Analysis of the distribution of HLA-A alleles in populations from five continents

Middleton, Derek; Williams, Fionnuala; Meenagh, Ashley; As, Daar; Gorodezky, Clara; Hammond, M. G.; Nascimento, Evaldo; Briceño, Ignacio; Pérez, Montse

doi:10.1016/s0198-8859(00)00178-6

Cited by 88 publications

(100 citation statements)

References 14 publications

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“…Los alelos más frecuentes fueron el A*02 (22,5 %) y el A*24 (20,2 %), lo cual coincide con los datos reportados en otros estudios en Colombia, en Latinoamérica y en la población hispana en general, los cuales evidencian que estos dos alelos aparecen con una frecuencia superior al 40 % (11)(12)(13)(14)(15)(16)(17)(18)(19)(20)(21)(22)(23)(24)(25).…”

Section: Discussionunclassified

Determination of HLA -A, -B, -DRB1 polymorphism in brain dead organ donors representative of the Colombian general population, 2007-2014

et al. 2017

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Introducción. Los genes que codifican para el sistema de antígenos leucocitarios humanos (HLA) son altamente polimórficos y tiene alta importancia en procedimientos de trasplante de órganos. La determinación de frecuencias alélicas en poblaciones definidas se tiene en cuenta en la designación de criterios científicos para la asignación de órganos.Objetivo. Establecer las frecuencias antigénicas y haplotípicas de HLA -A, -B, y -DRB1 en donantes de órganos en muerte encefálica, representativos de población colombiana.Materiales y métodos. Estudio descriptivo retrospectivo que incluyó 2.506 donantes cadavéricos de órganos en el que se realizó un análisis alélico y haplotípico de HLA- A, HLA-B, HLA-DRB1, así como la determinación del desequilibrio de Hardy Weinberg.Resultados. Se identificaron 21, 43 y 15 grupos alélicos para los locus A*, B* y DRB1*, respectivamente. Fue posible la identificación de 1.268 haplotipos HLA A-HLA B-HLA DR; 409 haplotipos HLA A, B; 383 haplotipos HLA B, DR y 218 haplotipos HLA A, DR. Los tres locus se encontraron en equilibrio de Hardy-Weinberg al encontrar valores de p<0,05 entre el número de heterocigóticos observados en relación al número de heterocigóticos esperados.Conclusiones. Este estudio por primera vez proporciona información sobre la distribución de los alelos HLA clase I y II en población de donantes de órganos, con representación de individuos de las seis regionales en las que está dividida estructuralmente Colombia para la prestación de servicios de trasplante.

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Section: Discussionunclassified

Determination of HLA -A, -B, -DRB1 polymorphism in brain dead organ donors representative of the Colombian general population, 2007-2014

et al. 2017

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“…[11] The etiologies of markedly increased incidence rates of end-stage renal failure among African-, Native-, Hispanic-, and Asian Americans, relative to European Americans, are controversial. [12] HLA frequencies of the control group were in concordance with the distribution of HLA allele frequencies in the Turkish population.…”

Section: Discussionmentioning

confidence: 99%

Impact of HLA on the Underlying Primary Diseases in Turkish Patients with End-Stage Renal Disease

et al. 2009

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The number of patients with end stage renal disease (ESRD) is increasing faster than the number of renal transplantations performed per year worldwide. Of the primary diseases leading to ESRD, diabetic nephropathy is the leading cause. The purpose of the present study is to investigate the association of HLA with the primary diseases leading to ESRD in Turkish patients. A total of 3230 individuals comprising 587 ESRD patients and 2643 healthy controls were enrolled into the study. Class I HLA-A, -B typing was performed by CDC method, while class II HLA-DRB1 typing was performed by low resolution PCR-SSP. We found a significant negative association between almost all A locus antigens and primary disease groups classified as chronic glomerulonephritis and hypertensive nephrosclerosis (p < 0.05).HLA-B58 and HLA-DRB1*03 significantly correlated with amyloidosis and diabetic nephropathy, respectively. Determination of HLAs as risk factors for primary diseases leading to ESRD might be beneficial in preventing progression to ESRD and recurrence of the primary disease post-transplantation.

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“…For example, there was a cumulative HLA-A*, B*, and Cw* allele frequency of 0.919 in single alleles that were found to restrict the identified optimal CTL epitopes (Table II) compared with 0.572 for the same HLA alleles found in Caucasians (34). By comparison, there was a cumulative HLA allele frequency of 1.022 in a healthy Zulu population (35,36), inferring that there was minimal skewing of HLA due to HIV-1 infection in our cohort.…”

Section: Multiple and Unique Hla Restrictions Of Ctl Epitopesmentioning

confidence: 94%

Novel and Promiscuous CTL Epitopes in Conserved Regions of Gag Targeted by Individuals with Early Subtype C HIV Type 1 Infection from Southern Africa

Masemola

Mashishi

Khoury

et al. 2004

The Journal of Immunology

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Characterization of optimal CTL epitopes in Gag can provide crucial information for evaluation of candidate vaccines in populations at the epicenter of the HIV-1 epidemic. We screened 38 individuals with recent subtype C HIV-1 infection using overlapping consensus C Gag peptides and hypothesized that unique HLA-restricting alleles in the southern African population would determine novel epitope identity. Seventy-four percent of individuals recognized at least one Gag peptide pool. Ten epitopic regions were identified across p17, p24, and p2p7p1p6, and greater than two-thirds of targeted regions were directed at: TGTEELRSLYNTVATLY (p17, 35%); GPKEPFRDYVDRFFKTLRAEQATQDV (p24, 19%); and RGGKLDKWEKIRLRPGGKKHYMLKHL (p17, 15%). After alignment of these epitopic regions with consensus M and a consensus subtype C sequence from the cohort, it was evident that the regions targeted were highly conserved. Fine epitope mapping revealed that five of nine identified optimal Gag epitopes were novel: HLVWASREL, LVWASRELERF, LYNTVATLY, PFRDYVDRFF, and TLRAEQATQD, and were restricted by unique HLA-Cw*08, HLA-A*30/B*57, HLA-A*29/B*44, and HLA-Cw*03 alleles, respectively. Notably, three of the mapped epitopes were restricted by more than one HLA allele. Although these epitopes were novel and restricted by unique HLA, they overlapped or were embedded within previously described CTL epitopes from subtype B HIV-1 infection. These data emphasize the promiscuous nature of epitope binding and support our hypothesis that HLA diversity between populations can shape fine epitope identity, but may not represent a constraint for universal recognition of Gag in highly conserved domains.

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Analysis of the distribution of HLA-A alleles in populations from five continents

Cited by 88 publications

References 14 publications

Determination of HLA -A, -B, -DRB1 polymorphism in brain dead organ donors representative of the Colombian general population, 2007-2014

Determination of HLA -A, -B, -DRB1 polymorphism in brain dead organ donors representative of the Colombian general population, 2007-2014

Impact of HLA on the Underlying Primary Diseases in Turkish Patients with End-Stage Renal Disease

Novel and Promiscuous CTL Epitopes in Conserved Regions of Gag Targeted by Individuals with Early Subtype C HIV Type 1 Infection from Southern Africa

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