Analysis of saponins of wild Panax ginseng.

Yamaguchi, Hiroyuki; Matsuura, Hiromichi; Kasai, Ryouji; Tanaka, Osamu; Satake, Motoyoshi; Kohda, Hiroshi; Izumi, Hiromasa; Nuno, Mariko; Katsuki, Shigeki; Isoda, Susumu; Shoji, Jun; Goto, Katsumi

doi:10.1248/cpb.36.4177

Cited by 32 publications

(15 citation statements)

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“…Recoveries of 92-116% were obtained, with RSD values lower than 15% ( Table 3). As described above, our data demonstrated that the analytical method was suitable for the quantitative analysis of seven saponins (1)(2)(3)(4)(5)(6)(7) in the roots of C. lanceolata. Table 4 shows the contents of saponins 1-7 in the roots of C. lanceolata collected from Korea and Japan.…”

Section: Resultssupporting

confidence: 63%

“…In summary, we developed a simple, rapid, and precise liquid chromatography-mass spectrometry (LC-MS) method for simultaneous determination of seven 3,28-bidesmosidic triterpenoid saponins (1)(2)(3)(4)(5)(6)(7) in the roots of C. lanceolata. The method was validated with respect to linearity, detection limit, precision, and accuracy.…”

Section: Resultsmentioning

confidence: 99%

“…These saponins, shown in Fig. 1, are lancemaside A (1), lancemaside B (2), lancemaside C (3), lancemaside E (4), lancemaside G (5), foetidissimoside A (6), and aster saponin Hb (7). Compound 1 contributes to the recovery of decreased testosterone levels in blood [1].…”

Section: Introductionmentioning

confidence: 99%

“…The chromatographic detection of saponins has been conducted at shorter UV wavelengths, e.g., 202 nm for detection of saponins in Panax ginseng roots [5,6] and 210 nm for detection of saponins in Platycodon grandiflorum A. De Candolle roots [7].…”

Section: Introductionmentioning

confidence: 99%

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Simultaneous determination of seven saponins in the roots of Codonopsis lanceolata by liquid chromatography–mass spectrometry

et al. 2008

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We developed a rapid and simple analytical method for the simultaneous determination of seven 3,28-bidesmosidic triterpenoid saponins in the roots of Codonopsis lanceolata. The saponins are lancemaside A, lancemaside B, lancemaside C, lancemaside E, lancemaside G, foetidissimoside A, and aster saponin Hb. Root samples were extracted with 50% methanol and prepared for analysis. Saponins were detected by reversed-phase high-performance liquid chromatography with electrospray ionization mass spectrometry, and ginsenoside Rb(1) was used as an internal standard. The overall recoveries of all saponins were 92-116%, and the relative standard deviation values of intra- and inter-day precision were lower than 3.7 and 7.7%, respectively. Eight root samples collected from Korea and Japan were analyzed using the developed method. Lancemaside A was the most abundant saponin in the root samples from Korea, ranging from 2.65 to 3.64 mg/g dry root. However, the maximum content of lancemaside A among Japanese samples was 0.101 mg/g dry root.

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Section: Resultssupporting

confidence: 63%

Section: Resultsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Simultaneous determination of seven saponins in the roots of Codonopsis lanceolata by liquid chromatography–mass spectrometry

et al. 2008

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“…Ginsenosides can be classified as neutral and acidic saponins. Major neutral saponins of Radix Ginseng are ginsenosides Rg 1 , Re, Rf, Rb 1 , Rb 2 , Rc, and Rd; the acidic ginsenosides include four malonyl derivatives of the ginsenosides Rb 1 , Rb 2 , Rc, and Rd and ginsenoside R 0 (Kitagawa et al, 1983;Yamaguchi et al, 1988). The acidic ginsenosides were reported to represent 35-60% of the total saponins in Radix Ginseng (Chuang et al, 1995).…”

Section: Introductionmentioning

confidence: 99%

The retention behavior of ginsenosides in HPLC and its application to quality assessment of radix ginseng

Luo

Wang

et al. 2008

Arch. Pharm. Res.

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This study systematically investigated the retention behavior of seven neutral ginsenosides Rg(1), Re, Rf, Rb(1), Rb(2), Rc, Rd, and an acidic ginsenoside R(0), the major pharmacologically active components of Radix Ginseng with RP-HPLC. The effects of solvent, pH value, ionic strength of the mobile phase, and column temperature were investigated using an octadecylsiloxane-bonded silica gel column. Based on the ginsenosides' retention characteristics, the concentration of acetonitrile and the gradient of the mobile phase needed to maintain the baseline separation of the major neutral ginsenosides in Radix Ginseng were theoretically predicted. Furthermore, the ionic strength of mobile-phase necessary to achieve good resolution of the neutral ginsenosides and acidic ginsenosides was carefully investigated. According to the results of the quantitative analysis of ginsenosides in eight batches of ginseng samples from different sources, the developed HPLC technique may be a valuable tool for the quality assessment of Radix Ginseng.

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Saponins

Schwarz¹

2000

Ullmann's Encyclopedia of Industrial Chemistry

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The article contains sections titled: 1. Introduction 1.1. General Properties 1.2. Distribution 1.3. Isolation 1.4. Structure Elucidation 1.5. Analysis 2. Pharmacology 3. Plant Saponins 3.1. Steroid Saponins 3.2. Glycoalkaloids 3.3. Triterpene Saponins 4. Animal Saponins 4.1. Asterosaponins 4.2. Holothurins

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Analysis of saponins of wild Panax ginseng.

Abstract: The composition and contents of neutral and acidic saponins of Chinese and Japanese wild

Cited by 32 publications

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Simultaneous determination of seven saponins in the roots of Codonopsis lanceolata by liquid chromatography–mass spectrometry

Simultaneous determination of seven saponins in the roots of Codonopsis lanceolata by liquid chromatography–mass spectrometry

The retention behavior of ginsenosides in HPLC and its application to quality assessment of radix ginseng

Saponins

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