Though it is long known that irregular intake of antihypertensive may cause harm, but still there is much lack of awareness among the patients in this matter. This case controlled study was done in Dhaka Medical College Hospital, Dhaka, to determine the relationship between discontinuation of antihypertensive drugs and the risk of stroke among hypertensive patients. Number of cases was 72. Control group was selected via random sampling of stroke free treated hypertensive group, similar in age to stroke cases. Sampling technique was random systematic sampling. The relationship was determined employing statistical methods including Chi-square (?2) test using computer programs, and significant association between discontinuation of antihypertensive and development of stroke in hypertensive adult patients was found ?2(1,N= 103) = 32.637, p<0.001. OddÂ’s ratio is 15.83. DOI: http://dx.doi.org/10.3329/jdmc.v22i2.21530 J Dhaka Medical College, Vol. 22, No.2, October, 2013, Page 173-178