Analysis of Serum Adiponectin, Resistin and Leptin Levels in Children and Adolescents with Autoimmune Thyroid Disorders

Bossowski, Artur; Sawicka, Beata; Szalecki, Mieczysław; Koput, Alicja; Wysocka, Jolanta; Żelazowska-Rutkowska, Beata

doi:10.1515/jpem.2010.058

Cited by 24 publications

(15 citation statements)

References 26 publications

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“…The results of our study showed that serum resistin level was significantly decreased in untreated GD patients compared with healthy controls, which is in accordance with Iglesias and Bossowski A's study [24, 25]. But conflict with Iglesias study which exhibited resistin level had no change after treatment, our study found the resistin level increased to normal range when the patients returned to a euthyroid state.…”

Section: Discussionsupporting

confidence: 90%

“…Similar to the result above, Bossowski A et al . also found a reduction of serum resistin in GD patients compared with simple goiter and Hashimoto's thyroiditis patients [25]. There were also several studies demonstrating that resistin is up-regulated in hyperthyroidism patients and returned to normal range after normalizing thyroid hormones [26, 27].…”

Section: Introductionmentioning

confidence: 99%

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Down-regulated resistin level in consequence of decreased neutrophil counts in untreated Grave's disease

Peng

Huang

et al. 2016

Oncotarget

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Resistin, belongs to cysteine-rich secretory protein, is mainly produced by circulating leukocytes, such as neutrophils monocytes and macrophages in humans. To date, few but controversial studies have reported about resistin concentrations in hyperthyroid patients, especially in Graves' disease (GD). We undertaked a controlled, prospective study to explore the serum resistin concentration in GD patients before and after -MMI treatment. In addition, we also investigated the main influencing factor on serum resistin level and discuessed the potential role of serum resistin plays in GD patients. 39 untreated GD (uGD) patients, including 8 males and 31 females, were enrolled in our investigation. All of these patients were prescribed with MMI treatment, in addition to 25 healthy controls. Anthropometric parameters and hormone assessment were measured. Enzyme-linked immunosorbent assay was used to detect serum resistin concentration in different stages of GD patients. Furthermore, neutrophil cell line NB4 with or without T3 treatment to detect the effect of thyroid hormones on resistin expression. The serum resistin level and neutrophil counts in untreated GD patients were significantly declined. And all of these parameters were recovered to normal after MMI treatment in ethyroid GD (eGD) and TRAb-negative conversion (nGD) patients. Resistin concentration exhibited a negative correlation with FT3 and FT4, but a positive correlation with absolute number of neutrophiles in uGD patients, whereas did not correlate with thyroid autoimmune antibodies and BMI. Neutrophile cell line, NB4, produced decreased expression of resistin when stimulated with T3. Our study showed a decrease of serum resistin level in GD patients and we suggested that the serum resistin might primarily secreted from circulating neutrophils and down-regulated by excessive thyroid hormones in GD patients.

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Section: Discussionsupporting

confidence: 90%

Section: Introductionmentioning

confidence: 99%

Down-regulated resistin level in consequence of decreased neutrophil counts in untreated Grave's disease

Peng

Huang

et al. 2016

Oncotarget

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“…Some studies found that thyroid hormones exert a negative influence on serum leptin levels in rats (Escobar-Morreale et al 1997;Luvizotto et al 2011), while others showed that administration of physiologic levels of triiodothyronine increased leptin expression in calorie-restricted obese rats (Luvizotto et al 2010). In addition, Sesmilo et al (1998) and Bossowski et al (2010) argue that there was no correlation between serum leptin and thyroid hormone levels. It can be inferred that the regulation of T3 on the expression and secretion of leptin may be tissue dependent and rely on physiologic status (Cabanelas et al 2010).…”

Section: Discussionmentioning

confidence: 99%

Effects of glucose, insulin and triiodothyroxine on leptin and leptin receptor expression and the effects of leptin on activities of enzymes related to glucose metabolism in grass carp (Ctenopharyngodon idella) hepatocytes

