Analysis of terbinafine in PLGA-based drug delivery systems by a fast and sensitive UHPLC-DAD method

Mrštná, Kristýna; Matoušová, Kateřina; Matouš, Petr; Matysová, Ludmila; Švec, František; Snejdrova, Eva; Krcmova, Lenka Kujovska Kujovska

doi:10.1039/d3ay00506b

Cited by 2 publications

(1 citation statement)

References 13 publications

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“…[4][5][6][7] Various analytical methods for its determination are documented in the literature. Most of these techniques are based on chromatographic methods, [8] including HPLC with UV detection, [9,10] HPLC-MS detection [11,12] and capillary zone electrophoresis. [13] Terbinafine has been determined spectrophotometrically, [14,15] voltammetrically [16] and potentiometrically.…”

Section: Introductionmentioning

confidence: 99%

A Novel Potentiometric Coated Wire Sensor Based on Functionalized Polymeric CaO/ZnO Nanocomposite Synthesized by Lavandula Spica Mediated Extract for Terbinafine Determination

Alterary,

Mostafa,

El‐Tohamy

et al. 2024

ChemistrySelect

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The unique properties of calcium oxide (CaO) and zinc oxide (ZnO) at the nanoscale have attracted the interest of scientists as promising electrically conductive substances for sensing purposes. The content of terbinafine hydrochloride (TRF) in pharmaceutical tablets was determined using a novel coated, wire‐functionalized CaO/ZnO nanocomposite membrane sensor biogenically produced from Lavandula spica extract. Sodium tetraphenylborate was used to prepare the active material (TRF‐TBP). The newly modified sensor gave excellent potentiometric sensitivity with the least squares regression equation EmV=(−58.88X±0.3)+log [TRF]+549.78 and covered a wide linear range (5.0×10−9–1.0×10−2 mol/L) of TRF samples. In contrast, the standard TRF‐TBP sensor wasn't as sensitive when (2.5×10−6–1.0×10−2 mol/L). TRF solutions with regression equation of (−55.728X±0.7)+log [TRF]+396.64. The appropriate pH range was 3–6. The principles of analytical methodology were applied to investigate the validity and suitability of the proposed technique. The proposed sensors were found to be suitable and efficient for the detection of TRF on tablets.

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Section: Introductionmentioning

confidence: 99%

A Novel Potentiometric Coated Wire Sensor Based on Functionalized Polymeric CaO/ZnO Nanocomposite Synthesized by Lavandula Spica Mediated Extract for Terbinafine Determination

Alterary,

Mostafa,

El‐Tohamy

et al. 2024

ChemistrySelect

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The Preparation and Evaluation of a Hydrochloride Hydrogel Patch with an Iontophoresis-Assisted Release of Terbinafine for Transdermal Delivery

Li,

Chen,

et al. 2024

Gels

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Background: Terbinafine hydrochloride (TEB) is a broad-spectrum antifungal medication commonly used to treat fungal infections of the skin. This study designed a hydrogel patch assisted by an iontophoresis system to enhance the transdermal permeability of TEB, enabling deeper penetration into the skin layers. Methods: The influences of current intensity, pH levels, and drug concentration on the TEB hydrogel patch’s permeability were explored using an adaptive ion electroosmosis system. The pharmacokinetic profile, facilitated by iontophoresis for transdermal permeation, was analyzed through the application of microdialysis technology. Scanning electron microscopy and transmission electron microscopy were employed to assess the impact of ion electroosmotic systems on skin integrity. Results: The cumulative drug accumulation within 8 h of the TEB hydrogel patches, assisted by iontophoresis, was 2.9 and 7.9 times higher than without iontophoresis assistance and TEB cream in the control group, respectively. TEB hydrogel patches assisted by iontophoresis can significantly increase the permeability of TEB, and the AUC(0–8 h) was 3.4 and 5.4 times higher, while the Cmax was 4.2 and 7.3 times higher than the TEB hydrogel patches without iontophoresis, respectively. This system has no significant impact on deep-layer cells. Conclusions: This system may offer a safe and effective clinical strategy for the local treatment of deep antifungal infections.

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Analysis of terbinafine in PLGA-based drug delivery systems by a fast and sensitive UHPLC-DAD method

Abstract: The novel ultra-high performance chromatography method with multichannel detection, that allows fast, sensitive, and robust analysis of an antifungal drug terbinafine and its three main impurities β-terbinafine, (Z) terbinafine, and...

Cited by 2 publications

References 13 publications

A Novel Potentiometric Coated Wire Sensor Based on Functionalized Polymeric CaO/ZnO Nanocomposite Synthesized by Lavandula Spica Mediated Extract for Terbinafine Determination

A Novel Potentiometric Coated Wire Sensor Based on Functionalized Polymeric CaO/ZnO Nanocomposite Synthesized by Lavandula Spica Mediated Extract for Terbinafine Determination

The Preparation and Evaluation of a Hydrochloride Hydrogel Patch with an Iontophoresis-Assisted Release of Terbinafine for Transdermal Delivery

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