Analysis of spontaneous alcohol drinking in rhesus monkeys

Kornet, M.; Goosen, C.; Ribbens, L. G.; Ree, Jan M. van

doi:10.1016/0031-9384(90)90077-h

Cited by 21 publications

(9 citation statements)

References 35 publications

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“…In these alcohol-preferring animals, consumption increases over time, and behavioral symptoms of withdrawal are seen if ethanol is abruptly withheld after several weeks of continuous drinking. In our studies, as in those of other investigators (Crowley et al 1990;Kornet et al 1990;Higley et al 1991), monkeys drink in social settings as well as in isolation (Ervin et al 1990) and the individual level of alcohol consumption is stable over time (Palmour et al 1995).…”

Section: Introductionsupporting

confidence: 57%

An amino acid mixture deficient in phenylalanine and tyrosine reduces cerebrospinal fluid catecholamine metabolites and alcohol consumption in vervet monkeys

et al. 1998

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An amino acid mixture devoid of tryptophan, given orally, was previously shown to reduce cerebrospinal fluid levels of tryptophan and 5-hydroxyindoleacetic acid in vervet monkeys, as compared to a control mixture containing all essential amino acids. In the present study, we tested the possibility that a similar amino acid mixture containing tryptophan, but devoid of phenylalanine and tyrosine (the amino acid precursors of catecholamine neurotransmitters), would influence dopamine and noradrenaline metabolism. Five hours after the administration of this mixture to vervet monkeys, cerebrospinal fluid levels of homovanillic acid and 3-methoxy-4-hydroxyphenylethylene glycol were reduced by 27.4% and 26.9%, respectively. Both effects were statistically significant. Plasma tyrosine (-30%) and the ratio of tyrosine to the sum of other large neutral amino acids (sigmaLNAA) were also significantly reduced. The behavioral efficacy of phenylalanine/tyrosine depletion was compared with that of tryptophan depletion in a primate model of voluntary alcohol consumption. All three drinks lowered alcohol consumption, but the effects of the tryptophan-deficient amino acid mixture were not different from those of the balanced amino acid control. The phenylalanine/tyrosine-deficient drink differentially lowered alcohol consumption, consistent with other data in this species and elsewhere implicating dopamine in the rewarding effects of alcohol.

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Section: Introductionsupporting

confidence: 57%

An amino acid mixture deficient in phenylalanine and tyrosine reduces cerebrospinal fluid catecholamine metabolites and alcohol consumption in vervet monkeys

et al. 1998

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“…The ADE is a robust phenomenon evident in rats (Backstrom et al, 2004b; Bell et al, 2004; Colombo et al, 2003; Dayas et al, 2004; Fullgrabe et al, 2007; Funk et al, 2004; Heyser et al, 1997; Holter et al, 2000; McKinzie et al, 1998; Oster et al, 2006; Rodd-Henricks et al, 2001; Rodd-Henricks et al, 2000a; Rodd-Henricks et al, 2000b; Rodd et al, 2003; Rodd et al, 2006; Serra et al, 2003; Vengeliene et al, 2005; Vengeliene et al, 2006; Wolffgramm and Heyne, 1995), mice (Cowen et al, 2003a; Cowen et al, 2003b; Khisti et al, 2006; Melendez et al, 2006; Sanchis-Segura et al, 2006; Zghoul et al, 2007), monkeys (Kornet et al, 1990; Sinclair, 1971) and humans (Burish et al, 1981; Mello, 1972). The ADE can be seen at ethanol deprivation intervals as short as 12-hours (Sinclair et al, 1989) or as long as 75-days (Sinclair, 1973), and has been shown to increase in magnitude and duration following multiple cycles of ethanol deprivation in alcohol preferring (P) rats and high alcohol drinking (HAD) rats (Breese et al, 2004; McKinzie et al, 1998; Rodd-Henricks et al, 2001; 2002a; b; Rodd et al, 2003).…”

Section: Introductionmentioning

confidence: 99%

The Alcohol Deprivation Effect in C57BL/6J Mice is Observed Using Operant Self‐Administration Procedures and is Modulated by CRF‐1 Receptor Signaling

