Analysis of risk factors of neonatal hypoglycemia and its correlation with blood glucose control of gestational diabetes mellitus: A retrospective study

Cao, Yu; Yang, Yun; Liu, Lei; Ma, Juan

doi:10.1097/md.0000000000034619

Cited by 4 publications

(1 citation statement)

References 18 publications

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“…Neonatal hypoglycemia is essentially the inability to adapt to extrauterine physiology. It results from an imbalance between glucose supply and utilization due to immature regulatory mechanisms [6]. In a New Zealand study, approximately 50% of infants developed hypoglycemia, with 19% experiencing severe episodes and the same percentage having multiple episodes.…”

Section: Introductionmentioning

confidence: 99%

The Frequency of Hypoglycemia and Its Symptoms in Preterm Neonates in the First 24 Hours

Khan,

Muhammad Safwan,

Shad

et al. 2024

Cureus

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Introduction Hypoglycemia is a critical concern in neonatal care, particularly among preterm infants. This study aims to investigate the frequency of hypoglycemia within the first 24 hours of life in preterm neonates, considering factors such as gestational age (GA), birth weight, and gender. Materials and methods A cross-sectional study was conducted from February to August 2021. The sample comprised 186 preterm infants selected through consecutive sampling. Data collection involved demographic information, glucose level monitoring, and symptom assessment. Results Of the 186 preterm neonates, 31.7% (n=59) experienced hypoglycemia within the first 24 hours, with feeding refusal being the predominant symptom. There was a significant difference in hypoglycemia occurrence between infants born before and after 32 weeks of gestation (p<0.05). Males were slightly more affected than females, although not statistically significant. Infants weighing less than 2 kg showed a higher susceptibility to hypoglycemia. Conclusion The early detection and management of hypoglycemia are crucial in preterm neonatal care. Close monitoring, especially in the initial four hours, is essential to prevent complications. Larger studies are warranted to confirm these findings and improve understanding and management strategies for hypoglycemia in preterm neonates, particularly within the first 24 hours of life.

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Section: Introductionmentioning

confidence: 99%

The Frequency of Hypoglycemia and Its Symptoms in Preterm Neonates in the First 24 Hours

Khan,

Muhammad Safwan,

Shad

et al. 2024

Cureus

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Influencing factors of glycemic control in singleton pregnancies complicated by gestational diabetes mellitus in western China: A retrospective study

Zhang,

Mao,

Cao

et al. 2024

Medicine

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To investigate the factors influencing glycemic control in gestational diabetes mellitus (GDM) patients and their impacts on pregnancy outcomes, providing insights for GDM management. Pregnant women diagnosed with GDM at a tertiary hospital in western China in 2019. Participants were categorized based on varying levels of glycemic control during pregnancy. A retrospective analysis was conducted, utilizing univariate and multivariate regression analyses, to identify factors influencing glycemic control in GDM patients. Based on various approaches to manage glucose, subjects were categorized into A1 (diet and exercise guidance alone) and A2 (insulin usage) groups. Based on whether glucose levels met the glycemic target in women with GDM, subjects were further divided into satisfactory and unsatisfactory groups. A total of 2621 women meeting the inclusion criteria were enrolled in the study. Independent factors associated with GDM A2 included higher prepregnancy body mass index (odds ratio [OR] = 1.070, 95% confidence interval [CI]: 1.019–1.122, P = .006), a history of GDM (OR = 1.888, 95% CI: 1.052–3.389, P = .033), elevated fasting plasma glucose (FPG) in early pregnancy (OR = 1.828, 95% CI: 1.320–2.532, P < .001), elevated 1-hour postprandial glucose (1-h PG) (OR = 1.126, 95% CI: 1.0091.256, P = .034), and 2-h PG by oral glucose tolerance test (OGTT) (OR = 1.181, 95% CI: 1.046–1.333, P = .007). Higher FPG by OGTT was an independent risk factor for unsatisfactory glycemic control (OR = 1.590, 95% CI: 1.273–1.985, P < .001). Compared with the A1 group, the A2 group has longer hospitalization, higher rates of cesarean section, placenta previa, and neonatal pneumonia (P < .05). Compared with the satisfactory group, the unsatisfactory group has lower gestational age, lower rates of cesarean section and placenta previa, and higher rates of postpartum hemorrhage for mothers; lower length and weight, and higher rates of premature birth, jaundice, hypoglycemia, pneumonia, respiratory distress syndrome, anemia, hospitalization, and hospitalization for more than 15 days in both pediatric unit and neonatal intensive care unit for newborns (P < .05). Elevated prepregnancy body mass index, FPG in early pregnancy, 1-h and 2-h PG during OGTT, and with a history with GDM are independent factors influencing insulin utilization, while elevated 0-h PG is an independent influencing factor of unsatisfactory glycemic control. Poor glycemic control has negative impacts on both maternal and fetal outcomes under 2 classifications.

