The current education and teaching reforms are constantly creating a “student-centered, teacherled” teaching model, and promote the development of education and teaching in a personalized direction. Therefore, cultivating and improving the learning ability of college students through personalized network teaching mode has become one of the hot issues in the current education and teaching reform and development. The purpose of this paper is to study the personalized reform of computer education based on the network teaching model, based on the constructivist learning theory, combined with the research results of artificial intelligence, to the knowledge representation, student personality evaluation and teaching strategy decisionmaking in the personalized computer-assisted teaching system research and exploration have been carried out on other issues, forming a network teaching system with certain intelligence. In computer teaching, “Configuring Computer” is used as the learning theme to compare the advantages and disadvantages of personalized network teaching and traditional network teaching. A detailed analysis of the two inquiry learning and a more in-depth reflection were carried out. The experimental results show that the students’ inquiry cooperation ability and the quality of works in personalized online teaching have been improved to varying degrees. On the whole, the ratio of excellent to good in learning evaluation increased, and the ratio of medium to poor decreased, and the quality of multimedia works of more than 13% of students improved to excellent. The two teachings were carried out smoothly and basically achieved the expected goals proposed in this article.