“…9,[11][12][13][14] Id-FTR prevalence, clinical context, and mechanisms are unknown, underscoring the general need for better FTR mechanism understanding. 1 Previous studies implicated various candidate FTR mechanisms, annular 3,15,16 or valvular, 16,17 but uncertainty persists on processes yielding FTR, particularly when severe. 1 This issue is clinically important because severe TR may portend poor prognosis, 18,19 and its treatment with valve repair is mired by frustrating failures, 17,20 -24 poorly understood.…”