, from which blood samples were taken in the early phase (up to 72 hrs.) after the aneurysmal rupture; Aneurysm 28 3. Healthy people (n = 22), appropriately matched to examined groups by age and gender, from which blood samples were taken -control group; 4. Aortic wall samples (n = 15) without aneurysm, taken from died people aged 39 -79 years -control group.Food-frequency questionnaires were implemented to collect the dietary data. The patients with aneurysms were asked to complete the questionnaire concerning the consumption frequency of food product and smoking by the National Food and Nutrition Institute and the National Cardiology Institute [10]. 28 patients with CA, due to poor health were disclosed from nutritional information collecting. The list of food commodities consisted of 36 food items (white bread, wholegrain bread,

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“…Chronic tobacco smoking has been identified as the most important risk factor for AAA (4,5). In addition to smoking, inherited susceptibility to AAA has also been identified as a critical causative factor accounting for this disease (6).…”

Section: Introductionmentioning

confidence: 99%

A comprehensive analysis of differentially expressed genes and pathways in abdominal aortic aneurysm

Yuan

Liang

Zhang

2015

Molecular Medicine Reports

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Abstract. The current study aimed to investigate the molecular mechanism underlying abdominal aortic aneurysm (AAA) via various bioinformatics techniques. Gene expression profiling analysis of differentially expressed genes (DEGs) between AAA samples and normal controls was conducted. The Database for Annotation, Visualization and Integrated Discovery tool was utilized to perform Gene ontology (GO) and Kyoto Encyclopedia of Genes and Genomes analyses for DEGs and clusters from the protein-protein interaction (PPI) network, which was constructed using the Search Tool for the Retrieval of Interacting Genes. In addition, important transcription factors (TFs) that regulated DEGs were investigated. A total of 346 DEGs were identified between AAA samples and healthy controls. Additionally, four clusters were identified from the PPI network. Cluster 1 was associated with sensory perception of smell and the olfactory transduction subpathway. The most significant GO function terms for cluster 2 and 3 were response to virus and defense response, respectively. Cluster 4 was associated with mitochondria-associated functions and the oxidative phosphorylation subpathway. Early growth response-1 (EGR-1), Myc, activating transcription factor 5 (ATF5) and specificity protein (SP) 1:SP3 were identified to be critical TFs in this disease. The present study suggested that the olfactory transduction subpathway, mitochondria and oxidative phosphorylation pathways were involved in AAA, and TFs, such as EGR-1, Myc, ATF5 and SP1:SP3, may be potential candidate molecular targets for this disease.

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Analysis of risk factors for abdominal aortic aneurysm in a cohort of more than 3 million individuals

Cited by 613 publications

References 19 publications

Abdominal Aortic Aneurysm in Patients with Coronary Artery Disease: A Review Article

Abdominal Aortic Aneurysm in Patients with Coronary Artery Disease: A Review Article

Mineral Components in Aneurysms

A comprehensive analysis of differentially expressed genes and pathways in abdominal aortic aneurysm

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