Analysis of the Clinical Relevance of Histological Classification of Benign Epithelial Salivary Gland Tumours

Hellquist, Henrik B.; Paiva-Correia, A.; Poorten, Vincent Vander; Quer, Miquel; Hernández-Prera, Juan C.; Andreasen, Simon; Zbären, Peter; Skálová, Alena; Rinaldo, Alessandra; Ferlito, Alfio

doi:10.1007/s12325-019-01007-3

Cited by 65 publications

(57 citation statements)

References 125 publications

(138 reference statements)

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“…These WT variants can lead to diagnostic difficulties. Thus, squamous metaplasia (Figure ) in some cases of WT with considerable cytological atypia mimics squamous cell carcinoma or mucoepidermoid carcinoma …”

Section: Wt Cytopathologymentioning

confidence: 99%

“…Nondiagnostic aspirates contain non‐specific cyst fluid, with or without lymphoid cells and without oncocytes. In cases of nondiagnostic aspirates and in unclear cases with prominent epithelial and lymphoid cells atypia, repeat aspiration should be performed …”

Section: Wt Cytopathologymentioning

confidence: 99%

“…Oncocytic cells are found in oncocytosis or oncocytic hyperplasia, oncocytoma, oncocytic carcinoma, WT, pleomorphic adenoma, ACC and rarely in MEC and other salivary gland tumours: myoepithelioma; basal cell adenoma; cystadenoma; canalicular adenoma; and polymorphous low‐grade adenocarcinoma (Table ) . Thus, papillary oncocytic cystadenoma resembles WT, but this tumour usually involves minor salivary glands and lacks an abundant lymphoid component …”

Section: Differential Cytopathological and Histopathological Diagnosimentioning

confidence: 99%

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Cytopathology and diagnostics of Warthin's tumour

Sučić

Ljubić²,

Perković³

et al. 2020

Cytopathology

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Warthin's tumour (WT) is a benign epithelial salivary tumour, one type of salivary adenoma. Histologically, WT is structured of two components, epithelial tissue that often lines cystic formations and lymphoid tissue in the tumour stroma. FNA is a reliable diagnostic approach in the diagnosis of salivary gland lesions allowing a highly accurate categorization of benign tumour‐like lesions, benign tumours and malignant tumours. In the proposed Milan reporting system of salivary gland lesions, WT is categorized in the IVA group of benign neoplasms. Accurate cytological diagnosis is straightforward when three characteristic components are present: oncocytes, either isolated or associated in clusters, lymphocytes and lymphoid cells and often an inflammatory/necrotic‐like substance. Also, specific features of scintigraphy and radiological imaging contribute to the diagnosis of WT. WT is categorized according to Seifert G. et al in 4 types, depending on the proportions of the epithelial component and lymphoid stroma. Differential cytopathological and pathohistological diagnosis include other salivary gland lesions with lymphoid, oncocytic epithelial and cystic components. In some cases, such as the metaplastic WT variant, there are additional cytopathological and histological diagnostic difficulties. Moreover, bilateral, multicentric or multiple and infrequently seen extra‐salivary localizations of WT are associated with further cytopathological diagnostic difficulties. Also, a rare possibility of malignant transformation of the epithelial or lymphoid component of WT as well as possible association with other primary tumours remains a challenge in accurate cytopathological and histological diagnosis of WT.

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Section: Wt Cytopathologymentioning

confidence: 99%

Section: Wt Cytopathologymentioning

confidence: 99%

Section: Differential Cytopathological and Histopathological Diagnosimentioning

confidence: 99%

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Cytopathology and diagnostics of Warthin's tumour

Sučić

Ljubić²,

Perković³

et al. 2020

Cytopathology

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“…This patient was initially diagnosed with carcinoma arising from a sebaceous lymphadenoma. Sebaceous lymphadenomas are rare and benign salivary gland tumors that consist of benign epithelial cells with sebaceous differentiation and a dense lymphoid component [26, 27]. Sebaceous lymphadenomas can present for long durations as painless masses in the parotid gland and can be cured by complete surgical excision [26, 27].…”

Section: Discussionmentioning

confidence: 99%

“…Sebaceous lymphadenomas are rare and benign salivary gland tumors that consist of benign epithelial cells with sebaceous differentiation and a dense lymphoid component [26, 27]. Sebaceous lymphadenomas can present for long durations as painless masses in the parotid gland and can be cured by complete surgical excision [26, 27]. Although sebaceous lymphadenomas are benign tumors, malignancies that have arisen in sebaceous lymphadenomas have been reported, and lymphadenomas can be misdiagnosed as metastatic carcinomas in the parotid lymph node or even as lymphoepithelial carcinomas in the parotid gland [27].…”

Section: Discussionmentioning

confidence: 99%

Myeloid Sarcoma That Infiltrated a Preexisting Sebaceous Lymphadenoma in the Parotid Gland: Diagnostic Challenges and Literature Review

Shim

Kim

et al. 2019

BioMed Research International

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Myeloid sarcoma (MS) is a rarely encountered extramedullary localized tumor that is composed of immature myeloid cells. We reported an extremely rare case of MS with concurrent bone marrow (BM) involvement that invaded into a preexisting sebaceous lymphadenoma in the parotid gland and neck lymph nodes. Prompted by this case, we also present a literature review of MS invasion into salivary glands. A 62-year-old man was initially diagnosed with carcinoma that arose in a sebaceous lymphadenoma in the parotid gland, through a total parotidectomy with neck dissection. After an extensive histopathological review that included immunohistochemistry, a pathologic diagnosis of MS with infiltration into the sebaceous lymphadenoma with concurrent BM involvement was confirmed. MS is difficult to diagnose accurately; herein, we analyzed the clinical presentations and effectiveness of the various diagnostic methods with a review of the literature. There are 17 cases, including our case, reported in 13 studies. Of the cases in which the salivary glands were affected, 10 involved the parotid gland, six involved the submandibular gland, and one involved both. Isolated invasion of the salivary gland was found in one case of parotid gland invasion and three cases of submandibular gland invasion. In 13 cases, the salivary glands were affected by various other lesions. Although there were no incidences of isolated MS, six patients were diagnosed with secondary MS and eight patients with MS with BM involvement, including this case. The diagnosis of MS is difficult given its rarity, and a high index of suspicion and integrated radiologic and careful histopathologic evaluation are required. Most cases of MS infiltrating the salivary gland might be indicated by the possibility of BM involvement. MS with BM involvement predicts poor prognosis and the need for intensive systemic treatment.

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The Molecular Biology of Benign and Malignant Salivary Gland Tumors

Todd¹

2021

Salivary Gland Pathology

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Analysis of the Clinical Relevance of Histological Classification of Benign Epithelial Salivary Gland Tumours

Cited by 65 publications

References 125 publications

Cytopathology and diagnostics of Warthin's tumour

Cytopathology and diagnostics of Warthin's tumour

Myeloid Sarcoma That Infiltrated a Preexisting Sebaceous Lymphadenoma in the Parotid Gland: Diagnostic Challenges and Literature Review

The Molecular Biology of Benign and Malignant Salivary Gland Tumors

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