Analysis of the CYP3A4*1B Gene Variant in an Iranian Population: Pilot Base Study

Abstract

ABSTRACT. Various studies revealed that, CYP3A4*1B, as a variant allele of CYP3A4 gene, has variations in populations with different ethnic background. In this pilot research work, we studied 183 healthy non consanguinity men of an Iranian origin for this genetic variation. We applied RFLP-PCR technique for this research study. In contrast with other researches, in Asian country (such as China and Japan with 0% allele frequency) our study showed that frequency of this allele in Iranian men among an Asian continent is 3%. This finding is an important attempt in pharmacogenetics research endeavor.