An extensive network of tunnels has recently been constructed in the Qinling Mountains. Characterized by high and steep terrain, this network has led to frequent traffic accidents. To address this issue, this paper introduces the theory of resilience into the evaluation system of safety systems during the operation period of highway tunnel groups. Based on this, this paper establishes a resilience evaluation index system for the operation safety system of highway tunnel groups, including a human system, vehicle system, and road system. To address both qualitative and quantitative issues concerning the indicators, this paper employs the analytic hierarchy process (AHP) and entropy weight method to combine and assign weights to the resilience evaluation indicators. Subsequently, the cloud model method is utilized to quantify the level of resilience of the highway tunnel group safety system during the operation period. The study results unveiled the patterns of traffic accidents within the Qinling Tunnel Group from the perspectives of vehicle, road, and human factors. The final weight allocation reveals that the road system has the highest proportion, exerting the greatest influence as a primary level index. Moreover, by taking the Qinling Tunnel Group on the Xihan Expressway as an engineering example, the resilience level of the case project was analyzed and obtained. Proposals for enhancing resilience were put forth, taking into account the project’s unique attributes, encompassing adaptability, resistance, and recovery. Overall, this study validates the feasibility and reliability of the proposed method for assessing the resilience of highway networks, offering empirical support for transportation administrators in the implementation of resilience-enhancing strategies.