Analysis of the clinicopathological features and prognostic factors in 734 cases of Chinese Hui and Han patients with adenocarcinoma of the esophagogastric junction

Cao, Jianqiao; Yang, Ting; Wang, Guanhua; Zhang, Hongfei; You, Yanjie; Chen, Jing; Yang, Jingwen; Yang, Wenjun

doi:10.1016/j.suronc.2018.07.008

Cited by 12 publications

(10 citation statements)

References 27 publications

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“…Several other researchers showed that distal GC had a higher family history rate than proximal GC, which suggests a genetic predisposition in patients in the distal GC group [24]. We also found that the mortality rate of proximal GC in both male and female patients was higher than that in distal GC, which is consistent with some other previous reports [25,26].…”

Section: Discussionsupporting

confidence: 92%

“…Because there are no characteristic clinical manifestations in the early stage, GC patients are often in advanced stages at the time of initial diagnosis [4,5,27]. Invasive tumors may be closer to tissue blood vessels, nerves, lymphoid vessels, and surrounding organs, so their invasive range is wide, destructive to the body leading to more fatal complications, and are more likely to have distant metastasis [26]. Accordingly, the OS is signi cantly worse in patients with deeper invasion.…”

Section: Discussionmentioning

confidence: 99%

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The effects of sex disparities on clinicopathological characteristics and prognosis of 3937 Chinese patients with gastric cancer

Zhang¹,

Chen²,

Chen³

et al. 2020

Preprint

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Objective: To investigate the effects of sex disparities on clinicopathological characteristics and prognosis of 3937 Chinese gastric cancer (GC) patients.Materials and methods: A total of 3937 Chinese patients, including 3098 males (78.7%) and 839 females (21.3%), diagnosed with GC at the General Hospital of Ningxia Medical University of China were selected through inclusion and exclusion criteria, and the prognosis of the patients was followed up. Clinicopathological features were assessed, and univariate and multivariate survival analyses were performed.Results: The ratio of male to female was approximately 3.7:1. Compared to females, male patients were relatively older and had more cigarette smoking and alcohol consumption history, higher percentage of late-stage GC, more proximal tumors, and better differentiation of cancer (p<0.05). There was no significant difference between the male and female patient groups in terms of the cumulative overall survival rate (62.1% vs. 64.8%), 1-year survival rate (69.7% vs. 71.6%), 3-year survival rate (46.6% vs. 48.5%)and 5-year survival rate (20.8% vs. 15.8%). Female patients with cigarette smoking history and male patients in stage IV or without treatment had a poorer prognosis (p<0.05). Age, clinical differentiation, pathologic T stage, pathologic N stage, clinical stage, and surgery type were significantly independent prognostic factors (p<0.05).Conclusion: Sex disparities play an important role in clinicopathological features and prognosis of GC. Considering that the effect of sexual dimorphism in the development and prognosis of GC is complex, further research is warranted.

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Section: Discussionsupporting

confidence: 92%

Section: Discussionmentioning

confidence: 99%

The effects of sex disparities on clinicopathological characteristics and prognosis of 3937 Chinese patients with gastric cancer

Zhang¹,

Chen²,

Chen³

et al. 2020

Preprint

Self Cite

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“…However, perioperative chemotherapy can improve the long-term prognosis of AEG patients to some extent. The current result was consistent with previous studies [42]. The EORTC40954 clinical trial indicated that the preoperative chemotherapy combined with surgery could increase R0 resection but failed to show survival benefit in stage III and IV (cM0) of AEG or gastric cancer patients [43].…”

Section: Discussionsupporting

confidence: 90%

Assessment of risk factors of lymph node metastasis and prognosis of Siewert II/III adenocarcinoma of esophagogastric junction: a retrospective study

