Analysis of Surgical Salvage After Failure of Primary Therapy in Rectal Cancer: Results From Intergroup Study 0114

Tepper, Joel E.; O’Connell, Michael J.; Hollis, Donna; Niedzwiecki, Donna; Cooke, E. M.; Mayer, Robert J.

doi:10.1200/jco.2003.03.018

Cited by 91 publications

(47 citation statements)

References 28 publications

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“…This supports the contention that haematogenous spread via the iliac veins results in a higher incidence of lung metastases from rectal cancer. 13,14 By contrast, locoregional recurrence of rectal tumors was relatively uncommon and certainly no more frequent than colonic tumors. This is consistent with the modern use of surgical techniques to ensure a complete excision of the mesorectum selectively combined with the use of chemoradiotherapy that has dramatically reduced the rates of locoregional recurrence from rectal cancer.…”

Section: Discussionmentioning

confidence: 99%

Site and Stage of Colorectal Cancer Influence the Likelihood and Distribution of Disease Recurrence and Postrecurrence Survival

et al. 2016

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Running head: Analysis of recurrence in the FACS study Mini AbstractRecurrence is a frequent cause of mortality following treatment for colorectal cancer with curative intent. This retrospective cohort analysis examines patterns of recurrence, and factors determining post-recurrence survival, in a large cohort of accurately staged patients treated curatively for DukesÕ A-C primary colorectal cancer from the FACS randomised controlled trial. 1 Structured Abstract ObjectiveTo describe patterns of recurrence and post-recurrence survival (PRS) in a large cohort of accurately staged patients with DukesÕ A-C colorectal cancer (CRC). BackgroundRecurrence remains a frequent cause of mortality following the treatment of CRC with curative intent. Understanding the likelihood and site of recurrence informs adjuvant treatment and follow-up. MethodsRetrospective cohort analysis of data from the FACS (Follow-up after Colorectal Cancer Surgery) trial after a median 4.4 years follow-up; PRS was calculated using the Kaplan-Meier method. ResultsComplete data were available for 94% of patients; 189 (17%) had experienced recurrence.

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Section: Discussionmentioning

confidence: 99%

Site and Stage of Colorectal Cancer Influence the Likelihood and Distribution of Disease Recurrence and Postrecurrence Survival

et al. 2016

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“…This rate exceeds the approximate 10% rate typically reported in the literature. Given that patients with isolated lung metastases often experience excellent 5-year survival rates (27% to 41%), [8][9][10] we would recommend that patients undergo some manner of chest imaging as part of their postoperative surveillance approach. Whether annual CT of the chest is superior to a twice yearly CXR cannot be resolved at this juncture.…”

Section: Discussionmentioning

confidence: 99%

Postoperative Surveillance Recommendations for Early Stage Colon Cancer Based on Results From the Clinical Outcomes of Surgical Therapy Trial

Tsikitis

Malireddy

Green

et al. 2009

JCO

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A B S T R A C T PurposeIntensive postoperative surveillance is associated with improved survival and recommended for patients with late stage (stage IIB and III) colon cancer. We hypothesized that stage I and IIA colon cancer patients would experience similar benefits. Patients and Methods ConclusionPatients with early-stage colon cancer have similar sites of recurrence, and receive similar benefit from postrecurrence therapy as late-stage patients; implementation of surveillance guidelines for early-stage patients is appropriate.

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“…Liver is the commonest site of recurrence in people who undergo curative surgery for colorectal cancer [3, 4] and 20–32% of these metastatic deposits are respectable [4–6]. The 5-year survival after liver resection varies between 16% and 30% [5, 7–10].…”

Section: Introductionmentioning

confidence: 99%

Management of the Hepatic Lymph Nodes during Resection of Liver Metastases from Colorectal Cancer: A Systematic Review

2008

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Background. Hepatic lymph node involvement is generally considered a contraindication for liver resection performed for colorectal liver metastases. However, some advocate hepatic lymphadenectomy in the presence of macroscopic involvement and others routine lymphadenectomy. The aim of this review is to assess the role of lymphadenectomy in resection of liver metastases from colorectal cancer. Methods. Medline, Embase and Central databases were searched using a formal search strategy. Trials with survival data with a minimum follow-up of 1 year were considered for inclusion. Meta-analysis was performed using Revman. Results. A total of 4230 references were identified. Ten reports of nine studies including 926 patients qualified for the review. The prevalence of nodal metastases after routine lymphadenectomy was 16.3%. The overall 3-year and 5-year survival rates in node-positive patients were 9/151 (11.3%) and 2/137 (1.5%), respectively, compared to 3-year and 5-year survival rates of 424/787 (53.9%) and 246/767 (32.1%) in node-negative patients. The odds ratios for 3-year and 5-year survivals in node positive disease compared to node-negative disease were 0.12 (95% CI 0.06 to 0.24) and 0.08 (95% CI 0.03 to 0.22). There was no randomized controlled trial which assessed the survival benefit of routine or “selective” lymphadenectomy. Conclusion. Currently, there is no evidence of survival benefit for routine or selective lymphadenectomy. Survival rates are low in patients with positive lymph nodes draining the liver irrespective of whether they are detected by routine lymphadenectomy or by macroscopic involvement. Further trials in this patient group are required.

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Analysis of Surgical Salvage After Failure of Primary Therapy in Rectal Cancer: Results From Intergroup Study 0114

Abstract: Attempted surgical salvage of rectal cancer recurrence is performed commonly in the United States. The chance of a long-term cure with such intervention is approximately 27%.

Cited by 91 publications

References 28 publications

Site and Stage of Colorectal Cancer Influence the Likelihood and Distribution of Disease Recurrence and Postrecurrence Survival

Site and Stage of Colorectal Cancer Influence the Likelihood and Distribution of Disease Recurrence and Postrecurrence Survival

Postoperative Surveillance Recommendations for Early Stage Colon Cancer Based on Results From the Clinical Outcomes of Surgical Therapy Trial

Management of the Hepatic Lymph Nodes during Resection of Liver Metastases from Colorectal Cancer: A Systematic Review

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