2020
DOI: 10.1101/2020.06.06.138362
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Analysis of single-cell RNA-seq data from ovarian cancer samples before and after chemotherapy links stress-related transcriptional profile with chemotherapy resistance

Abstract: The authors declare no potential conflicts of interest. 1 Translational relevanceWe discovered a stress-related transcriptional profile that is significantly enriched in fresh tissue samples after chemotherapy and is significantly associated with poor progression-free survival in an independent patient cohort. The survival association is independent of age, tumor purity or BRCAness. Therefore, this chemotherapy resistance associated profile is intrinsic and could thus be targeted already in treatment-naive pat… Show more

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Cited by 2 publications
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“…Ovarian tumors exhibit significant intercellular heterogeneity in response to drugs, with most cancer cells succumbing to therapeutic pressure while some persistent cells survive drug exposure 6,[8][9][10][11][12][13][14] . Singlecell RNA sequencing data has unveiled that these resistant subpopulations of ovarian cancer cells either exist at the beginning of tumorigenesis and expand after chemotherapy 15,16 or are generated during chemotherapy 12 . However, the precise mechanism driving the accelerated expansion of therapy-resistant clones remains elusive.…”
mentioning
confidence: 99%
“…Ovarian tumors exhibit significant intercellular heterogeneity in response to drugs, with most cancer cells succumbing to therapeutic pressure while some persistent cells survive drug exposure 6,[8][9][10][11][12][13][14] . Singlecell RNA sequencing data has unveiled that these resistant subpopulations of ovarian cancer cells either exist at the beginning of tumorigenesis and expand after chemotherapy 15,16 or are generated during chemotherapy 12 . However, the precise mechanism driving the accelerated expansion of therapy-resistant clones remains elusive.…”
mentioning
confidence: 99%