Analysis of Tear Cytokines and Clinical Correlations in Sjögren Syndrome Dry Eye Patients and Non–Sjögren Syndrome Dry Eye Patients

Lee, Sang Yeop; Han, Suk Won; Nam, Sang Min; Yoon, Sangchul; Ahn, Ji Min; Kim, Tae Im; Kim, Eung Kweon; Seo, Kyoung Yul

doi:10.1016/j.ajo.2013.04.003

Cited by 169 publications

(130 citation statements)

References 38 publications

Supporting

Mentioning

118

Contrasting

Unclassified

Order By: Relevance

“…Due to ethical and technical problems in histological studies of human lacrimal glands, tears represent a powerful tool to investigate pSS-dry eye. Although lacrimal IL-17 is increased in dry eye syndrome of different etiology in humans and animal models [75][76][77] such increase is significantly more pronounced in pSS patients compared to those with non-pSS dry eye syndrome. In addition, a parallel elevation of IL-6 has been also observed in pSS tears, suggesting an underlying loop to maintain Th17 response in lacrimal glands [76].…”

Section: Association Of Il-17/th17 Cells With Histological Pattern Anmentioning

confidence: 95%

Unmasking the pathogenic role of IL-17 axis in primary Sjögren's syndrome: A new era for therapeutic targeting?

Alunno

Carubbi

Bartoloni

et al. 2014

Autoimmunity Reviews

View full text Add to dashboard Cite

Section: Association Of Il-17/th17 Cells With Histological Pattern Anmentioning

confidence: 95%

Unmasking the pathogenic role of IL-17 axis in primary Sjögren's syndrome: A new era for therapeutic targeting?

Alunno

Carubbi

Bartoloni

et al. 2014

Autoimmunity Reviews

View full text Add to dashboard Cite

“…50 In line with immune cell recruitment, T cells have been found in the conjunctivae 51 and elevated levels of inflammatory cytokines have been found in the tears of dry eye patients. 52,53 Specifically, tear levels of IL-2, IL-4, IL-5, IL-6, IL-8, IL-10, IL-17, and tumor necrosis factor-a (TNF-a) have been found to be elevated in dry eye compared with control subjects. 52,53 Environmental stress can also lead to an increase in reactive oxygen species.…”

Section: Inflammationmentioning

confidence: 99%

“…52,53 Specifically, tear levels of IL-2, IL-4, IL-5, IL-6, IL-8, IL-10, IL-17, and tumor necrosis factor-a (TNF-a) have been found to be elevated in dry eye compared with control subjects. 52,53 Environmental stress can also lead to an increase in reactive oxygen species. For example, oxidative stress-induced lipid peroxidation was increased on the conjunctivae of Sjogren's patients as assessed by detection of hexanoyl-lysine (HEL) and 4-hydroxy-2-nonenal (4HNE) protein adducts.…”

Section: Inflammationmentioning

confidence: 99%

Neuropathic ocular pain: an important yet underevaluated feature of dry eye

Galor

Levitt

Felix

et al. 2014

Eye

187

View full text Add to dashboard Cite

Dry eye has gained recognition as a public health problem given its prevalence, morbidity, and cost implications. Dry eye can have a variety of symptoms including blurred vision, irritation, and ocular pain. Within dry eyeassociated ocular pain, some patients report transient pain whereas others complain of chronic pain. In this review, we will summarize the evidence that chronicity is more likely to occur in patients with dysfunction in their ocular sensory apparatus (ie, neuropathic ocular pain). Clinical evidence of dysfunction includes the presence of spontaneous dysesthesias, allodynia, hyperalgesia, and corneal nerve morphologic and functional abnormalities. Both peripheral and central sensitizations likely play a role in generating the noted clinical characteristics. We will further discuss how evaluating for neuropathic ocular pain may affect the treatment of dry eye-associated chronic pain.

show abstract

“…This complex symptomatology leads to the difficulties in Sjögren's syndrome diagnostics, which may require a number of tests including eye examination (e.g. ocular staining score using lissamine green and fluorescein or Schirmer's test), lip biopsy for assessment of the salivary gland tissue, blood tests for autoantibodies, and saliva production test [4,[6][7][8][9].…”

Section: Introductionmentioning

confidence: 99%

Quantitative assessment of oral mucosa and labial minor salivary glands in patients with Sjögren’s syndrome using swept source OCT

Grulkowski

Nowak

Karnowski

et al. 2013

Biomed. Opt. Express

View full text Add to dashboard Cite

Three-dimensional imaging of the mucosa of the lower lip and labial minor salivary glands is demonstrated in vivo using swept source optical coherence tomography (OCT) system at 1310 nm with modified interface. Volumetric data sets of the inner surface of the lower lip covering ~230 mm 2 field are obtained from patients with Sjögren's syndrome and a control group. OCT enables high-resolution visualization of mucosal architecture using cross-sectional images as well as en-face projection images. Comprehensive morphometry of the labial minor salivary glands is performed, and statistical significance is assessed. Statistically significant differences in morphometric parameters are found when subgroups of patients with Sjögren's syndrome are analyzed.

show abstract

Analysis of Tear Cytokines and Clinical Correlations in Sjögren Syndrome Dry Eye Patients and Non–Sjögren Syndrome Dry Eye Patients

Cited by 169 publications

References 38 publications

Unmasking the pathogenic role of IL-17 axis in primary Sjögren's syndrome: A new era for therapeutic targeting?

Unmasking the pathogenic role of IL-17 axis in primary Sjögren's syndrome: A new era for therapeutic targeting?

Neuropathic ocular pain: an important yet underevaluated feature of dry eye

Quantitative assessment of oral mucosa and labial minor salivary glands in patients with Sjögren’s syndrome using swept source OCT

Contact Info

Product

Resources

About