Analysis of the CC chemokine receptor 5 m303 mutation in infants born to HIV-1-seropositive mothers

Ometto, Lucia; Bertorelle, Roberta; Mainardi, Michele; Giurisato, Maristella; Chieco‐Bianchi, Luigi; Rossi, Anita De

doi:10.1097/00002030-199905070-00026

Cited by 13 publications

(3 citation statements)

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“…The allele of CCR5m303 was not detected in subjects of any ethnic group in the Chinese mainland ( fig. 1B), which is in contrast to the allelic frequency of 0.002 reported in Italian population [14] . Fig.…”

Section: Resultscontrasting

confidence: 68%

“…The Chinese mainland hosts 1/4 of the world population and the incidence of HIV-1 infection and AIDS is rapidly increasing in recent years [12] . However, limited information is available about the genetic polymorphisms that affect susceptibility of various ethnic groups in this area to HIV-1 infection and disease progression [13,14] . This prompted us to examine the genetic frequency and polymorphism of chemokine and chemokine receptor alleles in the Chinese mainland to favour the design of preventive and therapeutic strategies against HIV-1 infection.…”

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confidence: 99%

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Polymorphisms of chemokine receptors and its ligand alleles influencing genetic susceptibity to HIV-1 infection in eight ethnic groups in Chinese mainland

et al. 2001

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Limited genetic information is available concerning the polymorphisms of HIV-1 resistant genes in indigenous Chinese populations. The aim of this study is to identify the allelic frequencies of the chemokine and chemokine receptor genes in the Chinese mainland. Genomic DNA samples extracted from whole blood of 2318 subjects were analyzed by using PCR or PCR/restriction fragment length polymorphism (RFLP) assays, and further confirmed by direct DNA sequencing. Higher frequencies of mutant CCR2-64I (19.15% 28.79%) and SDF1-3'A (19.10% 29.86%) alleles were found in subjects of 8 ethnic groups in the Chinese mainland. In contrast, the 32 mutation in CCR5 gene occurs at a very low frequency (0.0016, n=1287) in Han population. A relatively high frequency of CCR5-wt/ 32 heterozygotes was observed in Uygurian and Mongolian populations. No 32 mutation allele was detected in Tibetan and other 4 ethnic groups in Yunnan Province. There was no CCR5-m303 mutation in subjects of any ethnic group in the Chinese mainland. Our results suggest that the CCR5-32 mutation is not a major resistant factor against HIV-1 infection and disease progression in Han, Tibetan and other ethnic groups in Yunnan Province. Whether higher frequencies of CCR2-64I and SDF1-3 A alleles constitute major genetic resistant factors or not remains to be clarified.

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Section: Resultscontrasting

confidence: 68%

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Polymorphisms of chemokine receptors and its ligand alleles influencing genetic susceptibity to HIV-1 infection in eight ethnic groups in Chinese mainland

et al. 2001

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“…The m303 mutation has only been detected in heterozygosis in 2.86% (1/35) of African-American and 5.56% (1/18) of French (who also possessed the ∆32 allele in compound trans-heterozygosis) individuals at high risk for HIV-1 infection (Carrington et al 1997;Quillent et al 1998), indeed, Quillent et al (1998 found as few as 1.4% of blood donors of undefined ethnic origin possessed the m303 mutation Ometto et al (1999) observed an m303 allelic frequency of 0.002 for uninfected Italian infants born to HIV-1 seropositive mothers and 0 for HIV-infected Italian children. The mutant m303 allele was not identified in 200 Kuwaitis (Voevodin et al 1999), nor among 687 South Africans (Williamson et al 2000) or in seronegative but HIV-1 infected Chinese (Shieh et al1999;Wang et al 2003), although the m303 gene was detected at an allelic frequency of 0.007 in 145 Caucasians (Williamson et al 2000).…”

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[No Title Available]

Grimaldi¹,

Acosta

Cabral-Oliveira

et al. 2005

Genet. Mol. Biol.

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The main coreceptor gene involved in HIV-1 infection is CCR5 β chemokine receptor gene for which several mutations have been described, some of which have correlated with HIV-1 infection, acquired immune deficiency syndrome (AIDS), or both. Deletion of 32bp in the CCR5 gene (∆32) has been shown to confer resistance to infection by HIV-1 R5 strains. Another mutation, characterized by a thymine to adenine (T to A) nucleotide substitution at position 303 (m303), has shown the same effects as the ∆32 mutation, with previous studies having shown that the allele frequency of the CCR5-m303 mutation is 0.014 in African-American and 0.007 in French populations. The Brazilian population is known to be genetically diverse, because of which we investigated the allele frequency of the CCR5-m303 mutation in three different Brazilian ethnic groups containing individuals who were not infected with HIV-1 and also in a cohort of HIV-1 long-term non-progressors. We used the polymerase chain reaction (PCR) and HincII restriction fragment length polymorphisms (RFLP) to investigate these populations and found that none of the 566 individuals examined the mutant CCR5-m303 allele. These results are in accordance with the previously reported allelic frequencies for African-American and Caucasian populations and may reflect the real prevalence of the m303 mutation in Brazil.

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Maternal and Perinatal Infection in Pregnancy

Bernstein¹

2017

Obstetrics: Normal and Problem Pregnancies

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Analysis of the CC chemokine receptor 5 m303 mutation in infants born to HIV-1-seropositive mothers

Cited by 13 publications

References 9 publications

Polymorphisms of chemokine receptors and its ligand alleles influencing genetic susceptibity to HIV-1 infection in eight ethnic groups in Chinese mainland

Polymorphisms of chemokine receptors and its ligand alleles influencing genetic susceptibity to HIV-1 infection in eight ethnic groups in Chinese mainland

[No Title Available]

Maternal and Perinatal Infection in Pregnancy

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