Analysis of the antimicrobial activity of the essential oil of oregano (Origanum vulgare): a review study on the main effects on pathogens

Araújo, Daniel Lopes; Machado, Bruno Abilio da Silva; Mascarenhas, José Marcos Fernandes; Alves, Suzana Pereira; Sousa, Samilly Lorâna Farias de; Moura, Layanne Cavalcante de; Melo, Beatriz Cardoso; Luz, Thiago Evencio Mendes; Loures, Leandro Luiz da Silva; Apolinário, Joelma Maria dos Santos da Silva; Sousa, Thaysla de Oliveira; Siqueira, Lucas de Carvalho; Moura, Maria Aparecida de Sousa; Rocha, Laísa Ribeiro; Souza, Mariana Silva

doi:10.33448/rsd-v10i2.12584

Cited by 4 publications

(1 citation statement)

References 18 publications

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“…Due to its flavor-adding capacity, Origanum vulgare L. ( Lamiaceae ) is one of the most popular condiments used in food and pet food preparation [ 16 , 17 , 18 , 19 ]. Additionally, it is widely used in the production of essential oils due to its antimicrobial characteristics, which include the presence of carvacrol and thymol, which are effective against different types of fungi [ 20 ]. Moreover, Origanum can be used as a detoxifying substance against aflatoxins, and this point should be investigated [ 21 ].…”

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confidence: 99%

Origanum vulgare Essential Oil Modulates the AFB1-Induced Oxidative Damages, Nephropathy, and Altered Inflammatory Responses in Growing Rabbits

Hassan

Abo-Elmaaty

Zaglool

et al. 2023

Toxins

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The current study was performed to investigate the toxic effects of aflatoxin B1 (AFB1) through the evaluation of kidney function tests and histopathological examination of renal tissues, targeting the therapeutic role of Marjoram (Origanum vulgare essential oil-OEO) in improving health status. Forty-eight New Zealand Whites growing rabbits (four weeks old) weighing on average 660.5 ± 2.33 g were randomly and equally distributed into four groups, each of which had four replicas of three animals as the following: Control group (only basal diet), AFB1 group (0.3 mg AFB1/kg diet), OEO group (1 g OEO/kg diet) and co-exposed group (1 g OEO/kg + 0.3 mg AF/kg diet). Our study lasted eight weeks and was completed at 12 weeks of age. The results revealed that OEO decreased the toxic effects of AFB1 in rabbit kidneys by substantially reducing the cystatin C levels in the AFB1 group. Additionally, OEO decreased oxidative stress and lipid peroxidation levels in the co-exposed group. Moreover, OEO reduced DNA damage and inflammatory response in addition to the down-regulation of stress and inflammatory cytokines-encoding genes. Besides, OEO preserved the cytoarchitecture of rabbits’ kidneys treated with AFB1. In conclusion, O. vulgare essential oil supplementation ameliorated the deleterious effects of AFB1 on the rabbits’ kidneys by raising antioxidant levels, decreasing inflammation, and reversing oxidative DNA damage.

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Section: Introductionmentioning

confidence: 99%

Origanum vulgare Essential Oil Modulates the AFB1-Induced Oxidative Damages, Nephropathy, and Altered Inflammatory Responses in Growing Rabbits

Hassan

Abo-Elmaaty

Zaglool

et al. 2023

Toxins

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Cymbopogon citratus Essential Oil in Controlling of Bacteria Associated with Oral Cavity of Dogs In Vitro and Dry Pet Feed

Cunha Del Vechio,

Bezerra,

Estevam dos Santos

et al. 2024

Foodborne Pathogens and Disease

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Antiviral and virucidal potential of Origanum vulgare Linn. (oregano) extracts against Bovine alphaherpesvirus 1 (BoHV-1)

Picoli

Waller

Hoffmann

et al. 2021

RSD

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The search for natural resources with antiviral potential, as an alternative to synthetic drugs, has been growing and, in this sense, oregano presents itself as a potential candidate. However, the antiviral studies with oregano are still poorly explored. BoHV-1 stands out among veterinary pathogens, for its economic impact on cattle production. In this study, the antiviral and virucidal activity of polar extracts of Origanum vulgare was evaluated against BoHV-1. Infusion (INF10), decoction (DEC), and hydroalcoholic (HAE) extracts were tested to cytotoxic and antiviral assays on MDBK cells. Cytotoxic effects were analyzed through MTT assay and the antiviral activity was expressed as a percentage of inhibition (PI). BoHV-1 was incubated with O. vulgare extracts as virucidal assay. Concentrations ≤3.12 mg/ml (INF10) and ≤1.56 mg/ml (DEC/HAE) preserved the cell viability above 60%, and all extracts were safe (>96%) between 0.78 and 0.39 mg/ml. Regarding the antiviral activity, pre-treatment of all extracts highlighted in comparison to the post-treatment. The pre-treatment of infusion at 2 mg/ml highlighted due to the high cell viability (84.69%) and the elimination of the viral load. All extracts inactivated BoHV-1 from 2 hours of incubation (20 mg/ml), showing virucidal activity. These findings may be related to 4-hydroxybenzoic acid as prevalent in all extracts. These findings showed the in vitro antiviral and virucidal activity of oregano polar extracts against BoHV-1 and may be promising for the therapeutic use against herpesviruses infections.

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Analysis of the antimicrobial activity of the essential oil of oregano (Origanum vulgare): a review study on the main effects on pathogens

Cited by 4 publications

References 18 publications

Origanum vulgare Essential Oil Modulates the AFB1-Induced Oxidative Damages, Nephropathy, and Altered Inflammatory Responses in Growing Rabbits

Origanum vulgare Essential Oil Modulates the AFB1-Induced Oxidative Damages, Nephropathy, and Altered Inflammatory Responses in Growing Rabbits

Cymbopogon citratus Essential Oil in Controlling of Bacteria Associated with Oral Cavity of Dogs In Vitro and Dry Pet Feed

Antiviral and virucidal potential of Origanum vulgare Linn. (oregano) extracts against Bovine alphaherpesvirus 1 (BoHV-1)

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