Zheng¹,

Zhang²,

Xu³

et al. 2020

Preprint

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Background Adenocarcinoma of esophagogastric junction (AEG) has a high incidence, while the extent of lymph node dissection (LND) and prognosis are still controversial. The present study aimed to explore the risk factors of lymph node metastasis (LNM) and prognosis in Siewert II/III AEG patients. Methods A total of 134 patients who underwent surgical operation between July 2013 and December 2019 at the Beijing Friendship Hospital were retrospectively reviewed. The patients were followed up until January 2020. The data were analyzed using logistic regression. Survival analyses were performed using Cox regression. Results Multivariate analysis revealed that the parameters infiltration depth (OR=4.341, 95%CI: 2.498-7.545, P=0.000), gross type (OR=3.626, 95% CI: 1.425-9.228, P=0.007) and intravascular cancer embolus (OR=2.888, 95%CI: 1.106-7.544, P=0.030) correlated with LNM. For all patients, the lymph nodes No. 1, 2, 3, 4, 7, 11 indicated higher lymph node metastatic rate in the abdominal cavity. However, No.5 and No. 6 indicated different tendency, which was higher in Siewert III AEG and lower in Siewert II AEG patients. Mediastinal LNM of Siewert II AEG mainly occurred in No. 110 and No. 111 cases corresponding to 7.1 and 3%, respectively, compared with those noted in Siewert III AEG patients. The 3-year overall survival analysis revealed that LNM ( P= 0.046) and chemotherapy ( P= 0.007) exhibited significant differences. Conclusion The infiltration depth, gross type and intravascular cancer embolus were independent risk factors of LNM. For Siewert II AEG patients, it is reasonable to remove both celiac and mediastinal lymph nodes. This was noted notably for No.1, 2, 3, 4, 7, 11, 110 and No.111. For No.5 and No.6 lymph nodes dissection was not required. For Siewert III AEG patients, mediastinal LND was not required. However, it was necessary to perform pyloric lymphadenectomy, which was performed for No.5 and No.6 lymph nodes. In addition, patients with LNM exhibited worse long-term prognosis. The data indicated that perioperative chemotherapy could improve the prognosis of AEG patients.

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“…More recently, a study by Cao and colleagues indicated that the survival between the patients with NDLN < 15 and NDLN ≥ 15 had no signi cant difference [35]. This perspective was supported by several retrospective studies, which proposed that the NDLN had no impact on overall survival, while a lower LNR was connected to favorable survival [9,24].…”

Section: Discussionmentioning

confidence: 94%

Lymph Node Ratio Is an Independent Prognostic Factor for Patients with Siewert Type II Adenocarcinoma of Esophagogastric Junction: Results from a 10-Year Follow-up Study

Zhang

Liu

Zeng

2020

J Gastrointest Canc

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Background Emerging evidences suggest that lymph node ratio (LNR), the number of metastatic lymph node (LN) to the total number of dissected lymph nodes (NDLN), may predict survival in multiple types of solid tumor. However, the prognostic role of LNR in adenocarcinoma of the esophagogastric junction (AEG) remains uninvestigated. The study is intended to determine the prognostic value of LNR in the patients with Siewert type II AEG. Methods A total of 342 patients with Siewert type II AEG who underwent R0 resection were enrolled in this study. The optimal cutoff of LNR was strati ed into tertiles using X-tile software. The log-rank test was used to evaluate the survival differences, and multivariate Cox regression analysis were performed to determine the independent prognostic variables. Results The optimal cutoff of LNR were classi ed as LNR = 0, LNR between 0.01 and 0.40 and LNR > 0.41. Patients with high LNR had a shorter 5-and 10-year disease-speci c survival (DSS) rate (8.5%, 1.4%) compared with those with moderate LNR (20.4%, 4.9%) and low LNR (58.0%, 27.5%) (P < 0.001). Multivariate Cox regression analysis indicated that LNR was an independent factor for DSS after adjusting for confounding variables (P < 0.05). Furthermore, after strati cation by NDLN between NDLN < 15 group and NDLN ≥ 15 group, the LNR remained a signi cant predictor for DSS (P < 0.05). Conclusions LNR is an independent predictor for DSS in patients with Siewert type II AEG regardless of NDLN. Patients with higher LNR have signi cantly shorter DSS.

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Analysis of the clinicopathological features and prognostic factors in 734 cases of Chinese Hui and Han patients with adenocarcinoma of the esophagogastric junction

Cited by 12 publications

References 27 publications

The effects of sex disparities on clinicopathological characteristics and prognosis of 3937 Chinese patients with gastric cancer

The effects of sex disparities on clinicopathological characteristics and prognosis of 3937 Chinese patients with gastric cancer

Assessment of risk factors of lymph node metastasis and prognosis of Siewert II/III adenocarcinoma of esophagogastric junction: a retrospective study

Lymph Node Ratio Is an Independent Prognostic Factor for Patients with Siewert Type II Adenocarcinoma of Esophagogastric Junction: Results from a 10-Year Follow-up Study

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