Analysis of the anti-cancer effect of ethyl-p-methoxycinnamate extracted cekur (Kaempferia galanga) on cancer cell lines with wild- type and null p53

Ichwan, Solachuddin Jauhari Arief; Sazeli, Syahirah; Lestari, Widya

doi:10.31436/ijohs.v1i1.16

Cited by 2 publications

(1 citation statement)

References 5 publications

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“…Similarly, our study is in its favor, but we have shown the effects of using rhizome essential oils. There are studies on the antineoplastic activity of EPMC present in Kaempferia , which has proven to have potential in the treatment of oral cancer (Ali et al, 2018; Ichwan et al, 2019; Ichwan et al, 2020). They have examined EPMC, the major constituent of K. galanga , in human lung adenocarcinoma cells.…”

Section: Resultsmentioning

confidence: 99%

Preliminary Screening of in vitro Kaempferia galanga Oil for Anti-Proliferative Activities Against HeLa and MCF-7 Cell

Panigrahi

Parida

2023

Pharmacognosy Magazine

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Background Kaempferia galanga, commonly known as aromatic ginger, is a potential herb with high medicinal value and is used to treat many diseases like diabetes and asthma. Cancer is a group of diseases characterized by abnormal cells that divide uncontrollably and spread throughout the body. Nowadays, medicinal plants are used for their essential oil activities, including anticancerous effects. Objectives The aim of this study is to establish a method for screening in vitro oil cytotoxic effects. Materials and Methods Murashige and Skoog (MS) medium with growth regulators like benzyladenine, kinetin, indole-3-acetic acid, adenine sulfate, and naphthalene acetic acid was used for plantlet production. The in vitro regenerated plants were studied for rhizome oil extraction using Clevenger’s apparatus and gas chromatography-mass spectrometry (GC-MS) analysis, followed by their cytotoxicity study against human cervical cancer cells (HeLa) and human breast cancer cells (MCF7) by (3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide) tetrazolium reduction (MTT) assay. Results Upon analysis, it has been found that this medicinal plant contains ethyl-p-methoxycinnamate (EPMC) (56.41 ± 0.34%) as a vital compound in its rhizome oil. The validation of cytotoxicity in both cell lines was done by treatment with rhizome oil concentrations ranging from 6.25 to 100 µL, respectively. The IC50 value was found to be 44.18 ± 0.65 µL/mL in HeLa and 72.94 ± 0.26 µL/mL in MCF7 cells after 24 h of incubation. Conclusion The results of this study would be helpful for this important medicinal plant to be used by pharmaceuticals in the treatment of cancer.

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Section: Resultsmentioning

confidence: 99%

Preliminary Screening of in vitro Kaempferia galanga Oil for Anti-Proliferative Activities Against HeLa and MCF-7 Cell

Panigrahi

Parida

2023

Pharmacognosy Magazine

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Modulating Effects of Zingiberaceae Phenolic Compounds on Neurotrophic Factors and Their Potential as Neuroprotectants in Brain Disorders and Age-Associated Neurodegenerative Disorders: A Review

et al. 2023

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The Zingiberaceae family possess various phenolic compounds that have significant systemic bioactivities in the brain, including in age-related neurodegenerative diseases. Neurotrophins are growth factors that protect neurons from oxidative stress, and dysregulation of the neurotrophic system may result in neurocognitive disease. Phenolic compounds from the Zingiberaceae family have been used in traditional and complementary medicine (TCM) to improve cognitive functions. These compounds may affect the expression of neurotrophic agents, but their underlying molecular mechanisms require further investigation. Therefore, the goal of this review is to determine the expression and functional roles of phenolic compounds from the Zingiberaceae family in brain disorders and age-related neurodegenerative disorders. While previous studies have proposed various mechanisms for the neuroprotective activity of these compounds, their precise mechanism of action remains complex and poorly understood. Despite some promising findings, there are still shortcomings in the therapeutic use of these herbs, and current interventions involving the Zingiberaceae family appear to be clinically insufficient. This article aims to summarize recent discoveries of phenolic compounds from several Zingiberaceae family members and their use as neuroprotectants and provide the first review of evidence-linked neuroprotective activity of bioactive ingredients from prominent members of the Zingiberaceae family.

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Analysis of the anti-cancer effect of ethyl-p-methoxycinnamate extracted cekur (Kaempferia galanga) on cancer cell lines with wild- type and null p53

Cited by 2 publications

References 5 publications

Preliminary Screening of in vitro Kaempferia galanga Oil for Anti-Proliferative Activities Against HeLa and MCF-7 Cell

Preliminary Screening of in vitro Kaempferia galanga Oil for Anti-Proliferative Activities Against HeLa and MCF-7 Cell

Modulating Effects of Zingiberaceae Phenolic Compounds on Neurotrophic Factors and Their Potential as Neuroprotectants in Brain Disorders and Age-Associated Neurodegenerative Disorders: A Review

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