Analysis of Serum Uric Acid Levels in Early Second Trimester as an Early Predictor for Preeclampsia

Bulusu, Ratna; Singh, Trishla

doi:10.18410/jebmh/2017/23

Cited by 4 publications

(4 citation statements)

References 14 publications

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“…Also, it was found that in HDP the elevation of uric acid occurs before the onset of hypertension and or proteinuria [13, 14]. There are many reasons for raised serum uric acid levels in women with HDP, which include impaired clearance from kidneys, increased tissue breakdown, acidosis and increased activity of xanthine oxidase/dehydrogenase enzyme [14, 15]. The main reason behind impaired renal clearance of uric acid is reduced glomerular filtration rate, increased absorption and decreased secretion leading to raising serum uric acid levels in women with HDP [14].…”

Section: Introductionmentioning

confidence: 99%

Maternal Serum Uric Acid as a Predictor of Severity of Hypertensive Disorders of Pregnancy: A Prospective Cohort Study

Kumar

Singh

2019

CHYR

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Objective: To assess the relationship between maternal serum uric acid and severity of Hypertensive disorders of pregnancy in a rural tertiary care centre. Materials and Methods: Present study was conducted in Obstetrics and Gynaecology department of rural tertiary care centre of Northern India over seven months (October 2016-May 2017) on 110 women admitted with a Hypertensive disorder of pregnancy (Gestational hypertension, Preeclampsia, Eclampsia) at ≥;34 weeks gestation. Maternal serum uric acid levels were compared in three groups in relation to disease severity, mode of delivery, maternal outcome. Results: Of total 110 women with a Hypertensive disorder of pregnancy; 35 (31.81%) had Gestational Hypertension, 49 (44.54%) preeclampsia and 26 (23.63%) had eclampsia. Mean±SD values for serum uric acid were 5.47±1.93 mg/dl in women with Gestational Hypertension; 6.72±2.15 mg/dl in Pre-eclampsia and 8.71±2.97 mg/dl in the eclamptic group. Of 110 women 34(97.14%) with gestational hypertension, 27(55.10%) with pre-eclampsia and one (3.85%) with eclampsia remained stable in post-partum period, 17 (34.69%) women with severe pre-eclampsia and 15 (57.69%) with eclampsia required intensive care in postpartum period and one (2.86%) women with gestational hypertension, five (10.20%) with pre-eclmapsia and ten (38.46%) with eclampsia required ventilator support and high dependency unit care. Of these 16 women with the severe disease, ten succumbed to death. Also, in women with serum uric acid,>6mg/dl, most common mode of delivery was a lower segment cesarean section (50.90%). Conclusion: Significant correlation was observed between maternal serum uric acid, disease severity and maternal outcome.

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Section: Introductionmentioning

confidence: 99%

Maternal Serum Uric Acid as a Predictor of Severity of Hypertensive Disorders of Pregnancy: A Prospective Cohort Study

Kumar

Singh

2019

CHYR

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“…A decrease in the serum uric acid level to about to 3 mg/dL or more has been observed during the first trimester in pregnant women, due to higher blood flow in kidney and uricosuric effects of estrogen. 9 Followed by this, an elevation in the serum uric acid level occurs in the third trimester, reaching up to 4-5 mg/dL at term. However, a slightly higher serum uric acid level was observed in HDP prone pregnant women, especially in the first trimester of their pregnancy.…”

Section: Introductionmentioning

confidence: 91%

“…7 Impaired renal clearance of uric acid, elevated breakdown of tissues, acidosis, and an increase in dehydrogenase or xanthine oxidase enzyme were believed to be the reasons for higher levels of uric acid levels in the serum of pregnant women with HDP. 8,9 A reduction in the rate of glomerular filtration is the main reason for impaired clearance of uric acid from kidney, reduction in secretion and elevated absorption results in higher serum uric acid levels in individuals with HDP. A decrease in the serum uric acid level to about to 3 mg/dL or more has been observed during the first trimester in pregnant women, due to higher blood flow in kidney and uricosuric effects of estrogen.…”