Sparta

Ferraro

Fee

et al. 2008

Alcoholism Clin & Exp Res

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Background: The alcohol deprivation effect (ADE) is characterized by transient excessive alcohol consumption upon reinstatement of ethanol following a period of ethanol deprivation. While this phenomenon has been observed in rats using both bottle drinking (consummatory behavior) and operant self-administration (consummatory and appetitive ''ethanol-seeking'' behavior) procedures, ADE studies in mice have primarily relied on bottle drinking measures. Furthermore, the neurochemical pathways that modulate the ADE are not well understood. Therefore, we determined whether the ADE can be observed in C57BL ⁄ 6J mice using operant self-administration procedures and if expression of the ADE is modulated by the corticotropin releasing factor-1 (CRF-1) receptor.Methods: C57BL ⁄ 6J mice were trained in a 2-hour operant self-administration paradigm to lever press for 10% ethanol or water on separate response keys. Between operant sessions, mice had access to ethanol in their homecage. Once stable responding occurred, mice were deprived of ethanol for 4 days and were then retested with ethanol in the operant paradigm for 3 consecutive days. Next, to assess the role of the CRF-1 receptor, mice were given intraperitoneal (i.p.) injection (0, 10, or 20 mg ⁄ kg) of the CRF-1 receptor antagonist CP-154,526 30 minutes before ADE testing. Additional experiments assessed (i) ADE responding in which the alternate response lever was inactive, (ii) the effects of CP-154,526 on self-administration of a 1% sucrose solution following 4 days of deprivation, and (iii) ADE responding in which mice did not received i.p. injections throughout the experiment.Results: Mice exhibited a significant increase in postdeprivation lever responding for ethanol with either a water reinforced or inactive alternate lever. Interestingly, i.p. injection of a 10 mg ⁄ kg dose of CP-154,526 protected against the ADE while not affecting lever responding for a sucrose solution. Finally, baseline and deprivation-induced increases of ethanol reinforced lever responding were greater in mice not given i.p. injections.Conclusions: The ADE in C57BL ⁄ 6J mice can be modeled using the operant self-administration paradigm and increased ethanol self-administration associated with the ADE is modulated by CRF-1 receptor signaling.

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“…Several studies have shown that oral alcohol functions as a reinforcer in non-deprived Old World monkeys (Ator and Griffiths 1992; Kornet et al 1990; Stewart et al 1996). Voluntary alcohol drinking has been successfully established in socially housed rhesus macaques without food and water deprivation (Barr et al 2004b; Fahlke et al 2000; Higley et al 1991).…”

mentioning

confidence: 99%

Social rank and social separation as determinants of alcohol drinking in squirrel monkeys

McKenzie-Quirk

Miczek

2008

Psychopharmacology

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Rationale Alcohol may be self-administered for its anxiolytic effects to alleviate symptoms of stress, but different types of stressors have varying effects on alcohol intake. Social stress is particularly relevant to alcohol drinking, and a primate model of stress-induced alcohol self-administration would be useful. Objective The objective of the study is to determine if social stresses of different lengths and intensities affect voluntary alcohol intake in monkeys. Materials and methods Subjects were adult male and female squirrel monkeys (Saimiri sciureus) housed in social colonies. Subjects were trained to drink a solution of ethanol and sucrose, alternated daily with a control solution of quinine and an equal concentration of sucrose in 15-min sessions. Drinking was tested during 20-min acute, social separations and 1-week, extended, social separations. Dominance status was quantified using observational records of social interactions within the colonies. Salivary cortisol was sampled in the home colony and during extended social separation. Results Dominance rank was inversely correlated with alcohol intake during social housing but was not correlated with control fluid intake. Acute social separation abolished drinking of both fluids, accompanied by increased anxiety-like behavior. Extended social separation increased salivary cortisol and alcohol drinking but not control fluid intake in males. In females, drinking was unchanged by extended separation. Conclusions The chronic stress of social subordination is correlated with increased alcohol drinking. Acute social separation stress suppresses drinking behavior, while extended separation preferentially increases alcohol intake in a subset of individuals. These findings suggest that social stressors of different time-courses and intensities have opposing effects on alcohol self-administration.

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Analysis of spontaneous alcohol drinking in rhesus monkeys

Cited by 21 publications

References 35 publications

An amino acid mixture deficient in phenylalanine and tyrosine reduces cerebrospinal fluid catecholamine metabolites and alcohol consumption in vervet monkeys

An amino acid mixture deficient in phenylalanine and tyrosine reduces cerebrospinal fluid catecholamine metabolites and alcohol consumption in vervet monkeys

The Alcohol Deprivation Effect in C57BL/6J Mice is Observed Using Operant Self‐Administration Procedures and is Modulated by CRF‐1 Receptor Signaling

Social rank and social separation as determinants of alcohol drinking in squirrel monkeys

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