2023
DOI: 10.3389/fsurg.2022.1020240
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Analysis of survival factors after hepatic resection for colorectal cancer liver metastases: Does the R1 margin matter?

Abstract: IntroductionThe effect of liver margin on colorectal cancer liver metastases (CRLM) after hepatectomy has been controversial. In this study, we conducted a postoperative follow-up study of 205 patients with CRLM to clarify whether a positive margin is significant and to define the risk factors affecting CRLM survival.MethodsThe data of 205 patients with CRLM who underwent surgical treatment at the Third Hospital of Peking University in the Department of General Surgery from January 2009 to December 2020 were r… Show more

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Cited by 2 publications
(3 citation statements)
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“…The most influential predictors were associated with a high disease burden, like multiple and/or large metastatic lesions, originating from a node-positive primary located mostly in the ascending colon, combined with a high CEA level and a positive resection margin. These factors have already been identified in multiple studies as predictors of poor survival in CRLM patients [92][93][94]. The presence of a mutant RAS oncogene was also highlighted as a key predictor in this review, which confirms the findings of a meta-analysis showing the poor OS and RFS following resection of CRLM in mutant KRAS patients [95].…”
Section: Critical Appraisal Of Published Modelssupporting
confidence: 86%
“…The most influential predictors were associated with a high disease burden, like multiple and/or large metastatic lesions, originating from a node-positive primary located mostly in the ascending colon, combined with a high CEA level and a positive resection margin. These factors have already been identified in multiple studies as predictors of poor survival in CRLM patients [92][93][94]. The presence of a mutant RAS oncogene was also highlighted as a key predictor in this review, which confirms the findings of a meta-analysis showing the poor OS and RFS following resection of CRLM in mutant KRAS patients [95].…”
Section: Critical Appraisal Of Published Modelssupporting
confidence: 86%
“…Surgical resection stands as a primary and potentially curative treatment approach for patients diagnosed with colorectal cancer with multiple liver metastases [1]. The objective of surgical resection is to eliminate the metastatic tumors within the liver through the complete removal of visible tumors and attainment of negative surgical margins.…”
Section: Surgical Treatmentmentioning
confidence: 99%
“…Factors such as the number, size, location, and distribution of liver metastases are key considerations in determining the appropriateness of surgical resection [1]. For patients with a limited number of metastases that are well-positioned and resectable, complete tumor removal becomes a viable option.…”
Section: Surgical Treatmentmentioning
confidence: 99%