Zhou

Yuan

et al. 2015

Fish Physiol Biochem

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Leptin is an important regulator of appetite and energy expenditure in mammals, but its role in fish metabolism control is poorly understood. Our previous studies demonstrated that leptin has an effect on the regulation of food intake and energy expenditure as well as lipid metabolism (stimulation of lipolysis and inhibition of adipogenesis) in the grass carp Ctenopharyngodon idella. To further investigate the role of leptin in fish, the effects of glucose, insulin and triiodothyroxine (T3) on the expression levels of leptin and leptin receptor (Lepr) and the effects of leptin on the activities of critical glucose metabolism enzymes in grass carp hepatocytes were evaluated in the present study. Our data indicated that leptin gene expression was induced by glucose in a dose-dependent manner, while Lepr gene expression exhibited a biphasic change. A high dose of insulin (100 ng/mL) significantly up-regulated the expression of leptin and Lepr. Leptin expression was markedly up-regulated by a low concentration of T3 but inhibited by a high concentration of T3. T3 up-regulated Lepr expression in a dose-dependent manner. Together, these data suggest that leptin had a close relationship with three factors (glucose, insulin and T3) and might participate in the regulation of glucose metabolism in grass carp. In addition, we also found that leptin affected the activities of key enzymes that are involved in glucose metabolism, which might be mediated by insulin receptor substrate-phosphoinositol 3-kinase signaling.

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“…Low-normal thyroid function conveys changes in high density lipoprotein (HDL) anti-oxidative function as well, which conceivably contribute to impaired oxidative stress defense [12]. Interestingly, thyroid function status affects circulating levels of leptin and adiponectin, adipokines which exert pro- and anti-atherogenic properties, respectively [13–15]. Thus, leptin has been reported to decrease and adiponectin to increase after levothyroxine supplementation in subclinical hypothyroidism [16].…”

Section: Introductionmentioning

confidence: 99%

Increased leptin/adiponectin ratio relates to low-normal thyroid function in metabolic syndrome

Tienhoven-Wind

Dullaart

2017

Lipids Health Dis

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BackgroundLow-normal thyroid function within the euthyroid range may contribute to increased atherosclerosis susceptibility. The leptin/adiponectin (L/A) ratio is associated with cardiovascular disease and reflects adipose tissue dysfunction. Relationships of the L/A ratio with low-normal thyroid function are unknown.MethodsRelationships of thyroid stimulating hormone (TSH) and free thyroxine (free T4) with leptin, adiponectin and the L/A ratio in euthyroid subjects were documented in 67 fasting subjects with metabolic syndrome (Mets) and 86 euthyroid subjects without MetS (TSH and free T4 levels within the institutional reference range).ResultsNeither plasma leptin nor adiponectin was significantly correlated with TSH or free T4 in subjects with and without MetS. In the whole group, high sensitivity C-reactive protein (hs-CRP) was positively correlated with the L/A ratio (r = 0.485, P < 0.001). Notably, the L/A ratio was positively correlated with TSH in subjects with MetS (r = 0.252, P = 0.040) but not in subjects without MetS (r = −0.068, P = 0.54; interaction term, P = 0.027). In MetS subjects, the L/A ratio remained positively related with TSH after adjustment for age, sex, diabetes status, hs-CRP and the use of antihypertensive and glucose lowering medication (β = 0.283, P = 0.018), as well as after adjustment for individual MetS components (β = 0.294, P = 0.020).ConclusionsIn the context of MetS, a higher TSH within the euthyroid range confers an increased L/A ratio, a proposed marker of atherosclerosis susceptibility and adipocyte dysfunction.

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Analysis of Serum Adiponectin, Resistin and Leptin Levels in Children and Adolescents with Autoimmune Thyroid Disorders

Cited by 24 publications

References 26 publications

Down-regulated resistin level in consequence of decreased neutrophil counts in untreated Grave's disease

Down-regulated resistin level in consequence of decreased neutrophil counts in untreated Grave's disease

Effects of glucose, insulin and triiodothyroxine on leptin and leptin receptor expression and the effects of leptin on activities of enzymes related to glucose metabolism in grass carp (Ctenopharyngodon idella) hepatocytes

Increased leptin/adiponectin ratio relates to low-normal thyroid function in metabolic syndrome

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