The aim of the study was to investigate trigeminal function in children compared with that of adults. Trigeminal sensitivity was assessed using a lateralization task where participants were requested to identify the side of the nose to which an odorous stimulus was presented. The ability to localize the sensation is largely based on trigeminal function. A total of 344 people participated (191 females, 153 males; mean age 12y [SD 7y 9mo], range 5-54y). Eucalyptol (EUC) was administered as a mixed olfactory-trigeminal stimulant; phenylethyl alcohol (PEA) was used as a control stimulant with minimal trigeminal impact. In addition, sensitivity to vibration was assessed as a somatosensory control. With regard to all age groups, PEA could not be localized whereas this was easily possible for EUC. However, the ability to localize EUC increased with age, which was not the case for PEA. No sex-related difference was found for odour localization. These results provide data for normal intranasal trigeminal function in children. They also indicate that trigeminal sensitivity is already well-developed in children.Little is known about intranasal trigeminal chemosensory function in children. Anatomical studies suggest that the differentiation of the trigeminal nerves occurs approximately at prenatal week 7; and behavioral studies of preterm infants suggest that nasal chemosensitivity to odorants with both trigeminal and olfactory properties are already present by about prenatal week 28. 1 However, the course of development of chemosensory intranasal trigeminal function during childhood is unclear.Some studies refer to the state of development from an anatomical perspective. 2-5 From a behavioral point of view, studies refer either to olfaction, 6,7-9 or gustation, [10][11][12] or to the somatosensory system in general. For example, Allison et al, 13 Ferri et al, 14 and Opsommer and Plaghki 15 took a behavioural approach to research; however, intranasal trigeminal chemosensory function has received little attention. [13][14][15] Assessment of intranasal trigeminal function should take into account perceptual attention skills of children. Attention has been noted as limited when chemosensory stimuli are presented, 16,17 which has also been noted for other senses, for example, hearing. [18][19][20] Nevertheless, in the area of sensory analysis, Laing 21 maintains that, by 8 years of age, the attention span of children -even in the most demanding detection studies -appears to be similar to that of adults; and that measurements of, for example, olfactory sensitivity provide consistent results in younger children.Despite this, chemosensory intranasal trigeminal function in children has not yet been examined systematically. As a major function of the intranasal trigeminal system is to sense irritants and potentially toxic chemicals, 22,23 development of a simple screening test for intranasal trigeminal sensitivity could provide clinicians with a valuable tool when investigating possible damage from nasal surgery, diseases, exposure ...