Analysis of Salicylamide and Its Metabolites in Blood and Urine by HPLC

Fielding, Robert M.; Waschek, James A.; Rubin, Gerald M.; Pond, Susan M.; Tozer, Thomas N.

doi:10.1080/01483918408074039

Journal of Liquid Chromatography

1984

DOI: 10.1080/01483918408074039

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Analysis of Salicylamide and Its Metabolites in Blood and Urine by HPLC

Robert M. Fielding

James A. Waschek

Gerald M. Rubin

et al.

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Cited by 9 publications

References 13 publications

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Recrystallization of Salicylamide using a Batch Supercritical Antisolvent Process

Su¹,

Chen²

2005

Chem. Eng. Technol.

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Recrystallization of the nonsteroidal anti-inflammatory drug salicylamide was investigated using a batch supercritical antisolvent (SAS) precipitation process. Carbon dioxide was used as the antisolvent, and acetone, ethanol and ethyl acetate were used as solvents. Particle morphology determined by SEM showed that particles with a regular shape were obtained from the SAS process. The crystal structure analyzed by XRD showed that the intensities of specific peaks were modified. No decomposition or deterioration was confirmed by DSC measurements where the melting temperature remained the same after SAS recrystallization. The effects of process parameters were investigated with acetone as the solvent. At a higher pressure of 110 bar, a higher saturation concentration of 90 %, and a lower temperature of 293 K, the length of the rectangular particles decreased to 50 lm. This showed a significant change from the irregular and broken particle shapes with particle sizes up to 200 lm before processing by SAS.

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Recrystallization of Salicylamide using a Batch Supercritical Antisolvent Process

Su¹,

Chen²

2005

Chem. Eng. Technol.

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3-Hydroxylation of Salicylamide in Mice

Howell

Kotkoskie

Dills

et al. 1988

Journal of Pharmaceutical Sciences

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Time-dependent, plasma-sulfate-independent kinetics of salicylamide in dogs

Waschek

Fielding

Tozer

et al. 1988

Journal of Pharmacokinetics and Biopharmaceutics

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The mechanisms of the dose-dependent elimination kinetics of salicylamide in dogs were examined. Salicylamide was infused continuously over three consecutive 90-min periods. The rates of infusion during Periods I and III were the same. During Period II the infusion rate was 2.5-fold higher. Plasma concentrations of inorganic sulfate were kept constant by the administration of exogenous sulfate. The plasma concentrations of salicylamide, which reached steady state during Period I but not during II or III, were twice as high at the end of Period III than those at the end of Period I. Typical Michaelis-Menten kinetics do not explain these results. When salicylamide was given as 40 mg/kg single oral dose, clearance of an intravenous tracer dose of radiolabeled salicylamide was greatly reduced within 10 min but returned to baseline values by 240 min after the oral dose, despite persistently low plasma concentrations of inorganic sulfate. Therefore, dose- and time-dependent factors other than Michaelis-Menten kinetics, depletion of inorganic sulfate concentrations, and rate limitation of supply of "active sulfate" from plasma inorganic sulfate stores produce the dose- and time-dependent kinetics of salicylamide in the dog. Product inhibition of salicylamide sulfoconjugation remains a possible explanation.

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Analysis of Salicylamide and Its Metabolites in Blood and Urine by HPLC

Cited by 9 publications

References 13 publications

Recrystallization of Salicylamide using a Batch Supercritical Antisolvent Process

Recrystallization of Salicylamide using a Batch Supercritical Antisolvent Process

3-Hydroxylation of Salicylamide in Mice

Time-dependent, plasma-sulfate-independent kinetics of salicylamide in dogs

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