Analysis of telomere length and subtelomeric methylation of circulating leukocytes in women with Alzheimer’s disease

Guan, Jing; Guan, Wei; Maeda, Takeshi; Makino, Naoki

doi:10.1007/s40520-013-0006-0

Cited by 26 publications

(18 citation statements)

References 29 publications

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“…Guan et al ( 2012 ) published shorter LTLs and increased oxidative stress in AD patients of both genders, however, after vitamin E administration oxidative stress lowered (Guan et al, 2012 ). Interestingly, one year later they found no significant difference between women with AD and controls but a decreased number of the longest telomeres (>9.4 kb) was observed (Guan et al, 2013 ).…”

Section: Telomere Length In Brainmentioning

confidence: 98%

Telomere Attrition in Neurodegenerative Disorders

Levstek

Kozjek

Dolžan

et al. 2020

Front. Cell. Neurosci.

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Telomere attrition is increased in various disorders and is therefore a potential biomarker for diagnosis and/or prognosis of these disorders. The contribution of telomere attrition in the pathogenesis of neurodegenerative disorders is yet to be fully elucidated. We are reviewing the current knowledge regarding the telomere biology in two common neurodegenerative disorders, Alzheimer’s disease (AD), and Parkinson’s disease (PD). Furthermore, we are discussing future prospective of telomere research in these disorders. The majority of studies reported consistent evidence of the accelerated telomere attrition in AD patients, possibly in association with elevated oxidative stress levels. On the other hand in PD, various studies reported contradictory evidence regarding telomere attrition. Consequently, due to the low specificity and sensitivity, the clinical benefit of telomere length as a biomarker of neurodegenerative disease development and progression is not yet recognized. Nevertheless, longitudinal studies in large carefully selected cohorts might provide further elucidation of the complex involvement of the telomeres in the pathogenesis of neurodegenerative diseases. Telomere length maintenance is a complex process characterized by environmental, genetic, and epigenetic determinants. Thus, in addition to the selection of the study cohort, also the selection of analytical methods and types of biological samples for evaluation of the telomere attrition is of utmost importance.

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Section: Telomere Length In Brainmentioning

confidence: 98%

Telomere Attrition in Neurodegenerative Disorders

Levstek

Kozjek

Dolžan

et al. 2020

Front. Cell. Neurosci.

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show abstract

“…Significant telomere attrition leads to the activation of DNA damage signaling pathways ( Viscardi et al., 2007 ), which induces cell cycle arrest, senescence, and/or cell death. Other consequences of telomere shortening include the alteration of gene expression ( Ye et al., 2014 ), induction of epigenetic modifications and promoter methylation ( Blasco, 2007a ) and altered gene silencing near the telomere ( Guan et al., 2013 ), as well as the alteration of gene expression megabases away from telomeres ( Robin et al., 2014 ). These effects, either individually or in combination, contribute to stem cell dysfunction.…”

Section: Discussionmentioning

confidence: 99%

Single Stem Cell Imaging and Analysis Reveals Telomere Length Differences in Diseased Human and Mouse Skeletal Muscles

et al. 2017

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SummaryMuscle stem cells (MuSCs) contribute to muscle regeneration following injury. In many muscle disorders, the repeated cycles of damage and repair lead to stem cell dysfunction. While telomere attrition may contribute to aberrant stem cell functions, methods to accurately measure telomere length in stem cells from skeletal muscles have not been demonstrated. Here, we have optimized and validated such a method, named MuQ-FISH, for analyzing telomere length in MuSCs from either mice or humans. Our analysis showed no differences in telomere length between young and aged MuSCs from uninjured wild-type mice, but MuSCs isolated from young dystrophic mice exhibited significantly shortened telomeres. In corroboration, we demonstrated that telomere attrition is present in human dystrophic MuSCs, which underscores its importance in diseased regenerative failure. The robust technique described herein provides analysis at a single-cell resolution and may be utilized for other cell types, especially rare populations of cells.

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“…DNA methylation in Alzheimer's disease. Early studies of DNA methylation in LOAD from peripheral blood lymphocytes [19,20], brain biopsies and autopsy material [21][22][23][24][25][26][27][28][29]…”

Section: Gene Regulation Is Achieved By 5mc Silencing Gene Expressionmentioning

confidence: 99%

Epigenetic Factors in Late-Onset Alzheimer’s Disease: <em>MTHFR</em> and<em> CTH </em>Gene Polymorphisms, Metabolic Trans-sulfuration and Methylation Pathways, and B Vitamins

Román¹,

Mancera-Páez²,

Bernal³

2018

Preprint

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DNA methylation and other epigenetic factors are important in the pathogenesis of late-onset Alzheimer’s disease (LOAD).  Methylenetetrahydrofolate reductase (MTHFR) gene mutations occur in most elderly patients with memory loss.  MTHFR is critical for production of S-adenosyl-L-methionine (SAM), the principal methyl donor.  A common mutation (1364T/T) of the cystathionine-γ-lyase (CTH) gene affects the enzyme that converts cystathionine to cysteine in the trans-sulfuration pathway causing plasma elevation of total homocysteine (tHcy) or hyperhomocysteinemia – a strong and independent risk factor for cognitive loss and AD. Other causes of hyperhomocysteinemia include aging, nutritional factors, and deficiencies of B vitamins. We emphasize the importance of supplementing vitamin B12 (methylcobalamin), vitamin B9 (folic acid), vitamin B6 (pyridoxine), and SAM to patients in early stages of LOAD.

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Analysis of telomere length and subtelomeric methylation of circulating leukocytes in women with Alzheimer’s disease

Cited by 26 publications

References 29 publications

Telomere Attrition in Neurodegenerative Disorders

Telomere Attrition in Neurodegenerative Disorders

Single Stem Cell Imaging and Analysis Reveals Telomere Length Differences in Diseased Human and Mouse Skeletal Muscles

Epigenetic Factors in Late-Onset Alzheimer’s Disease: <em>MTHFR</em> and<em> CTH </em>Gene Polymorphisms, Metabolic Trans-sulfuration and Methylation Pathways, and B Vitamins

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Analysis of telomere length and subtelomeric methylation of circulating leukocytes in women with Alzheimer’s disease

Cited by 26 publications

References 29 publications

Telomere Attrition in Neurodegenerative Disorders

Telomere Attrition in Neurodegenerative Disorders

Single Stem Cell Imaging and Analysis Reveals Telomere Length Differences in Diseased Human and Mouse Skeletal Muscles

Epigenetic Factors in Late-Onset Alzheimer&rsquo;s Disease: <em>MTHFR</em> and<em> CTH </em>Gene Polymorphisms, Metabolic Trans-sulfuration and Methylation Pathways, and B Vitamins

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Epigenetic Factors in Late-Onset Alzheimer’s Disease: <em>MTHFR</em> and<em> CTH </em>Gene Polymorphisms, Metabolic Trans-sulfuration and Methylation Pathways, and B Vitamins