1994
DOI: 10.1007/s004010050073
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Analysis of staining methods for different cortical plaques in Alzheimer's disease

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Cited by 3 publications
(5 citation statements)
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“…Both Braak and Thal have shown that the Campbell‐Switzer silver stain very closely corresponds with IHC methods for Aβ . Previous and subsequent studies have also supported that IHC is not always or necessarily more sensitive than all other methods . We have demonstrated the equivalency of Campbell‐Switzer and IHC methods for Aβ in an imaging‐to‐autopsy study of an amyloid imaging agent, F18 florbetapir, where cortical amyloid standardized uptake value ratio correlated with similar strength to plaque densities estimated with both Campbell‐Switzer (Spearman rho = 0.76; P < 0.0001) and Aβ IHC (Spearman rho = 0.71; P < 0.001).…”
Section: Introductionsupporting
confidence: 59%
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“…Both Braak and Thal have shown that the Campbell‐Switzer silver stain very closely corresponds with IHC methods for Aβ . Previous and subsequent studies have also supported that IHC is not always or necessarily more sensitive than all other methods . We have demonstrated the equivalency of Campbell‐Switzer and IHC methods for Aβ in an imaging‐to‐autopsy study of an amyloid imaging agent, F18 florbetapir, where cortical amyloid standardized uptake value ratio correlated with similar strength to plaque densities estimated with both Campbell‐Switzer (Spearman rho = 0.76; P < 0.0001) and Aβ IHC (Spearman rho = 0.71; P < 0.001).…”
Section: Introductionsupporting
confidence: 59%
“…[87][88][89][90] Previous and subsequent studies have also supported that IHC is not always or necessarily more sensitive than all other methods. [91][92][93][94][95] We have demonstrated the equivalency of Campbell-Switzer and IHC methods for Aβ in an imaging-to-autopsy study of an amyloid imaging agent, F18 florbetapir, 96,97 where cortical amyloid standardized uptake value ratio correlated with similar strength to plaque densities estimated with both Campbell-Switzer (Spearman rho = 0.76; P < 0.0001) and Aβ IHC (Spearman rho = 0.71; P < 0.001). Additionally, the validity and accuracy of the Campbell-Switzer method has also been established through strong correlations with autoradiographic binding of F18 florbetapir 98 in post-mortem human brain sections (Spearman rho = 0.95; P < 0.0001).…”
Section: Diagnostic Stainsmentioning
confidence: 70%
“…The number of senile plaques has been shown to differ according to fixation and staining procedures [ 2 3 . 27,651. It is now generally accepted that there are four categories of plaques: diffuse, containing amorphous non-neuritic amyloid material, primitive containing amyloid fibrils and aggregation of neuritic fibres without a (0 1995 Blackwell Science Ltd. Neuropathology and Applied Neurobiologg.…”
Section: Discussionmentioning
confidence: 99%
“…[410][411][412][413][414][415][416][417][418][419][420][421][422] core. classical with neuritic fibres and a compact arnyloid core and finally compact cored deposits [27]. The periodic acid methenamine technique demonstrates as many senile plaques as the p immunostaining, revealing mainly the p amyloid component of the difiuse, primitive and classical plaques [ 2 3 , 34,53,661.…”
Section: Discussionmentioning
confidence: 99%
“…1). A modified Bielschowsky silver stain was used to assess the tissue for protein fibrils, including NFTs as previously described [30].…”
Section: Immunohistochemistrymentioning
confidence: 99%