Analysis of Teratogenic Effects of Maternal Treatment with 2‐Bromopropane in Mice

Ishikawa, Hitoshi; Yamauchi, Toru

doi:10.1539/joh.45.63

Cited by 3 publications

(1 citation statement)

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“…administration of 2-bromopropane to the pregnant mice on gestation day 10 did not affect pregnancy or malformations of offspring (Ishikawa and Yamauchi 2003) . On the other hand, exposure to 1-bromopropane ranging from 100 to 996 ppm only during the gestational period did not decrease implantation or litter size (Huntingdon Life Sciences 1999.…”

Section: Developmental Studies On Bromopropanesmentioning

confidence: 81%

Neuro-reproductive toxicities of 1-bromopropane and 2-bromopropane

Ichihara

2004

Int Arch Occup Environ Health

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2-Bromopropane was used as an alternative to chlorofluorocarbons in a Korean electronics factory and caused reproductive and hematopoietic disorders in male and female workers. This causality was revealed by animal studies, and target cells were identified in subsequent studies. After identification of 2-bromopropane toxicity, 1-bromopropane was introduced to the workplace as a new alternative to ozone-depleting solvents. 1-Bromopropane was considered less mutagenic than 2-bromopropane, but, in contrast, animal experiments revealed that 1-bromopropane is a potent neurotoxic compound compared with 2-bromopropane. It was also revealed that 1-bromopropane has reproductive toxicity, but the target cells are different from those of 2-bromopropane. Exposure to 1-bromopropane inhibits spermiation in male rats and disrupts the development of follicles in female rats, in contrast to 2-bromopropane, which targets spermatogonia and oocytes in primordial follicles. After the first animal study describing the neurotoxicity of 1-bromopropane, human cases were reported. Those cases showed decreased sensation of vibration and perception, paresthesia in the lower extremities, decreased sensation in the ventral aspects of the thighs and gluteal regions, stumbling and headache, as well as mucosal irritation, as the initial symptoms. The dose-response of bromopropanes in humans and mechanism(s) underlying the differences in the toxic effects of the two bromopropanes remain to be determined.

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Section: Developmental Studies On Bromopropanesmentioning

confidence: 81%