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A Prospective Randomized Study of the Potential Biomarker miR-204-5p for the Differential Diagnosis of Gestational Diabetes Mellitus and its Correlation with Pregnancy Outcomes

Shi,

Ding

2024

Clin. Exp. Obstet. Gynecol.

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Background: Gestational diabetes mellitus (GDM) is a common complication of pregnancy that has a certain impact on maternal and infant health. The aim of this study was to investigate the diagnostic value of microRNA-204-5p (miR-204-5p) in GDM by analyzing its differential expression between GDM patients and healthy individuals and to assess its predictive potential for the occurrence of poor maternal and infant outcomes in GDM patients. Methods: GDM patients (107; GDM group) and healthy pregnant women (92; control group) were recruited for this prospective study. GDM patients meet the relevant criteria of the International Association of Diabetes and Pregnancy Study Groups (IADPSG), which are categorized into good and poor outcome groups on the basis of maternal and infant pregnancy outcomes. Serum miR-204-5p expression was quantified via the reverse transcription quantitative polymerase chain reaction (RT-qPCR). The diagnostic potential of miR-204-5p in GDM patients was analyzed by receiver operating characteristic (ROC) curves and further assessed for its ability to predict the occurrence of poor maternal and infant outcomes in GDM patients. The difference in clinical indicators between GDM patients and healthy pregnant women was determined through Student's t-test, and the clinical indicators of GDM patients in the good outcome group and the poor outcome group were evaluated. The potential of miR-204-5p as a risk factor for poor maternal and infant outcomes in GDM patients was evaluated by binary logistic analysis. Results: miR-204-5p expression was decreased in GDM patients compared to healthy pregnant women. The area under the curve (AUC) for distinguishing the healthy people from GDM patients was 0.918, with a sensitivity and specificity of 78.5% and 90.2%. Additionally, miR-204-5p expression in GDM patients in the poor outcome group was lower than that in the good outcome group. The AUC reflecting the potential of miR-204-5p in predicting poor maternal and infant outcomes in GDM patients was 0.855, with a sensitivity of 66.7% and a specificity of 90.5%. miR-204-5p is a risk factor for poor maternal and infant outcomes in GDM patients. Conclusions: Serum miR-204-5p expression is low in GDM and has a high diagnostic potential for predicting the occurrence of GDM and poor maternal and infant pregnancy outcomes. It is expected to be a biomarker for the risk of GDM.

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Analysis of risk factors of neonatal hypoglycemia and its correlation with blood glucose control of gestational diabetes mellitus: A retrospective study

Cited by 4 publications

References 18 publications

The Frequency of Hypoglycemia and Its Symptoms in Preterm Neonates in the First 24 Hours

The Frequency of Hypoglycemia and Its Symptoms in Preterm Neonates in the First 24 Hours

Influencing factors of glycemic control in singleton pregnancies complicated by gestational diabetes mellitus in western China: A retrospective study

A Prospective Randomized Study of the Potential Biomarker miR-204-5p for the Differential Diagnosis of Gestational Diabetes Mellitus and its Correlation with Pregnancy Outcomes

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