Section: Introductionmentioning

confidence: 99%

Effect of serum uric acid level on maternal and neonatal outcome in patients with hypertensive disorders of pregnancy at HSK Hospital, Bagalkot: A prospective and observational study

et al. 2022

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Background: Uric acid, a metabolite of purine metabolism, is considered as a marker of hypertensive disorder of pregnancy (HDP) severity. An increase in serum uric acid level in pregnant mothers has been found to be associated with the disease severity. Aims and Objectives: The present study intended to evaluate the effect of serum uric acid level in maternal and neonatal outcome in cases of hypertensive disorders of pregnancy. Materials and Methods: This prospective and observational study was conducted on patients with HDP from December 2017 to April 2019. The study was conducted on 274 subjects who visited the Department of Obstetrics and Gynecology, HSK Hospital, Bagalkot. The participants were categorized into two groups according to their serum uric acid level (<6 mg/dL and ≥6 mg/dL). Serum uric acid was estimated by enzymatic colorimetric method. Maternal and neonatal outcomes were recorded. Follow-up was done till the discharge of the mother and child from the hospital. Data were analyzed using coGuide software. Results: The majority of the participants were in the age group of 18–23 year (52.91%). No significant association was observed between serum uric acid groups and maternal parameters such asparity, gestational age, onset of labor, mode of delivery, and maternal complications (P>0.05). There was statistically no significant difference between serum uric acid groups in neonatal outcomes such as Apgar score 1 min and 5 min, IGUR, NICU admission, and reason for NICU admission (P>0.05) except for still birth. Still birth was found to be more in patients with serum uric acid ≥6mg/dl (19.64%) group compared to <6 mg/dl (8.64%) with P=0.008. Conclusion: This study shows that there was no significant association between adverse maternal and neonatal outcomes with increased level of serum uric acid.

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“…SUA levels increase in HDP due to tissue breakdown, acidosis, decreased renal clearance, and increased activity of the xanthine oxidase/dehydrogenase enzyme [ 4 , 5 ]. In the first trimester, uric acid levels are <3 mg/dL due to uricosuria and increased renal blood flow (estrogen effect).…”

Section: Introductionmentioning

confidence: 99%

Serum Uric Acid Levels as a Risk Stratification Tool in Hypertensive Disorders of Pregnancy: A Retrospective Study

Singh,

Agarwal,

Singh

et al. 2024

Cureus

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Background: Worldwide, hypertensive disorders of pregnancy (HDP) are among the leading causes of maternal and fetal morbidity and mortality. Serum uric acid is a test that can evaluate the severity of HDP and the associated maternal and fetal morbidity and mortality. Aim: To examine the relationship between maternal serum uric acid levels and the severity of HDP and overall pregnancy outcomes. Material and methods: A retrospective study was conducted on women with a gestational age > 20 weeks and BP >140/90 mmHg over three years. A total of 134 patients were included in the study. Patients with chronic hypertension, hyperuricemia without hypertension, and other major illnesses were excluded. Data were collected from medical records, including age, gravida, parity, weight, height, gestational age, blood pressure at admission, urine albumin, and serum uric acid levels. Results: Of the 134 enrolled women with HDP, 76 had gestational hypertension, 41 had preeclampsia, and 17 had eclampsia. Mean uric acid levels in mg/dL were 6.06±1.651, 6.20±0.824, and 7.38±1.26 in gestational hypertension, preeclampsia, and eclampsia, respectively, which was a significant association (p=0.002). Mean uric acid in mg/dL was 5.86±1.27 in intensive care unit (ICU) patients compared to 6.45±1.39 in ward patients (p=0.015). There was a significantly increased risk of ICU admission and preterm delivery (r=-0.401, p<0.001) in patients with elevated uric acid levels. There was a significantly increased risk of low-birth-weight babies with elevated uric acid levels (r=-0.278, p=0.001). However, there was no statistically significant increased risk of newborn intensive care unit admissions (p=0.264) with elevated uric acid levels. Conclusion: Serum uric acid levels vary significantly in HDP and were found to be elevated in severe preeclampsia and eclampsia. It can be considered for risk stratification in HDP based on disease severity; however, its role in determining outcomes is debatable. Using serum uric acid levels in predictive models along with known biomarkers may determine its possible additional value in disease prediction and severity.

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Analysis of Serum Uric Acid Levels in Early Second Trimester as an Early Predictor for Preeclampsia

Cited by 4 publications

References 14 publications

Maternal Serum Uric Acid as a Predictor of Severity of Hypertensive Disorders of Pregnancy: A Prospective Cohort Study

Maternal Serum Uric Acid as a Predictor of Severity of Hypertensive Disorders of Pregnancy: A Prospective Cohort Study

Effect of serum uric acid level on maternal and neonatal outcome in patients with hypertensive disorders of pregnancy at HSK Hospital, Bagalkot: A prospective and observational study

Serum Uric Acid Levels as a Risk Stratification Tool in Hypertensive Disorders of Pregnancy: A Retrospective Study

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