2022
DOI: 10.1159/000523824
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Analysis of the Clinical Characteristics of Hyponatremia Induced by Trimethoprim/Sulfamethoxazole

Abstract: <b><i>Background:</i></b> Trimethoprim-sulfamethoxazole (TMP/SMX) causes hyperkalemia, and hyponatremia caused by TMP/SMX is a challenge for clinicians. We described the clinical features of hyponatremia induced by TMP/SMX after collecting cases. <b><i>Summary:</i></b> The median age of the 24 patients (10 males and 14 females) was 67 years (range: 28–90 years). Hyponatremia induced by TMP/SMX manifested as nausea (41.7%) and vomiting (29.2%) or asymptomatic hypo… Show more

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“…TMP works by blocking amiloride-sensitive sodium channels in the distal convoluted tubules and collecting ducts. 1 Usually, hyponatremia begins between days 3 and 10 1 and resolves within 3 weeks after stopping the drug. Similarly to amiloride, TMP can cause hyperkalemia and hyponatremia.…”
Section: Introductionmentioning
confidence: 99%
See 1 more Smart Citation
“…TMP works by blocking amiloride-sensitive sodium channels in the distal convoluted tubules and collecting ducts. 1 Usually, hyponatremia begins between days 3 and 10 1 and resolves within 3 weeks after stopping the drug. Similarly to amiloride, TMP can cause hyperkalemia and hyponatremia.…”
Section: Introductionmentioning
confidence: 99%
“…Similarly to amiloride, TMP can cause hyperkalemia and hyponatremia. 1,2 Hyponatremia occurs in approximately 72% of patients receiving high doses of intravenous (IV) TMP-SMX. 3 Hyponatremia can, however, be caused by low prophylactic doses.…”
Section: Introductionmentioning
confidence: 99%