2014
DOI: 10.2147/ijn.s58203
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Analysis of SiO2 nanoparticles binding proteins in rat blood and brain homogenate

Abstract: A multitude of nanoparticles, such as titanium oxide (TiO 2 ), zinc oxide, aluminum oxide, gold oxide, silver oxide, iron oxide, and silica oxide, are found in many chemical, cosmetic, pharmaceutical, and electronic products. Recently, SiO 2 nanoparticles were shown to have an inert toxicity profile and no association with an irreversible toxicological change in animal models. Hence, exposure to SiO 2 nanoparticles is on the increase. SiO … Show more

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Cited by 16 publications
(1 citation statement)
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“…As an example, the composition of the protein corona was studied for four different nanoparticles of SiO2 (combining 20 and 100 nm, with positive and negative charges), taking into account the composition in proteins specific to blood compared to brain homogenates. In plasma, the corona is mainly made of albumin, lipoprotein and proteins related to coagulation, while in the brain, it is mainly composed of tubulin, suggesting completely different interactions and functions of these nanoparticles in brain tissue (Shim et al, 2014). These major obstacles to assessing the neurotoxicity of nanoparticles are summarized in Figure 4.…”
Section: Gaps In Research and Methodological Challengesmentioning
confidence: 99%
“…As an example, the composition of the protein corona was studied for four different nanoparticles of SiO2 (combining 20 and 100 nm, with positive and negative charges), taking into account the composition in proteins specific to blood compared to brain homogenates. In plasma, the corona is mainly made of albumin, lipoprotein and proteins related to coagulation, while in the brain, it is mainly composed of tubulin, suggesting completely different interactions and functions of these nanoparticles in brain tissue (Shim et al, 2014). These major obstacles to assessing the neurotoxicity of nanoparticles are summarized in Figure 4.…”
Section: Gaps In Research and Methodological Challengesmentioning
confidence: 99%