The design and implementation of a multi-stage PID (MS-PID) controller for non-inertial referenced UAVs are highly complex. Symmetrical multirotor UAVs are unstable systems, and it is thought that the kinematics of the symmetrical UAV rotor, such as the quadrotor and hexacopter resembles the kinematics of an inverted pendulum. Several researchers have investigated the structure and design of PID controllers for high-order systems during the last decade. The designs were always concerned with the enhanced response, robustness, model reduction and performance of PID controllers. An accurate tuning process of such a controller depends on the engineer’s experience level. This is due to the number of variables and hyperparameters tuned during the process. An adaptive genetic algorithm (AGA) is utilized to optimize the MS-PID controllers for controlling the quadrotor in this study. The proposed method optimizes the offline-planned approach, providing several possibilities for adapting the controllers with various paths and or varying weather conditions. The MS-PID parameters are optimized in parallel, as every PID controller affects the other controller’s behavior and performance. Furthermore, the proposed AGA generates new chromosomes for “new solutions” by randomly developing new solutions close to the previous best values, which will prevent any local minima solution. This study intends to investigate the design and development of a highly tuned robust multi-stage PID controller for a symmetrical multirotor UAV. The work presents a model for a non-referenced inertial frame multirotor UAV (quadcopter). Once the model is defined, a robust multi-stage PID controller for the non-inertial referenced frame symmetrical multirotor UAV is designed, tuned, and tested. A genetic algorithm (GA) will be used to tune the MS-PID controller. Finally, the performance comparison between the proposed and conventional methods is presented. The results show that the proposed method provides stability improvement, better transient response, and power consumption.