Analysis of Risk Factors of Predictive Local Tumor Control in Oral Cavity Cancer

Liao, Chun‐Ta; Chang, Joseph Tung-Chieh; Wang, Hung‐Ming; Ng, Shu‐Hang; Hsueh, Chuen; Lee, Li‐Yu; Lin, Chih‐Hung; Chen, I-How; Huang, Shiang‐Fu; Cheng, Ann‐Joy; Yen, Tzu‐Chen

doi:10.1245/s10434-007-9761-5

Cited by 255 publications

(203 citation statements)

References 26 publications

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“…Presence of cervical lymph node metastasis, location of the tumor and its size are the most important prognostic factors in the patients with head and neck squamous cell carcinoma (SCC) (1,2). Routine staging method for preoperative detection of cervical lymph node metastasis in the patients with oral cavity SCC comprised of physical examination and computed tomography (CT)/ magnetic resonance imaging (MRI) (3,4). Positron emission tomography (PET) imaging also took its place in this evaluation by the recent technological developments.…”

Section: Introductionmentioning

confidence: 99%

The Role of PET-CT in Evaluation of Cervical Lymph Node Metastases in Oral Cavity Squamous Cell Carcinomas

Çaylaklı

Yılmaz

Özer

et al. 2015

Turk Arch Otorhinolaryngol

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Objective: The aim of this study is to determine the sensitivity and specificity of positron emission tomography-computed tomography (PET-CT) in the evaluation of cervical lymph node metastasis in oral cavity squamous cell cancers (SCCs) and to determine the SUV-max values in differentiating reactive and metastatic lymph nodes as a supportive parameter. Methods:In this study, 23 patients were included who were diagnosed with oral cavity SCC and treated with surgery between 2006 and 2013 in our department. All the patients were scanned with PET-CT during the pretreatment evaluation. Detailed pretreatment PET-CT (retention sites and SUV-max values) and histopathological examination results were obtained. SPSS 17.0 software package was used for statistical analysis of the data. Categorical measurement was summarized as number and percentage and continuous measurements as mean and standard deviation (median and minimum-maximum where necessary). Chi-square test or Fisher's test were used in the comparison of categorical variables. Compliance of methods was assessed by Kappa coefficient analysis. In this study, the advantages of PET-CT were determined by the calculation of sensitivity and specificity values with histopathological examination results considered as the gold standard, and SUV-max value was assessed by examining the area under the ROC curve. In all tests, the level of statistical significance was accepted as 0.05. Results:The threshold value for SUV-max depending on the data of the histopathological examination and results of PET-CT of the 23 patients was 2.50. The reliability of this threshold was determined as AUC=0.819. In demonstrating neck metastasis in patients with cancer of the oral cavity, PET-CT has a sensitivity of 89% and specificity of 98%. Compliance between the histopathological examination and PET-CT for metastatic cervical lymph nodes was determined to be 0.416 by kappa coefficient analysis. Conclusion:There was FDG uptake on PET-CT in the cervical lymph node regions of all patients with metastatic cervical lymph nodes. There were no metastases in any of the patients with no FDG retention. The sensitivity and specificity of PET-CT in determining cervical lymph node metastasis were 89% and 98%, respectively, with a threshold SUV-max value considered as 2.50 in patients with FDG retention. Keywords

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Section: Introductionmentioning

confidence: 99%

The Role of PET-CT in Evaluation of Cervical Lymph Node Metastases in Oral Cavity Squamous Cell Carcinomas

Çaylaklı

Yılmaz

Özer

et al. 2015

Turk Arch Otorhinolaryngol

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“…In particular, its local recurrence is strongly related to a poor prognosis (4)(5)(6). Even when the surgical margins are diagnosed as tumor free by histopathological examination, the local recurrence rate is still 6.9-22.0% (4,5,7,8). There are two explanations for the mechanism of local recurrence (9).…”

Section: Introductionmentioning

confidence: 99%

Expression of the cancer stem cell markers CD44v6 and ABCG2 in tongue cancer: Effect of neoadjuvant chemotherapy on local recurrence

Yanamoto

Yamada

Takahashi

et al. 2014

International Journal of Oncology

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Abstract. The efficacy of neoadjuvant chemotherapy (NAC) is controversial, and no report supports NAC with a high evidence level. Recently, we showed that a deep surgical margin was resected very close to the tumor site in many NAC-treated oral squamous cell carcinoma patients, suggesting that NAC may lead to local recurrence and poor outcomes. The purpose of this study was to evaluate the effect of NAC on tumor local recurrence using cancer stem cell marker immunohistochemistry. We retrospectively analyzed 89 patients who underwent radical surgery for tongue cancer, and examined the effect of NAC on tumor local recurrence. Cancer stem cell marker (CD44v6 and ABCG2) expression was detected by immunohistochemistry. In our study, the local recurrence rate was 12.4%. CD44v6 and ABCG2 expression was significantly associated with regional lymph node metastasis, pattern of invasion, depth of invasion, perineural invasion and local recurrence, respectively. Tumor local recurrence was a significant independent predictive factor of the 5-year disease specific survival. CD44v6 or ABCG2 positivity in NAC-treated patients was significantly associated with tumor local recurrence. It was suggested that local recurrence in NAC-treated cases is associated with cancer stem-like cells. We propose that NAC leads to the selection and/or residue of more aggressive cancer stem-like cells.

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“…Over the past 2 decades, the overall incidence and morbidity rates of patients with oral cancer have increased continuously. Epidemiological studies show that ϳ50 -70% of patients who undergo surgery for oral cancer die within 5 years (1)(2)(3)(4)(5)(6). This poor prognosis predominantly reflects late stage presentation, secondary cancer occurrence, local recurrence, and metastasis (7) as well as the lack of suitable markers for cancer detection.…”

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confidence: 99%

Enhanced Interferon Signaling Pathway in Oral Cancer Revealed by Quantitative Proteome Analysis of Microdissected Specimens Using 16O/18O Labeling and Integrated Two-dimensional LC-ESI-MALDI Tandem MS

Chi

Lee

Chang

et al. 2009

Molecular & Cellular Proteomics

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Analysis of Risk Factors of Predictive Local Tumor Control in Oral Cavity Cancer

Abstract: Taken together, our data suggest that pathological margins and pathological tumor depth are major independent prognosticators not only for local tumor control, but also for DSS and OS.

Cited by 255 publications

References 26 publications

The Role of PET-CT in Evaluation of Cervical Lymph Node Metastases in Oral Cavity Squamous Cell Carcinomas

The Role of PET-CT in Evaluation of Cervical Lymph Node Metastases in Oral Cavity Squamous Cell Carcinomas

Expression of the cancer stem cell markers CD44v6 and ABCG2 in tongue cancer: Effect of neoadjuvant chemotherapy on local recurrence

Enhanced Interferon Signaling Pathway in Oral Cancer Revealed by Quantitative Proteome Analysis of Microdissected Specimens Using 16O/18O Labeling and Integrated Two-dimensional LC-ESI-MALDI Tandem MS

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