Analysis of serum insulin-like growth factor-1, fibroblast growth factor 23, and Klotho levels in girls with rapidly progressive central precocious puberty

Abstract

To study the levels of serum insulin-like growth factor 1 (IGF-1), fibroblast growth factor 23 (FGF23), and Klotho, and to study their relationship with girls with rapidly progressive central precocious puberty (RP-CPP). This is a cross-sectional study on the progression rate of central precocious puberty in girls, who complained of breast development before the age of 8 years and were followed between June 2021 and June 2022. At the same time, 28 healthy girls less than 8 years old who had not started puberty were recruited as the control group. The physical examination and laboratory evaluation of each group was completed. Only patients with CPP received pelvic ultrasound examination and bone age test. Bone age index (BAI), basal LH levels (BLH), basal LH levels/basal FSH levels (BFSH), peak LH (PLH)/peak FSH (PFSH), IGF-1, Klotho, FGF23, and ovarian volume in the RP-CPP group were higher than those in slowly progressive CPP (SP-CPP) group. In the RP-CPP group, IGF-1 was correlated with Klotho, FGF23, and BLH; Klotho was correlated with FGF23 and BLH; FGF23 was correlated with BLH.Conclusion: The BLH, FGF23, Klotho, and IGF-1 have a certain correlation with RP-CPP, which may play an important role in the speed of girls’ sexual development. What is Known:• The association between IGF-1 and RP-CPP. What is New:• We found the association between FGF23, Klotho and RP-CPP.

α-Klotho levels in girls with central precocious puberty: potential as a diagnostic and monitoring marker

“…In addition, our multivariable logistic regression analysis for CPP revealed that α-Klotho is a significant factor influencing the outcome, similar to basal LH and estradiol. Furthermore, a previous study demonstrated the correlation between basal LH, FGF23, Klotho, and IGF-1 with rapidly progressive CPP, suggesting their potential importance in the rate of sexual development in girls ( 24 ). Building upon this body of literature and our own results, we hypothesized that an increase in LH, FSH, and IGF-1 levels during the onset of puberty may lead to higher α-Klotho levels.…”